Hydralazine Hydrochloride

Hypertensive crisis, Congestive Heart Failure, Severe Hypertension + 1 more
Treatment
1 FDA approval
20 Active Studies for Hydralazine Hydrochloride

What is Hydralazine Hydrochloride

HydralazineThe Generic name of this drug
Treatment SummaryHydralazine is a medication used to treat high blood pressure and heart failure. It was originally developed in the 1950s to treat malaria and was later discovered to also reduce blood pressure. Hydralazine is not the first line of treatment for these conditions anymore, as newer medications have been developed, but it is still used as an adjunct therapy. Hydralazine hydrochloride was approved by the FDA in 1953.
Apresoline hydrochlorideis the brand name
image of different drug pills on a surface
Hydralazine Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Apresoline hydrochloride
Hydralazine
1953
300

Approved as Treatment by the FDA

Hydralazine, also called Apresoline hydrochloride, is approved by the FDA for 1 uses which include Hypertensive disease .
Hypertensive disease
Helps manage Hypertension, Essential Hypertension

Effectiveness

How Hydralazine Hydrochloride Affects PatientsHydralazine helps to lower blood pressure by relaxing the small muscles in the arteries. It's effects start two to six hours after taking it and can last up to 300mg. People taking this drug should be aware of the possibility of developing a condition called systemic lupus erythematosus.
How Hydralazine Hydrochloride works in the bodyHydralazine relaxes the muscles of the blood vessels, reducing their resistance and allowing more blood to flow. This in turn increases the heart rate and stroke volume, leading to a decrease in blood pressure. Hydralazine also blocks an enzyme that helps break down a protein called HIF-1α, which helps stimulate the growth of new blood vessels. By blocking this enzyme, Hydralazine helps promote the growth of new blood vessels.

When to interrupt dosage

The proposed dosage of Hydralazine Hydrochloride is contingent upon the established illness, including Hypertensive emergency, Hypertensive sickness and Pregnancy. The measure shifts, as per the technique of delivery (e.g. Tablet, coated - Oral or Tablet) featured in the table below.
Condition
Dosage
Administration
Severe Hypertension
, 20.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 37.5 mg
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravascular, Injection, solution - Intramuscular; Intravascular, Intravenous, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intramuscular; Intravascular
Hypertensive disease
, 20.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 37.5 mg
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravascular, Injection, solution - Intramuscular; Intravascular, Intravenous, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intramuscular; Intravascular
Hypertensive crisis
, 20.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 37.5 mg
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravascular, Injection, solution - Intramuscular; Intravascular, Intravenous, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intramuscular; Intravascular
Congestive Heart Failure
, 20.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 37.5 mg
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravascular, Injection, solution - Intramuscular; Intravascular, Intravenous, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intramuscular; Intravascular

Warnings

Hydralazine Hydrochloride has three contraindications and should not be combined with the states presented in the following table.Hydralazine Hydrochloride Contraindications
Condition
Risk Level
Notes
Coronary Artery Disease (CAD)
Do Not Combine
Rheumatic Heart Disease
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Hydralazine may interact with Pulse Frequency
There are 20 known major drug interactions with Hydralazine Hydrochloride.
Common Hydralazine Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Hydralazine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Hydralazine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Hydralazine.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Hydralazine.
Amifostine
Major
Hydralazine may increase the hypotensive activities of Amifostine.
Hydralazine Hydrochloride Toxicity & Overdose RiskThe lowest toxic dose of a drug in rats is 173-187mg/kg and the highest known dose a human has survived is 10g. Those who overdose on this drug may experience low blood pressure, rapid heart rate, headache, flushing, heart pain, heart attack, abnormal heart rhythms, and shock. Treatments for an overdose include emptying the stomach and activated charcoal, which may cause additional heart rhythm problems and shock. It is important to provide supportive and symptomatic care.
image of a doctor in a lab doing drug, clinical research

Hydralazine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Hydralazine Hydrochloride?

352 active clinical trials are assessing the potential of Hydralazine Hydrochloride to address Hypertensive disease, Congestive Heart Failure and Hypertensive crisis.
Condition
Clinical Trials
Trial Phases
Hypertensive crisis
0 Actively Recruiting
Severe Hypertension
0 Actively Recruiting
Hypertensive disease
2 Actively Recruiting
Not Applicable
Congestive Heart Failure
317 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4

Hydralazine Hydrochloride Reviews: What are patients saying about Hydralazine Hydrochloride?

