Succinylcholine Chloride
General Anesthesia, Tracheal Intubation, Skeletal muscle structure
Treatment
1 Active Study for Succinylcholine Chloride
Treatment for
General Anesthesia
What is Succinylcholine Chloride
Succinylcholine
The Generic name of this drug
Treatment Summary
Succinylcholine is a medication used to temporarily relax the muscles during medical procedures. It is made of two molecules of the neurotransmitter acetylcholine, and is most commonly administered intravenously in the form of a chloride salt. It takes effect within one minute and its effects last for four to six minutes. It is mainly used during intubation and surgical procedures.
Anectine
is the brand name
Succinylcholine Chloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Anectine
Succinylcholine
1952
58
Effectiveness
How Succinylcholine Chloride Affects Patients
Succinylcholine is an intravenous medication that quickly causes muscle paralysis, usually within 60 seconds. It does not affect consciousness or pain sensitivity and must be used with anesthesia. In rare cases, this drug has been linked to cardiac arrest and death in pediatric patients who have undiagnosed skeletal myopathy such as Duchenne's muscular dystrophy. If a pediatric patient experiences cardiac arrest soon after taking succinylcholine, they should be treated for hyperkalemia immediately. It is important to use this drug in children only in emergency situations when there is no alternative medication available.
How Succinylcholine Chloride works in the body
Succinylcholine is a drug that stops muscles from working. It does this by attaching to the receptors in your muscles, leading to a temporary paralysis.
When to interrupt dosage
The advocated dosage of Succinylcholine Chloride is contingent upon the diagnosed condition, including Skeletal muscle structure, General Anesthesia and Tracheal Intubation. The measure of dosage depends on the mode of administration (e.g. Injection, solution - Intramuscular; Intravenous; Parenteral or Liquid - Intravenous) as exhibited in the accompanying table.
Condition
Dosage
Administration
General Anesthesia
, 20.0 mg/mL, 500.0 mg, 100.0 mg/mL
, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Injection, solution, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Solution, Solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution - Intravenous, Parenteral, Injection, solution - Intramuscular; Intravenous, Injection - Parenteral, Injection, Injection - Intramuscular; Intravenous
Tracheal Intubation
, 20.0 mg/mL, 500.0 mg, 100.0 mg/mL
, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Injection, solution, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Solution, Solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution - Intravenous, Parenteral, Injection, solution - Intramuscular; Intravenous, Injection - Parenteral, Injection, Injection - Intramuscular; Intravenous
Skeletal muscle structure
, 20.0 mg/mL, 500.0 mg, 100.0 mg/mL
, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Injection, solution, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Solution, Solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution - Intravenous, Parenteral, Injection, solution - Intramuscular; Intravenous, Injection - Parenteral, Injection, Injection - Intramuscular; Intravenous
Warnings
Succinylcholine Chloride Contraindications
Condition
Risk Level
Notes
Wounds and Injuries
Do Not Combine
Malignant Hyperthermia
Do Not Combine
Muscle Tissue
Do Not Combine
Burns
Do Not Combine
Malignant hyperpyrexia due to anesthesia
Do Not Combine
upper motor neuron lesion
Do Not Combine
Denervation
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Succinylcholine may interact with Pulse Frequency
There are 20 known major drug interactions with Succinylcholine Chloride.
Common Succinylcholine Chloride Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Succinylcholine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Succinylcholine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Succinylcholine is combined with Oliceridine.
Thalidomide
Major
Succinylcholine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Acebutolol
Minor
The risk or severity of hyperkalemia can be increased when Succinylcholine is combined with Acebutolol.
Succinylcholine Chloride Toxicity & Overdose Risk
Taking too much succinylcholine may cause deeper muscle weakness, reduced breathing capacity, and shallow breaths or no breathing at all. Treatment for an overdose involves ensuring the patient can breathe while they recover. In some cases, the overdose may cause the effects of the drug to become more like a different type of medication, leading to stronger respiratory muscle paralysis or weakness.
Succinylcholine Chloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Succinylcholine Chloride?
Presently, there are 4 active trials assessing the efficacy of Succinylcholine Chloride in providing General Anesthesia, Skeletal muscle structure and Tracheal Intubation for the treatment of certain conditions.
Condition
Clinical Trials
Trial Phases
General Anesthesia
1 Actively Recruiting
Phase 4
Tracheal Intubation
0 Actively Recruiting
Skeletal muscle structure
0 Actively Recruiting
Succinylcholine Chloride Reviews: What are patients saying about Succinylcholine Chloride?
1
Patient Review
10/27/2008
Succinylcholine Chloride for Decreased Muscle Tone
1
Patient Review
6/16/2014
Succinylcholine Chloride for Skeletal Muscle Relaxation for Tube Insertion Into Trachea
Patient Q&A Section about succinylcholine chloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What type of muscle relaxant is succinylcholine?
"A depolarizing skeletal muscle relaxant, succinylcholine is used in conjunction with anesthesia and to relax skeletal muscles during intubation, mechanical ventilation, and surgical procedures."
Answered by AI
What is succinylcholine used for?
"Although succinylcholine has been used for rapid sequence induction and brief muscle relaxation procedures since the late 1950s, the drug has serious side effects and a significant number of contraindications."
Answered by AI
What are the effects of succinylcholine chloride on the human body?
"Succinylcholine causes very strong muscle relaxation, which can lead to serious problems with breathing and anaphylaxis in very rare cases."
Answered by AI
What drug class is succinylcholine?
"This medication is given in order to help with tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation."
Answered by AI