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Blood Pressure Management for Kidney and Thyroid Cancer
Study Summary
This trial looks at the effects of intensive blood pressure management in patients with metastatic kidney or thyroid cancer who are starting anti-angiogenic therapy.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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- Your blood pressure is consistently higher than 130 mmHg when measured multiple times.I have not had brain surgery or radiotherapy in the last 2 weeks.I had hepatitis C but have been treated and cured.I have heart disease or am at high risk for heart problems.My kidney function is reduced but not severely (moderate CKD).I am using or willing to use effective birth control or abstain from sex.My brain scans show no cancer growth after treatment for brain metastases.Your platelet count is 100,000 or more per microliter of blood.My blood pressure is high despite taking three or more blood pressure medications.My cancer is advanced kidney or thyroid cancer treated first with specific cancer drugs.Your arm is either too big (over 50 cm) or too small (less than 17 cm) for the blood pressure cuff to work properly.I am of childbearing age and my pregnancy test is positive.Your liver function tests (AST and ALT) are not more than 2.5 times the normal limit at the study site.My hepatitis B virus load is undetectable with treatment.I can take care of myself and am up and about more than half of my waking hours.You have a low count of white blood cells.You have enough white blood cells called neutrophils in your body.I have been treated with an AA-TKI before.I have another cancer that won't affect this trial's treatment.I have received immunotherapy.I have severe kidney issues, including dialysis, high potassium, a transplant, or very low filtration rate.I haven't had major heart issues, strokes, severe bleeding, or lung clots in the last 3 months.
- Group 1: Arm B (usual blood pressure management)
- Group 2: Arm A (intensive systolic blood pressure management)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there numerous centers hosting this research inside the city limits?
"In addition to Aurora Sinai Medical Centre in Milwaukee, Wisconsin and two other medical centres within the state, this study is also recruiting participants from 24 additional sites across the nation."
How many individuals are being accepted into this scientific experiment?
"This medical trial necessitates the inclusion of 60 qualified individuals. People in Milwaukee, Wisconsin and Racine, Missouri are eligible to partake at Aurora Sinai Medical Center and Aurora Cancer Care-Milwaukee respectively."
Is there still capacity to join this research protocol?
"Clinicaltrials.gov shows that this medical research is still in search of suitable participants. The initial posting was on the 1st of September 2020, and it has recently been revised as of the 10th August 2022."
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