5Patient Review
8/6/2018
Hydralazine Hydrochloride for High Blood Pressure
I had extremely high blood pressure that didn't respond to other treatments. Once I added hydralazine to my regimen, though, my blood pressure normalized and I'm feeling much better now.
5Patient Review
8/13/2019
Hydralazine Hydrochloride for High Blood Pressure
This drug saved my life. There were times when my BP was so high I had to consume alcohol to lower it. Drinking like that only made it high again the next day, but now I no longer have to do that thanks to this medication.
5Patient Review
8/6/2018
Hydralazine Hydrochloride for High Blood Pressure
This treatment was life-saving for me. I have highly resistant hypertension and adding hydralazine to my regimen of valsartan hctz, bystolic, and diltiazem finally normalized my blood pressure.
5Patient Review
8/13/2019
Hydralazine Hydrochloride for High Blood Pressure
This drug was immensely helpful to me and quite literally saved my life. There were points where my blood pressure was so high that the only thing that would lower it was alcohol. However, this created a rebound effect and raised my BP even higher the next day. Thankfully, I no longer have to rely on such unhealthy methods to manage my blood pressure.
4Patient Review
11/18/2018
Hydralazine Hydrochloride for High Blood Pressure
After being diagnosed with post-partum hypertension, my doctor put me on hydralazine. This medication really brought down my blood pressure and I experienced few side effects, like a slightly dry mouth. However, four months later my BP has increased again so I'm switching to losartan.
4Patient Review
2/12/2021
Hydralazine Hydrochloride for High Blood Pressure
As long as I take it consistently, this medication brings my blood pressure down to acceptable levels. I don't care for having to take it 3 times a day, but it's better than having high blood pressure. The side effects are minimal.
4Patient Review
2/12/2021
Hydralazine Hydrochloride for High Blood Pressure
So long as I take this medication regularly, it effectively lowers my blood pressure. It's not ideal that I have to take it three times a day, but it's manageable and definitely preferable to having high blood pressure. The side effects are practically nonexistent, which is a huge step up from amlodipine.
4Patient Review
11/18/2018
Hydralazine Hydrochloride for High Blood Pressure
After being diagnosed with post-partum hypertension, I was prescribed hydralazine. This brought my blood pressure down from 180/100 to 130/80. I have had no major side effects, though a slight dry mouth has been noticeable. However, four months later my blood pressure has gone back up to 140/80, so now I am being switched to losartan.
3.7Patient Review
5/28/2022
Hydralazine Hydrochloride for High Blood Pressure
I developed constipation after taking this medication for two weeks. I've tried everything to relieve it, but nothing has worked so far. This constipation is really affecting my quality of life.
3.7Patient Review
8/15/2018
Hydralazine Hydrochloride for High Blood Pressure
I was hospitalized with acute pancreatitis and they gave me hydralazine instead of my usual high blood pressure meds. Shortly after receving that one dose, I had trouble breathing, a very congested head and nausea. I never want to see that medicine again.
3.7Patient Review
5/28/2022
Hydralazine Hydrochloride for High Blood Pressure
After taking this medication for two weeks as directed, I developed terrible constipation. I've tried all the usual remedies to no avail. This has also twice now caused me to take magnesium citrate, which then negatively affects my gut microbiota. So, not sure if I'll be continuing with this prescription.
3.7Patient Review
8/15/2018
Hydralazine Hydrochloride for High Blood Pressure
After being hospitalized for acute pancreatitis, I was given a single dose of hydralazine. Unfortunately, this led to shortness of breath, congestion, and nausea. Needless to say, I never want to see that medicine again.
3Patient Review
6/11/2020
Hydralazine Hydrochloride for High Blood Pressure
My blood pressure has been more stable since starting this medication, according to my doctor.
3Patient Review
6/11/2020
Hydralazine Hydrochloride for High Blood Pressure
My numbers have been all over the place, but I'm feeling much better than before.
2.7Patient Review
1/15/2020
Hydralazine Hydrochloride for High Blood Pressure
I'm already on one blood pressure medication, and I think my doctor prescribed me another just because they could. I've run out of the second medication, and now I'm wondering if I should take a Hydralazine Tab.
2.7Patient Review
1/15/2020
Hydralazine Hydrochloride for High Blood Pressure
I think doctors sometimes perscribe more medication than is necessary. I'm already on a blood pressure medication, but I've run out and am wondering if I should take a Hydralazine Tab.
2.3Patient Review
2/2/2019
Hydralazine Hydrochloride for High Blood Pressure
While this treatment did help with some of my symptoms, it made my ankles and legs swell terribly. I also experienced fluids pooling in the lower half of body, severe headaches, eye pressure, backaches or kidney aches, decreased urination, feet, and hands freezing from lack of circulation. Additionally, I was constantly tired on it. While it wasn't as bad as some other treatments I've tried, I wouldn't recommend it.
2.3Patient Review
2/2/2019
Hydralazine Hydrochloride for High Blood Pressure
Although this medication did decrease my chest pain, it also caused a number of other unpleasant side effects, such as severe swelling in my ankles and legs, headaches, eye pressure, backaches or kidney aches, decreased urination, and freezing feet and hands. I also felt like I might get a blood clot in my legs from the leg and calf swelling.
2Patient Review
10/30/2021
Hydralazine Hydrochloride for High Blood Pressure
I have taken this drug for two weeks with no decrease in blood pressure and a lot of awful side effects: lightheadedness, vision problems, urine retention ,and weight gain. The doctor said it might take a month to work?
2Patient Review
4/5/2022
Hydralazine Hydrochloride for High Blood Pressure
The side effects were tough to deal with, ranging from nausea and diarrhea to constipation and cramps. I also felt generally ill, weak, and had dry mouth and bad breath.
2Patient Review
10/30/2021
Hydralazine Hydrochloride for High Blood Pressure
I took this medication for two weeks with no change in blood pressure and some really unpleasant side effects, like lightheadedness, vision problems, weight gain, and difficulty urinating. The doctor said it might take a month to work but I don't know if I can handle these side effects for that long.
2Patient Review
4/5/2022
Hydralazine Hydrochloride for High Blood Pressure
The side effects were really tough to deal with. I felt nauseous, constipated or diarrhea all the time and my stomach was always growling and cramping. I generally just felt weak and sick. My mouth was dry all the time and my breath smelled terrible.
1Patient Review
4/28/2019
Hydralazine Hydrochloride for High Blood Pressure
Took one pill and, an hour later, my BP went up to 190 and heart rate to 154. After a trip to the ER (where I had 360 mg of Diltiazem over 12 hours), my heart rate is still 125. I was told by doctors never to take this medication again.
1Patient Review
6/3/2021
Hydralazine Hydrochloride for High Blood Pressure
I would not recommend this blood pressure medication to anyone. Just two weeks after being prescribed it, my BP spiked to an extremely dangerous level. I had to go to the ER and spend two days in the hospital before they could get it under control.
1Patient Review
3/2/2020
Hydralazine Hydrochloride for High Blood Pressure
The side effects of this medicine were really bad. I had headaches, dizziness and diarrhea that wouldn't go away. This medicine was terrible.
1Patient Review
5/4/2021
Hydralazine Hydrochloride for High Blood Pressure
I tried this medication once and had to stop immediately. My heart rate spiked and I got a horrible headache.
1Patient Review
7/23/2022
Hydralazine Hydrochloride for High Blood Pressure
I haven't taken this yet, and based on what I've read about it, I don't think I will. It seems like it would just aggravate the issues I'm already dealing with.
1Patient Review
3/2/2020
Hydralazine Hydrochloride for High Blood Pressure
The side effects of this medicine were really terrible. I had headaches, dizziness and diarrhea that just wouldn't go away. My blood pressure also increased because of it. Overall, I would not recommend this medication to anyone.
1Patient Review
6/3/2021
Hydralazine Hydrochloride for High Blood Pressure
I would urge anyone reading this to avoid this blood pressure medication. Two weeks after I started taking it, my BP spiked dangerously high. I had to go to the ER and ended up staying in the hospital for two days. Thankfully I'm now on a different medication regime, but that experience was really scary.
1Patient Review
4/28/2019
Hydralazine Hydrochloride for High Blood Pressure
Do not take this medication. I had a very bad reaction to it, including high blood pressure and an elevated heart rate. I had to go to the emergency room and was given 360 mg of diltiazem over 12 hours. Even after that, my heart rate is still 125.
1Patient Review
5/4/2021
Hydralazine Hydrochloride for High Blood Pressure
I tried this medication once and had such severe side effects that I will never use it again. My heart rate was dangerously high and I had a terrible headache.
1Patient Review
8/26/2021
Hydralazine Hydrochloride for High Blood Pressure
I have debilitating headaches that nothing seems to help. I'm constantly exhausted, have mental fog and depression, and randomly start crying.
1Patient Review
7/23/2022
Hydralazine Hydrochloride for High Blood Pressure
Based on what I've read, I don't think this medication is right for me. I already take three different medications for my hp, and I don't want to add anything else to the mix if it's not necessary.
1Patient Review
8/26/2021
Hydralazine Hydrochloride for High Blood Pressure
Back headaches have been really bad, to the point where nothing seems to help. I'm also dealing with brain fog, depression and crying spells.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about hydralazine hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of drug is hydralazine hydrochloride?

