Hydralazine Hydrochloride

Hypertension, Congestive Heart Failure, Hypertension + 1 more

Treatment

2 FDA approvals

20 Active Studies for Hydralazine Hydrochloride

Treatment for

Hypertension

What is Hydralazine Hydrochloride

HydralazineThe Generic name of this drug

Treatment SummaryHydralazine is a medication used to treat high blood pressure and heart failure. It was originally developed in the 1950s to treat malaria and was later discovered to also reduce blood pressure. Hydralazine is not the first line of treatment for these conditions anymore, as newer medications have been developed, but it is still used as an adjunct therapy. Hydralazine hydrochloride was approved by the FDA in 1953.

Apresoline hydrochlorideis the brand name

image of different drug pills on a surface

Hydralazine Hydrochloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Apresoline hydrochloride

Hydralazine

1953

300

Approved as Treatment by the FDA

Hydralazine, also called Apresoline hydrochloride, is approved by the FDA for 2 uses which include Hypertensive disease and Hypertension, Essential Hypertension .

Hypertensive disease

Helps manage Hypertension, Essential Hypertension

Hypertension, Essential Hypertension

Helps manage Hypertension, Essential Hypertension

Effectiveness

How Hydralazine Hydrochloride Affects PatientsHydralazine helps to lower blood pressure by relaxing the small muscles in the arteries. It's effects start two to six hours after taking it and can last up to 300mg. People taking this drug should be aware of the possibility of developing a condition called systemic lupus erythematosus.

How Hydralazine Hydrochloride works in the bodyHydralazine relaxes the muscles of the blood vessels, reducing their resistance and allowing more blood to flow. This in turn increases the heart rate and stroke volume, leading to a decrease in blood pressure. Hydralazine also blocks an enzyme that helps break down a protein called HIF-1α, which helps stimulate the growth of new blood vessels. By blocking this enzyme, Hydralazine helps promote the growth of new blood vessels.

When to interrupt dosage

The proposed dosage of Hydralazine Hydrochloride is contingent upon the established illness, including Hypertensive emergency, Hypertensive sickness and Pregnancy. The measure shifts, as per the technique of delivery (e.g. Tablet, coated - Oral or Tablet) featured in the table below.

Condition

Dosage

Administration

Hypertensive disease

, 20.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 37.5 mg

, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravascular, Injection, solution - Intramuscular; Intravascular, Intravenous, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intramuscular; Intravascular

Hypertension

, 20.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 37.5 mg

Congestive Heart Failure

, 20.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 37.5 mg

Hypertension

, 20.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 37.5 mg

Warnings

Hydralazine Hydrochloride has three contraindications and should not be combined with the states presented in the following table.Hydralazine Hydrochloride Contraindications

Condition

Risk Level

Notes

Coronary Disease

Do Not Combine

Rheumatic Heart Disease

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Hydralazine may interact with Pulse Frequency

There are 20 known major drug interactions with Hydralazine Hydrochloride.

Common Hydralazine Hydrochloride Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Hydralazine.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Hydralazine.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Hydralazine.

Alpelisib

Major

The metabolism of Alpelisib can be decreased when combined with Hydralazine.

Amifostine

Major

Hydralazine may increase the hypotensive activities of Amifostine.

Hydralazine Hydrochloride Toxicity & Overdose RiskThe lowest toxic dose of a drug in rats is 173-187mg/kg and the highest known dose a human has survived is 10g. Those who overdose on this drug may experience low blood pressure, rapid heart rate, headache, flushing, heart pain, heart attack, abnormal heart rhythms, and shock. Treatments for an overdose include emptying the stomach and activated charcoal, which may cause additional heart rhythm problems and shock. It is important to provide supportive and symptomatic care.