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Assisted Ventilation

VentFirst for Extremely Preterm Infants

Q: How many people are participating in the current clinical investigation?

This trial necessitates the enrollment of 940 qualified individuals. Potential study participants can join in at either University of <a href="https://www.withpower.com/clinical-trials/virginia">Virginia</a>, Charlottesville or <a href="https://www.withpower.com/clinical-trials/oregon">Oregon</a> Health &#x26; Science University, Portland.

Q: In what geographic areas is this clinical trial being conducted?

The trial is actively recruiting both in Charlottesville, Portland and Calgary as well as 11 other sites. The University of <a href="https://www.withpower.com/clinical-trials/virginia">Virginia</a>, <a href="https://www.withpower.com/clinical-trials/oregon">Oregon</a> Health &#x26; Science University and the University of Calgary are <a href="https://www.withpower.com/clinical-trials/all">all</a> officially registered locations for this medical experiment.

Q: Does this trial have an open enrollment period at present?

The clinical trial, which was first announced in June of 2016 and recently updated on July 18th 2022, is still recruiting patients according to information available from clinicaltrials.gov.

N/A

Waitlist Available

Led By Karen Fairchild, MD

Research Sponsored by University of Virginia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at admission to the neonatal intensive care unit

Awards & highlights

Study Summary

This trial will compare the effects of two different methods of providing ventilatory assistance to preterm infants.

Eligible Conditions

Intraventricular Hemorrhage

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 minute, 5 minutes, and 10 minutes after delivery

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 minute, 5 minutes, and 10 minutes after delivery

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 minute, 5 minutes, and 10 minutes after delivery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Intraventricular Hemorrhage on Head Ultrasound or death before 7 days of age

Secondary outcome measures

5 minute Apgar Score <5

Death

Lowest hematocrit in first 24 hours

+3 more

Other outcome measures

Admission hypothermia <36.5°C

Apgar scores

Bronchopulmonary Dysplasia (BPD)

+27 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: VentFirst 120 Seconds Cord ClampingExperimental Treatment1 Intervention

Assisted ventilation (face mask continuous positive airway pressure, CPAP, or positive pressure ventilation, PPV) is provided prior to cord clamping at 120 seconds.

Group II: Standard 30-60 Seconds Cord ClampingActive Control1 Intervention

Standard treatment for extremely preterm infants which is delayed cord clamping 30-60 seconds after birth, and assisted ventilation after cord clamping.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Indiana UniversityOTHER

980 Previous Clinical Trials

982,591 Total Patients Enrolled

Brigham and Women's HospitalOTHER

1,608 Previous Clinical Trials

11,469,307 Total Patients Enrolled

Mayo ClinicOTHER

3,205 Previous Clinical Trials

3,766,214 Total Patients Enrolled

Media Library

VentFirst (Assisted Ventilation) Clinical Trial Eligibility Overview. Trial Name: NCT02742454 — N/A

Intraventricular Hemorrhage Research Study Groups: Standard 30-60 Seconds Cord Clamping, VentFirst 120 Seconds Cord Clamping

Intraventricular Hemorrhage Clinical Trial 2023: VentFirst Highlights & Side Effects. Trial Name: NCT02742454 — N/A

VentFirst (Assisted Ventilation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02742454 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people are participating in the current clinical investigation?

"This trial necessitates the enrollment of 940 qualified individuals. Potential study participants can join in at either University of Virginia, Charlottesville or Oregon Health & Science University, Portland."

Answered by AI

In what geographic areas is this clinical trial being conducted?

"The trial is actively recruiting both in Charlottesville, Portland and Calgary as well as 11 other sites. The University of Virginia, Oregon Health & Science University and the University of Calgary are all officially registered locations for this medical experiment."

Answered by AI

Does this trial have an open enrollment period at present?

"The clinical trial, which was first announced in June of 2016 and recently updated on July 18th 2022, is still recruiting patients according to information available from clinicaltrials.gov."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

VentFirst: A Multicenter RCT of Assisted Ventilation During Delayed Cord Clamping for Extremely Preterm Infants

Karen Fairchild, MD 2016. "VentFirst: A Multicenter RCT of Assisted Ventilation During Delayed Cord Clamping for Extremely Preterm Infants". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02742454.