Limbitrol

Depression, Enterocolitis, Anxiety Disorders + 6 more
Treatment
8 FDA approvals
20 Active Studies for Limbitrol

What is Limbitrol

ChlordiazepoxideThe Generic name of this drug
Treatment SummaryAmitriptyline hydrochloride, also known as Elavil, is a type of antidepressant medication used to treat depression and nerve-related pain. It was first released in 1977 and is manufactured by Sandoz.
Libraxis the brand name
image of different drug pills on a surface
Limbitrol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Librax
Chlordiazepoxide
1966
112

Approved as Treatment by the FDA

Chlordiazepoxide, otherwise known as Librax, is approved by the FDA for 8 uses like Enterocolitis and Irritable Bowel Syndrome .
Enterocolitis
Used to treat acute Enterocolitis in combination with Clidinium
Irritable Bowel Syndrome
Used to treat Irritable Bowel Syndrome (IBS) in combination with Clidinium
acute Enterocolitis
Used to treat acute Enterocolitis in combination with Clidinium
Irritable Bowel Syndrome (IBS)
Used to treat Irritable Bowel Syndrome (IBS) in combination with Clidinium
Depression
Used to treat Depression in combination with Amitriptyline
Peptic Ulcer Disease
Used to treat Peptic Ulcer Disease in combination with Clidinium
Anxiety
Used to treat moderate to severe anxiety in combination with Amitriptyline
moderate to severe symptoms
Used to treat moderate to severe symptoms in combination with Amitriptyline

Effectiveness

How Limbitrol Affects PatientsAmitriptyline is a painkiller and anti-depressant. Clinical trials have found it to be effective in treating post-herpetic neuralgia, diabetic neuropathic pain, neurogenic pain, and chronic non-malignant pain. It may also help with fibromyalgia. Amitriptyline has strong anticholinergic properties that can affect the heart, potentially leading to arrhythmia. Elderly patients may experience orthostatic hypotension and tachycardia when taking normal doses for depression. It can also cause changes in blood sugar levels. Lastly, it can lower the convulsive
How Limbitrol works in the bodyWe don't know exactly how amitriptyline works, but it is thought to increase the levels of serotonin and norepinephrine in the brain. These neurotransmitters are important for regulating mood, and a lack of them can lead to depression. This drug increases their levels, which may explain why it helps improve depressive symptoms. It's unclear if this drug's pain-relieving effects are related to its mood-altering activities or something else.

When to interrupt dosage

The prescribed measure of Limbitrol is contingent upon the diagnosed circumstance, including moderate Agitation, intense agitation and Anxiety. Dosage may also differ as per the strategy of delivery (e.g. Tablet, film coated - Oral or Syrup) detailed in the table below.
Condition
Dosage
Administration
moderate to severe symptoms
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Depression
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Enterocolitis
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Anxiety Disorders
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Irritable Bowel Syndrome
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Peptic Ulcer Disease
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Syndrome
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Anxiety
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Anxiety
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral

Warnings

Limbitrol has four contraindications; thus, it should not be ingested when encountering any of the conditions in the following table.There are 20 known major drug interactions with Limbitrol.
Common Limbitrol Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Deutetrabenazine
Major
The risk or severity of sedation and somnolence can be increased when Chlordiazepoxide is combined with Deutetrabenazine.
Ethanol
Major
Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methadone
Major
Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Chlordiazepoxide is combined with Oliceridine.
Limbitrol Toxicity & Overdose RiskAmitriptyline can be toxic if taken in large doses. If someone takes 750mg or more, they may experience symptoms like low blood pressure, confusion, seizures, dilated pupils, difficulty concentrating, drowsiness, hallucinations, irregular heartbeat, and possibly coma. Taking amitriptyline while pregnant or breastfeeding is not recommended due to the risk to the baby. Animal studies have shown that amitriptyline can affect fertility and may have genotoxic potential. Long-term studies on its carcinogenic effects have not been done yet.
image of a doctor in a lab doing drug, clinical research

Limbitrol Novel Uses: Which Conditions Have a Clinical Trial Featuring Limbitrol?

