Tamsulosin for Urinary Retention
(PrePOURTS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The objectives of this study are to determine the feasibility of conducting a full-scale randomized control trial comparing the efficacy of tamsulosin compared to placebo in reducing post-operative urinary retention in people undergoing elective thoracic surgery.
Will I have to stop taking my current medications?
The trial requires that you stop taking tamsulosin or other alpha-blockers at least 3 weeks before joining. If you're on certain medications that affect liver enzymes (like ketoconazole or erythromycin), you may not be eligible to participate.
Is Tamsulosin generally safe for humans?
How does the drug Tamsulosin differ from other treatments for urinary retention?
What data supports the effectiveness of the drug Tamsulosin Hydrochloride for urinary retention?
Research shows that Tamsulosin significantly reduces the risk of acute urinary retention in patients with prostatic adenoma, with an 8-year study indicating a 5.6 times lower risk compared to herbal treatments. Additionally, it improves urinary symptoms and flow rates in patients with bladder outlet obstruction due to benign prostatic hyperplasia.810111213
Who Is on the Research Team?
Rahul Nayal
Principal Investigator
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Are You a Good Fit for This Trial?
This trial is for men aged 40 or older who have had urinary retention before, a prostate symptom score of at least 1, diabetes, and are using thoracic epidural analgesia. They can't join if they're allergic to tamsulosin, recently took alpha-blockers, have a UTI or BPH being treated, neurological bladder issues, past urological surgery or disorders like strictures or cancer.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either tamsulosin or placebo to assess efficacy in reducing post-operative urinary retention
Follow-up
Participants are monitored for safety and effectiveness after treatment, including adverse events and catheter-related outcomes
What Are the Treatments Tested in This Trial?
Interventions
- Tamsulosin Hydrochloride
Tamsulosin Hydrochloride is already approved in United States, European Union, Canada, Japan for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Lawson Health Research Institute
Lead Sponsor
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Lead Sponsor
London Health Sciences Centre Research Institute and Lawson Research Institute of St. Joseph's
Lead Sponsor
London Health Sciences Centre OR Lawson Research Institute of St. Joseph's
Lead Sponsor