"Hydralazine is a type of medication known as a vasodilator, which means it helps to widen blood vessels. This makes it easier for blood to flow through the body."

Answered by AI

What are the side effects of hydralazine?

"The following are side effects that may occur as your body adjusts to the medication: headache, pounding/fast heartbeat, loss of appetite, nausea, vomiting, diarrhea, or dizziness. If you experience any of these side effects, tell your doctor or pharmacist."

Answered by AI

What is hydralazine hcl used for?

"Hydralazine is used to lower blood pressure. It is also used to control blood pressure in pregnant women or in emergency situations when blood pressure is extremely high."

Answered by AI

What is the difference between hydralazine and hydralazine hydrochloride?

"Hydralazine relaxes blood vessels to increase blood and oxygen supply to the heart, while reducing its workload. Hydrochlorothiazide is a diuretic that helps reduce water in the body by increasing urine flow."

Answered by AI

Clinical Trials for Hydralazine Hydrochloride

Have you considered Hydralazine Hydrochloride clinical trials? We made a collection of clinical trials featuring Hydralazine Hydrochloride, we think they might fit your search criteria.
Have you considered Hydralazine Hydrochloride clinical trials? We made a collection of clinical trials featuring Hydralazine Hydrochloride, we think they might fit your search criteria.
Have you considered Hydralazine Hydrochloride clinical trials? We made a collection of clinical trials featuring Hydralazine Hydrochloride, we think they might fit your search criteria.