← Back to Search

Exercise Training for Heart Failure

N/A

Recruiting

Research Sponsored by University of Texas Southwestern Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

All subjects will be >65 years of age

Controls will be screened carefully for hypertension and cardiac disease, including structural heart and hemodynamically significant obstructive coronary disease, using a history, physical examination, and resting and post-exercise transthoracic echocardiograms

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change in reactive hyperemia after 8 weeks of exercise training

Awards & highlights

Study Summary

This trial will investigate whether targeting peripheral skeletal muscle deficiencies can improve aerobic capacity and exercise tolerance in HFpEF patients.

Who is the study for?

This trial is for people over 65 with heart failure where the heart pumps normally but fills abnormally (HFpEF). They must show signs of heart failure, have a normal ejection fraction (>0.50), and evidence of diastolic dysfunction. Excluded are those with severe lung or advanced heart diseases, certain arrhythmias, heavy exercise habits, recent smokers, kidney issues, or on specific heart medications.Check my eligibility

What is being tested?

The study tests if exercising one leg can improve blood flow to muscles, muscle oxygen use during exercise, and reduce nerve activity that narrows blood vessels in patients with HFpEF. It involves an 8-week knee extensor training program to see if these exercises can enhance overall exercise capacity and oxygen uptake.See study design

What are the potential side effects?

Since the intervention is exercise training focused on one leg's muscles (knee extensors), side effects may include muscle soreness or fatigue post-exercise. However, as it's non-drug therapy for elderly individuals with specific health conditions, risks will be closely monitored.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am older than 65 years.

Select...

I have been thoroughly checked for high blood pressure and heart disease.

Select...

I am over 65 years old and have heart failure with preserved ejection fraction.

Select...

I have heart failure with preserved ejection fraction as per European Guidelines.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change in exercise hyperemia after 8 weeks of exercise training

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change in exercise hyperemia after 8 weeks of exercise training

This trial's timeline: 3 weeks for screening, Varies for treatment, and change in exercise hyperemia after 8 weeks of exercise training for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Muscle sympathetic nervous system activity

VO2 onset kinetics

Secondary outcome measures

Exercise hyperemia

Reactive hyperemia

Trial Design

1Treatment groups

Experimental Treatment

Group I: Exercise trainingExperimental Treatment1 Intervention

8 Weeks exercise training 3x per week 30-40 minutes per session

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Texas Southwestern Medical CenterLead Sponsor

1,045 Previous Clinical Trials

1,053,652 Total Patients Enrolled

22 Trials studying Heart Failure

13,217 Patients Enrolled for Heart Failure

Media Library

Exercise training Clinical Trial Eligibility Overview. Trial Name: NCT03465072 — N/A

Heart Failure Research Study Groups: Exercise training

Heart Failure Clinical Trial 2023: Exercise training Highlights & Side Effects. Trial Name: NCT03465072 — N/A

Exercise training 2023 Treatment Timeline for Medical Study. Trial Name: NCT03465072 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does the age of seventy disqualify individuals from participating in this trial?

"Participants in this scientific endeavour must be aged 65 to 85; 22 research projects are available for those under 18 while 692 trials focus on seniors."

Answered by AI

Could I participate in this clinical research endeavor?

"Eligible prospects for this clinical trial must have a diagnosis of heart failure and be between 65-85 years old. In total, 22 participants are sought out by the study."

Answered by AI

How many research subjects are receiving treatment through this investigation?

"Affirmative. Clinicaltrials.gov contains information indicating that this research is actively recruiting test subjects, having first been posted on February 1st of 2018 and edited most recently on April 5th 2022. 22 individuals need to be enrolled from one medical centre."

Answered by AI

Is there enrollment still open for this research project?

"Current information hosted on clinicaltrials.gov indicates that this medical trial is recruiting participants. It was initially posted in February 2018 and its most recent update occurred in April 2022."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Abnormal Vascular, Metabolic, and Neural Function During Exercise in Heart Failure With Preserved Ejection Fraction

Benjamin Levine 2018. "Abnormal Vascular, Metabolic, and Neural Function During Exercise in Heart Failure With Preserved Ejection Fraction". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03465072.

All > Osteopenia