1230 active trials are currently underway to assess the potential of Limbitrol to alleviate symptoms of Depression, Bulimia Nervosa and Migraine.
Condition
Clinical Trials
Trial Phases
Anxiety Disorders
54 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Enterocolitis
0 Actively Recruiting
Irritable Bowel Syndrome
6 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Early Phase 1
Syndrome
4 Actively Recruiting
Phase 2, Phase 3, Not Applicable
Peptic Ulcer Disease
0 Actively Recruiting
Anxiety
1 Actively Recruiting
Not Applicable
Anxiety
0 Actively Recruiting
Depression
335 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3
moderate to severe symptoms
0 Actively Recruiting

Limbitrol Reviews: What are patients saying about Limbitrol?

5Patient Review
10/26/2009
Limbitrol for Anxiousness associated with Depression
I had a good experience with this medication, taking both the 12.5 mg and 5mg doses. I have Generalized Anxiety Disorder, some depression, and an overactive bladder--all of which significantly improved while I was on Limbitrol. A few months ago, I stopped taking the medication to see how things would go without it; now I'm planning to ask my doctor if we can just try Amitriptlyne to see what happens.
5Patient Review
9/13/2010
Limbitrol for Anxiousness associated with Depression
I've used this treatment for over two decades with great success. It's prevented any recurrence of my depression and has helped me sleep better and manage anxiety. I only need to take a small dose at bedtime, and any side effects like sleepiness or dizziness have gone away after continued use. The only downside is that it can cause weight gain.
5Patient Review
3/10/2008
Limbitrol for Anxiousness associated with Depression
I've been taking this medication for over ten years to treat my migraines. Recently, it's become impossible to find at any local or mail-order pharmacy. The generic, amitriptyline, doesn't work for me. I take amitriptyline with librium, and it's not as effective as limbitrol.
5Patient Review
9/5/2009
Limbitrol for Anxiousness associated with Depression
I've been taking this medication for migraines for a week now. I still get headaches, but they're not migraines anymore (I've only had 3 since starting the drug). I do feel somewhat depressed at times, and find myself eating more than usual!
5Patient Review
12/24/2008
Limbitrol for Anxiousness associated with Depression
Limbitrol has really helped me by reducing my depression and helping me sleep. I no longer cry every day, and I'm feeling much better overall.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about limbitrol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has Limbitrol been discontinued?

"The Limbitrol brand is no longer available in the United States. If there are generic versions of this product that have been approved by the FDA, there may be generic equivalents available."

Answered by AI

What are the side effects of Limbitrol?

"If you experience any of the following rare but very serious side effects, stop taking this medication and consult your doctor or pharmacist immediately: fainting, muscle weakness, unusual tiredness.

Possible side effects from taking this medication include feeling drowsy or dizzy, a dry mouth, blurred vision, constipation, bloating, difficulty urinating, and weight gain. If any of these effects become bothersome, inform your doctor or pharmacist. To reduce the risk of feeling dizzy or faint, stand up slowly when getting up from a sitting or lying position. Seek medical help immediately if you experience any of the following rare but serious side effects while taking this medication: fainting, muscle weakness, or unusual fatigue."

Answered by AI

What is Limbitrol prescribed for?

"LIMBITROL may be useful for treating patients with moderate to severe depression who also have moderate to severe anxiety. LIMBITROL may be more effective and have fewer treatment failures than using amitriptyline or chlordiazepoxide alone."

Answered by AI

Clinical Trials for Limbitrol

Have you considered Limbitrol clinical trials? We made a collection of clinical trials featuring Limbitrol, we think they might fit your search criteria.
Have you considered Limbitrol clinical trials? We made a collection of clinical trials featuring Limbitrol, we think they might fit your search criteria.
Have you considered Limbitrol clinical trials? We made a collection of clinical trials featuring Limbitrol, we think they might fit your search criteria.
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