Treatment for cell motility

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
cell motility
Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary

An intact pharyngoesophageal reflex is essential to protect the upper airway from aspiration of either mouth contents or regurgitated gastric refluxate. This reflex is essential at protecting the airway in all patients. In patients, while under medication to tolerate endotracheal intubation, it is postulated that an identifiable upper esophageal sphincter and esophageal peristalsis are not present. With the cessation of anesthetics, accompanied by the reversal of nerve block, normal pharyngoesophageal peristaltic activity correlates with awakening the patient from anesthesia. This would be identified by the performance of esophageal manometry. A return of normal verbally stimulated pharyngoesophageal swallowing sequence accurately identifies a safe time to remove endotracheal tubes and/or reverse anesthesia. This verbally stimulated swallowing sequence correlated precisely with the return of objective pharyngoesophageal function.

Treatment Effectiveness

Study Objectives

3 Primary · 3 Secondary · Reporting Duration: The HRM study of the cricopharyngeus will be measured for the 5 minute time period just before planned endotracheal extubation to the time during extubation and for the 5 minute period just after endotracheal extubation.

At the completion of procedure
Number of patients completing study.
During enrollment
Blood coagulation tests
The HRM study of the cricopharyngeus will be measured for the 5 minute time period just before planned endotracheal extubation to the time during extubation and for the 5 minute period just after endotracheal extubation.
Duration of HRM
The change in Basal Pressures will be recorded at the end of procedure.
The Basal Pressures of patients during High-Resolution Motility/Manometry (HRM)
The change in Residual Pressures will be recorded at the end of procedure.
Manometry
The change in Wave Duration will be recorded at the end of procedure.
The Wave Duration of patients during High-Resolution Motility/Manometry (HRM)

Trial Safety

Trial Design

0 Treatment Group

100 Total Participants · 0 Treatment Group

Primary Treatment: Treatment · No Placebo Group · N/A

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: the hrm study of the cricopharyngeus will be measured for the 5 minute time period just before planned endotracheal extubation to the time during extubation and for the 5 minute period just after endotracheal extubation.

Who is running the clinical trial?

University of California, San FranciscoLead Sponsor
2,266 Previous Clinical Trials
11,467,231 Total Patients Enrolled
Stanley J Rogers, MDPrincipal InvestigatorUniversity of California, San Francisco
1 Previous Clinical Trials
40 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 3 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You are willing and able to give informed consent in either English or Spanish.
You have a body mass index (BMI) between 18 and 70 kg/m2.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 4th, 2021

Last Reviewed: November 21st, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.