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What is Limbitrol
ChlordiazepoxideThe Generic name of this drug
Treatment SummaryAmitriptyline hydrochloride, also known as Elavil, is a type of antidepressant medication used to treat depression and nerve-related pain. It was first released in 1977 and is manufactured by Sandoz.
Libraxis the brand name
Limbitrol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Librax
Chlordiazepoxide
1966
112
Approved as Treatment by the FDA
Chlordiazepoxide, otherwise known as Librax, is approved by the FDA for 6 uses like Depression and Enterocolitis .Depression
Used to treat Depression in combination with Amitriptyline
Enterocolitis
Used to treat acute Enterocolitis in combination with Clidinium
Irritable Bowel Syndrome (IBS)
Used to treat Irritable Bowel Syndrome (IBS) in combination with Clidinium
moderate to severe symptoms
Used to treat moderate to severe symptoms in combination with Amitriptyline
Peptic Ulcer Disease
Used to treat Peptic Ulcer Disease in combination with Clidinium
Anxiety
Used to treat moderate to severe anxiety in combination with Amitriptyline
Effectiveness
How Limbitrol Affects PatientsAmitriptyline is a painkiller and anti-depressant. Clinical trials have found it to be effective in treating post-herpetic neuralgia, diabetic neuropathic pain, neurogenic pain, and chronic non-malignant pain. It may also help with fibromyalgia. Amitriptyline has strong anticholinergic properties that can affect the heart, potentially leading to arrhythmia. Elderly patients may experience orthostatic hypotension and tachycardia when taking normal doses for depression. It can also cause changes in blood sugar levels. Lastly, it can lower the convulsive
How Limbitrol works in the bodyWe don't know exactly how amitriptyline works, but it is thought to increase the levels of serotonin and norepinephrine in the brain. These neurotransmitters are important for regulating mood, and a lack of them can lead to depression. This drug increases their levels, which may explain why it helps improve depressive symptoms. It's unclear if this drug's pain-relieving effects are related to its mood-altering activities or something else.
When to interrupt dosage
The prescribed measure of Limbitrol is contingent upon the diagnosed circumstance, including moderate Agitation, intense agitation and Anxiety. Dosage may also differ as per the strategy of delivery (e.g. Tablet, film coated - Oral or Syrup) detailed in the table below.Condition
Dosage
Administration
Enterocolitis
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Irritable Bowel Syndrome (IBS)
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Syndrome
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Anxiety
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Peptic Ulcer Disease
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Anxiety
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Depression
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Anxiety Disorders
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
moderate to severe symptoms
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
Limbitrol has four contraindications; thus, it should not be ingested when encountering any of the conditions in the following table.There are 20 known major drug interactions with Limbitrol.Common Limbitrol Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Deutetrabenazine
Major
The risk or severity of sedation and somnolence can be increased when Chlordiazepoxide is combined with Deutetrabenazine.
Ethanol
Major
Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methadone
Major
Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Chlordiazepoxide is combined with Oliceridine.
Limbitrol Toxicity & Overdose RiskAmitriptyline can be toxic if taken in large doses. If someone takes 750mg or more, they may experience symptoms like low blood pressure, confusion, seizures, dilated pupils, difficulty concentrating, drowsiness, hallucinations, irregular heartbeat, and possibly coma. Taking amitriptyline while pregnant or breastfeeding is not recommended due to the risk to the baby. Animal studies have shown that amitriptyline can affect fertility and may have genotoxic potential. Long-term studies on its carcinogenic effects have not been done yet.
Limbitrol Novel Uses: Which Conditions Have a Clinical Trial Featuring Limbitrol?
1230 active trials are currently underway to assess the potential of Limbitrol to alleviate symptoms of Depression, Bulimia Nervosa and Migraine.Condition
Clinical Trials
Trial Phases
Anxiety Disorders
205 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3, Phase 1, Early Phase 1
moderate to severe symptoms
0 Actively Recruiting
Anxiety
4 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Enterocolitis
0 Actively Recruiting
Depression
696 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Early Phase 1, Phase 4
Anxiety
0 Actively Recruiting
Peptic Ulcer Disease
0 Actively Recruiting
Irritable Bowel Syndrome (IBS)
9 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Syndrome
3 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Limbitrol Reviews: What are patients saying about Limbitrol?
