Dexamethasone for Pneumonia

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Mayo Clinic in Rochester, Rochester, MN
Pneumonia
Dexamethasone - Drug
Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary

In this study, researchers propose a unique (individualized) approach to steroid treatment seeking to give the right dose of steroid to the right patient and at the right time. This study seeks to compare usual care to an individualized steroid dosing strategy by testing a marker of inflammation in the blood called C- reactive protein (CRP). The overall goal is to reduce an individual's exposure to steroids and the risk of potential side effects thereby increasing the potential benefit of using steroids to control inflammation in pneumonia.

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Pneumonia

Study Objectives

1 Primary · 5 Secondary · Reporting Duration: First 5 days of hospitalization or until hospital discharge (whichever is sooner)

Day 5
Adherence to individual treatment rule and CRP-guided corticosteroid treatment
Advanced respiratory support free days
ICU and hospital free days
In-hospital Disease Progression
Mortality
Need for Advanced Respiratory Support

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Other trials for Pneumonia

Side Effects for

Ondansetron
2%Deep Vein Thrombosis
2%Cerebrospinal fluid leak
2%Fever
0%Cerebrovascular Hematoma
This histogram enumerates side effects from a completed 2013 Phase 4 trial (NCT01474915) in the Ondansetron ARM group. Side effects include: Deep Vein Thrombosis with 2%, Cerebrospinal fluid leak with 2%, Fever with 2%, Cerebrovascular Hematoma with 0%.

Trial Design

2 Treatment Groups

Usual Care Group
1 of 2
Individualized dosing strategy
1 of 2
Active Control
Experimental Treatment

24 Total Participants · 2 Treatment Groups

Primary Treatment: Dexamethasone · No Placebo Group · Phase 2

Individualized dosing strategy
Drug
Experimental Group · 1 Intervention: Dexamethasone · Intervention Types: Drug
Usual Care GroupNoIntervention Group · 1 Intervention: Usual Care Group · Intervention Types:
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Dexamethasone
2007
Completed Phase 4
~2420

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: first 5 days of hospitalization or until hospital discharge (whichever is sooner)
Closest Location: Mayo Clinic in Rochester · Rochester, MN
Photo of Rochester 1Photo of Rochester 2Photo of Rochester 3
2021First Recorded Clinical Trial
4 TrialsResearching Pneumonia
503 CompletedClinical Trials

Who is running the clinical trial?

Mayo ClinicLead Sponsor
2,860 Previous Clinical Trials
3,686,137 Total Patients Enrolled
6 Trials studying Pneumonia
467 Patients Enrolled for Pneumonia
Yewande Odeyemi, MBBSPrincipal InvestigatorMayo Clinic

Eligibility Criteria

Age 18+ · All Participants · 2 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You are hospitalized.
You have a diagnosis of community acquired pneumonia.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.