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Respiratory Mechanics for Acute Respiratory Distress Syndrome (ARDS)

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Acute Respiratory Distress Syndrome (ARDS)Respiratory Mechanics - Other
Eligibility
18+
All Sexes
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Study Summary

This trial is examining if setting the ventilator based on measurements of respiratory mechanics can help to reduce Day 60 mortality in patients with acute respiratory distress syndrome (ARDS), in both COVID-19 and non-COVID-19 patients.

Eligible Conditions
  • Acute Respiratory Distress Syndrome (ARDS)

Treatment Effectiveness

Effectiveness Progress

1 of 3

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Study Objectives

1 Primary · 5 Secondary · Reporting Duration: Day 1-7, 14, 21, 28

60 days
All-cause 60-day mortality
Hour 72
The change in biomarker expression
Day 1
Number of patients with organ dysfunction
May exceed 60 days
Duration of ICU and hospital stay
Duration of ventilation
Up to 60 days
Number of patients with barotrauma
Day 28
Mortality at ICU discharge, 28 days, and hospital discharge

Trial Safety

Safety Progress

1 of 3

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1
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2
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2
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Trial Design

2 Treatment Groups

Control
1 of 2
Respiratory Mechanics
1 of 2

Active Control

Experimental Treatment

740 Total Participants · 2 Treatment Groups

Primary Treatment: Respiratory Mechanics · No Placebo Group · N/A

Respiratory Mechanics
Other
Experimental Group · 1 Intervention: Respiratory Mechanics · Intervention Types: Other
Control
Other
ActiveComparator Group · 1 Intervention: Standard Ventilation Strategy · Intervention Types: Other

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: day 1-7, 14, 21, 28

Who is running the clinical trial?

University of TorontoOTHER
633 Previous Clinical Trials
721,084 Total Patients Enrolled
Applied Health Research CentreOTHER
21 Previous Clinical Trials
70,893 Total Patients Enrolled
Unity Health TorontoLead Sponsor
495 Previous Clinical Trials
375,170 Total Patients Enrolled
Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,233 Previous Clinical Trials
24,675,912 Total Patients Enrolled
Laurent Brochard, MDPrincipal InvestigatorUnity Health Toronto
9 Previous Clinical Trials
2,239 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 2 Total Inclusion Criteria

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References

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