Nimbex

skeletal muscle relaxation for surgery therapy, skeletal muscle relaxation for mechanical ventilation therapy, Mechanical ventilation + 3 more
Treatment
6 FDA approvals
3 Active Studies for Nimbex

What is Nimbex

CisatracuriumThe Generic name of this drug
Treatment SummaryCisatracurium is a muscle relaxant used to treat muscle spasms. It works by blocking the nerves that control muscle contraction, and can be reversed with other medications that increase the production of a neurotransmitter called acetylcholine. It takes effect more quickly than some other muscle relaxants, and usually lasts for an intermediate amount of time.
Nimbexis the brand name
image of different drug pills on a surface
Nimbex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nimbex
Cisatracurium
1995
50

Approved as Treatment by the FDA

Cisatracurium, otherwise known as Nimbex, is approved by the FDA for 6 uses like skeletal muscle relaxation for surgery therapy and Therapeutic procedure .
skeletal muscle relaxation for surgery therapy
Therapeutic procedure
General Anesthesia
Used in combination with other therapies
facilitate tracheal intubation
Used in combination with other therapies
Mechanical ventilation
skeletal muscle relaxation for mechanical ventilation therapy

Effectiveness

How Nimbex Affects PatientsCisatracurium is a medication used to block nerve signals and reduce muscle movement. A typical dose is 0.05 mg/kg in adults, and it takes effect quickly. It will last for an intermediate amount of time compared to other neuromuscular blocking agents. Taking acetylcholinesterase inhibitors, like neostigmine, can counteract the effects of cisatracurium. However, there is a risk of residual paralysis and seizures when taking it, and it can be made worse by other medications. It is important to follow the instructions of a doctor to avoid serious side effects.
How Nimbex works in the bodyCisatracurium blocks signals from reaching nerve cells. It does this by competing with the chemical acetylcholine, which is responsible for sending signals. When acetylcholine is blocked, signals cannot be sent and the nerve cell does not activate.

When to interrupt dosage

The suggested portion of Nimbex hinges on the determined malady, including skeletal muscle relaxation for surgery therapy, General Anesthesia and Mechanical ventilation. The quantity of dosage is contingent upon the technique of administration (e.g. Liquid or Solution) specified in the table below.
Condition
Dosage
Administration
skeletal muscle relaxation for mechanical ventilation therapy
, 10.0 mg/mL, 2.0 mg/mL, 20.0 mg/mL
Injection, , Intravenous, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid
skeletal muscle relaxation for surgery therapy
, 10.0 mg/mL, 2.0 mg/mL, 20.0 mg/mL
Injection, , Intravenous, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid
General Anesthesia
, 10.0 mg/mL, 2.0 mg/mL, 20.0 mg/mL
Injection, , Intravenous, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid
Therapeutic procedure
, 10.0 mg/mL, 2.0 mg/mL, 20.0 mg/mL
Injection, , Intravenous, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid
facilitate tracheal intubation
, 10.0 mg/mL, 2.0 mg/mL, 20.0 mg/mL
Injection, , Intravenous, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid
Mechanical ventilation
, 10.0 mg/mL, 2.0 mg/mL, 20.0 mg/mL
Injection, , Intravenous, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid

Warnings

Nimbex has three contraindications, and its use should be avoided when any of the conditions in the table below is present.Nimbex Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Nimbex.
Common Nimbex Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Cisatracurium may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Eluxadoline
Major
The risk or severity of constipation can be increased when Cisatracurium is combined with Eluxadoline.
Ethanol
Major
Cisatracurium may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Cisatracurium is combined with Oliceridine.
Secretin human
Major
The therapeutic efficacy of Secretin human can be decreased when used in combination with Cisatracurium.
Nimbex Toxicity & Overdose RiskOverdosing on cisatracurium can cause paralysis that lasts longer than necessary for surgery and anesthesia. The primary treatment for an overdose is to ensure a clear airway and controlled breathing until normal neuromuscular function returns. To aid in recovery, certain medicines may be given once the paralysis begins to wear off. If complete paralysis is present, these medicines should not be used. There is no long-term data available on the effects of cisatracurium on cancer, but some tests have shown that it may cause mutations in mice.
image of a doctor in a lab doing drug, clinical research

Nimbex Novel Uses: Which Conditions Have a Clinical Trial Featuring Nimbex?

Currently, 4 active clinical trials are assessing the utility of Nimbex in providing smooth muscle relaxation in preparation for radiological procedures, skeletal muscle relaxation for mechanical ventilation therapy, as well as General Anesthesia.
Condition
Clinical Trials
Trial Phases
skeletal muscle relaxation for mechanical ventilation therapy
0 Actively Recruiting
General Anesthesia
3 Actively Recruiting
Not Applicable, Phase 3
skeletal muscle relaxation for surgery therapy
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
facilitate tracheal intubation
0 Actively Recruiting
Mechanical ventilation
0 Actively Recruiting

Nimbex Reviews: What are patients saying about Nimbex?

5Patient Review
2/3/2014
Nimbex for Skeletal Muscle Relaxation for Tube Insertion Into Trachea
My infant daughter was given this drug and had a severe allergic reaction (anaphylaxis).
2Patient Review
10/21/2011
Nimbex for Skeletal Muscle Relaxation for Tube Insertion Into Trachea
This treatment didn't work well for me. I saw no improvement in my condition after using it.
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Patient Q&A Section about nimbex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does NIMBEX take to wear off?

"0.15 mg/kg NIMBEX administered during stable opioid/nitrous oxide/oxygen anesthesia will produce maximum neuromuscular blockade in about 3 minutes on average, with a clinically effective block lasting for 36 minutes."

Answered by AI

Is NIMBEX a sedative?

"In adults, cisatracurium can be used to help with general anesthesia or sedation in an intensive care unit. It relaxes skeletal muscles and can help with tracheal intubation and mechanical ventilation."

Answered by AI

What is the drug NIMBEX used for?

"The drug Nimbex is given before surgery in order to relax the muscles and make it easier to insert a breathing tube. Nimbex works by causing the muscles to remain still and relax the throat."

Answered by AI

Is NIMBEX a paralytic?

"If NIMBEX is administered, it can cause paralysis which may then lead to respiratory arrest and death. This is more likely to happen to patients for whom it was not intended."

Answered by AI

Clinical Trials for Nimbex