5Patient Review
10/26/2009 I had a good experience with this medication, taking both the 12.5 mg and 5mg doses. I have Generalized Anxiety Disorder, some depression, and an overactive bladder--all of which significantly improved while I was on Limbitrol. A few months ago, I stopped taking the medication to see how things would go without it; now I'm planning to ask my doctor if we can just try Amitriptlyne to see what happens.
5Patient Review
9/13/2010 I've used this treatment for over two decades with great success. It's prevented any recurrence of my depression and has helped me sleep better and manage anxiety. I only need to take a small dose at bedtime, and any side effects like sleepiness or dizziness have gone away after continued use. The only downside is that it can cause weight gain.
5Patient Review
3/10/2008 I've been taking this medication for over ten years to treat my migraines. Recently, it's become impossible to find at any local or mail-order pharmacy. The generic, amitriptyline, doesn't work for me. I take amitriptyline with librium, and it's not as effective as limbitrol.
5Patient Review
9/5/2009 I've been taking this medication for migraines for a week now. I still get headaches, but they're not migraines anymore (I've only had 3 since starting the drug). I do feel somewhat depressed at times, and find myself eating more than usual!
5Patient Review
12/24/2008 Limbitrol has really helped me by reducing my depression and helping me sleep. I no longer cry every day, and I'm feeling much better overall.
5Patient Review
12/3/2012 I've been taking this medication for 15 years and it's always worked well for me. Recently, I tried to stop taking it and experienced terrible itching as a result. Once I started taking the medicine again, the itching stopped.
5Patient Review
8/2/2012 I took this for over 25 years and found it very effective; however, when I tried to switch from this to another drug, I had severe withdrawals as I did not wean myself slowly enough. Mom has taken it for 20+ years and now that she's terminal, the doctor switched her to ativan, supposedly to keep her comfortable. Disastrous! I switched her back to Limbitrol and she is much calmer. Beware of withdrawal!
5Patient Review
10/17/2015 I've been taking this medication for a decade now and it's really helped me. My neurologist said he'd put it in the drinking water if he could! I haven't experienced any negative side effects, which is great.
5Patient Review
5/16/2017 I've been taking this medication on and off for over 25 years, and it's still effective. I don't understand why they would discontinue it; it's a great drug that provides a calming feeling during panic attacks.
5Patient Review
12/21/2020 I'm a computer software analyst, so I always have to be on my toes at work. This medication helps me stay focused and clear-headed while performing my job duties.
4.7Patient Review
10/24/2009 This medication helped to ease my nerves during extreme anxiety attacks.
4.3Patient Review
4/28/2011 I found that I would wake up in the middle of the night after taking this medication, which was around 3 or 4am.
4Patient Review
7/9/2010 Limbitrol has been great for me in reducing the frequency of my migraines. I was having a couple per week, but since starting this medication, I've only had one in the last month. The dry mouth and morning grogginess are manageable side effects.
4Patient Review
11/21/2011 I'm really hoping that Limbitrol hasn't been discontinued. I've been using it for six years and it's been incredibly effective for me. If you have any information on this, please let me know.
Patient Q&A Section about limbitrol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Has Limbitrol been discontinued?
"The Limbitrol brand is no longer available in the United States. If there are generic versions of this product that have been approved by the FDA, there may be generic equivalents available."
Answered by AI
What are the side effects of Limbitrol?
"If you experience any of the following rare but very serious side effects, stop taking this medication and consult your doctor or pharmacist immediately: fainting, muscle weakness, unusual tiredness.
Possible side effects from taking this medication include feeling drowsy or dizzy, a dry mouth, blurred vision, constipation, bloating, difficulty urinating, and weight gain. If any of these effects become bothersome, inform your doctor or pharmacist. To reduce the risk of feeling dizzy or faint, stand up slowly when getting up from a sitting or lying position. Seek medical help immediately if you experience any of the following rare but serious side effects while taking this medication: fainting, muscle weakness, or unusual fatigue."
Answered by AI
What is Limbitrol prescribed for?
"LIMBITROL may be useful for treating patients with moderate to severe depression who also have moderate to severe anxiety. LIMBITROL may be more effective and have fewer treatment failures than using amitriptyline or chlordiazepoxide alone."
Answered by AI