Limbitrol

Depression, Enterocolitis, Anxiety Disorders + 6 more
Treatment
8 FDA approvals
20 Active Studies for Limbitrol

What is Limbitrol

ChlordiazepoxideThe Generic name of this drug
Treatment SummaryAmitriptyline hydrochloride, also known as Elavil, is a type of antidepressant medication used to treat depression and nerve-related pain. It was first released in 1977 and is manufactured by Sandoz.
Libraxis the brand name
image of different drug pills on a surface
Limbitrol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Librax
Chlordiazepoxide
1966
112

Approved as Treatment by the FDA

Chlordiazepoxide, otherwise known as Librax, is approved by the FDA for 8 uses like Enterocolitis and Irritable Bowel Syndrome .
Enterocolitis
Used to treat acute Enterocolitis in combination with Clidinium
Irritable Bowel Syndrome
Used to treat Irritable Bowel Syndrome (IBS) in combination with Clidinium
Irritable Bowel Syndrome (IBS)
Used to treat Irritable Bowel Syndrome (IBS) in combination with Clidinium
acute Enterocolitis
Used to treat acute Enterocolitis in combination with Clidinium
Depression
Used to treat Depression in combination with Amitriptyline
Peptic Ulcer Disease
Used to treat Peptic Ulcer Disease in combination with Clidinium
Anxiety
Used to treat moderate to severe anxiety in combination with Amitriptyline
moderate to severe symptoms
Used to treat moderate to severe symptoms in combination with Amitriptyline

Effectiveness

How Limbitrol Affects PatientsAmitriptyline is a painkiller and anti-depressant. Clinical trials have found it to be effective in treating post-herpetic neuralgia, diabetic neuropathic pain, neurogenic pain, and chronic non-malignant pain. It may also help with fibromyalgia. Amitriptyline has strong anticholinergic properties that can affect the heart, potentially leading to arrhythmia. Elderly patients may experience orthostatic hypotension and tachycardia when taking normal doses for depression. It can also cause changes in blood sugar levels. Lastly, it can lower the convulsive
How Limbitrol works in the bodyWe don't know exactly how amitriptyline works, but it is thought to increase the levels of serotonin and norepinephrine in the brain. These neurotransmitters are important for regulating mood, and a lack of them can lead to depression. This drug increases their levels, which may explain why it helps improve depressive symptoms. It's unclear if this drug's pain-relieving effects are related to its mood-altering activities or something else.

When to interrupt dosage

The prescribed measure of Limbitrol is contingent upon the diagnosed circumstance, including moderate Agitation, intense agitation and Anxiety. Dosage may also differ as per the strategy of delivery (e.g. Tablet, film coated - Oral or Syrup) detailed in the table below.
Condition
Dosage
Administration
moderate to severe symptoms
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Depression
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Enterocolitis
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Anxiety Disorders
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Irritable Bowel Syndrome
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Peptic Ulcer Disease
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Syndrome
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Anxiety
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Anxiety
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated

Warnings

Limbitrol has four contraindications; thus, it should not be ingested when encountering any of the conditions in the following table.There are 20 known major drug interactions with Limbitrol.
Common Limbitrol Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Deutetrabenazine
Major
The risk or severity of sedation and somnolence can be increased when Chlordiazepoxide is combined with Deutetrabenazine.
Ethanol
Major
Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methadone
Major
Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Chlordiazepoxide is combined with Oliceridine.
Limbitrol Toxicity & Overdose RiskAmitriptyline can be toxic if taken in large doses. If someone takes 750mg or more, they may experience symptoms like low blood pressure, confusion, seizures, dilated pupils, difficulty concentrating, drowsiness, hallucinations, irregular heartbeat, and possibly coma. Taking amitriptyline while pregnant or breastfeeding is not recommended due to the risk to the baby. Animal studies have shown that amitriptyline can affect fertility and may have genotoxic potential. Long-term studies on its carcinogenic effects have not been done yet.
image of a doctor in a lab doing drug, clinical research

Limbitrol Novel Uses: Which Conditions Have a Clinical Trial Featuring Limbitrol?

1230 active trials are currently underway to assess the potential of Limbitrol to alleviate symptoms of Depression, Bulimia Nervosa and Migraine.
Condition
Clinical Trials
Trial Phases
Anxiety Disorders
56 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Enterocolitis
0 Actively Recruiting
Irritable Bowel Syndrome
5 Actively Recruiting
Not Applicable, Phase 2, Early Phase 1
Syndrome
4 Actively Recruiting
Phase 2, Phase 3, Not Applicable
Peptic Ulcer Disease
0 Actively Recruiting
Anxiety
1 Actively Recruiting
Not Applicable
Anxiety
0 Actively Recruiting
Depression
306 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3
moderate to severe symptoms
0 Actively Recruiting

Limbitrol Reviews: What are patients saying about Limbitrol?

5Patient Review
10/26/2009
Limbitrol for Anxiousness associated with Depression
I had a good experience with this medication, taking both the 12.5 mg and 5mg doses. I have Generalized Anxiety Disorder, some depression, and an overactive bladder--all of which significantly improved while I was on Limbitrol. A few months ago, I stopped taking the medication to see how things would go without it; now I'm planning to ask my doctor if we can just try Amitriptlyne to see what happens.
5Patient Review
9/13/2010
Limbitrol for Anxiousness associated with Depression
I've used this treatment for over two decades with great success. It's prevented any recurrence of my depression and has helped me sleep better and manage anxiety. I only need to take a small dose at bedtime, and any side effects like sleepiness or dizziness have gone away after continued use. The only downside is that it can cause weight gain.
5Patient Review
3/10/2008
Limbitrol for Anxiousness associated with Depression
I've been taking this medication for over ten years to treat my migraines. Recently, it's become impossible to find at any local or mail-order pharmacy. The generic, amitriptyline, doesn't work for me. I take amitriptyline with librium, and it's not as effective as limbitrol.
5Patient Review
9/5/2009
Limbitrol for Anxiousness associated with Depression
I've been taking this medication for migraines for a week now. I still get headaches, but they're not migraines anymore (I've only had 3 since starting the drug). I do feel somewhat depressed at times, and find myself eating more than usual!
5Patient Review
12/24/2008
Limbitrol for Anxiousness associated with Depression
Limbitrol has really helped me by reducing my depression and helping me sleep. I no longer cry every day, and I'm feeling much better overall.
5Patient Review
12/3/2012
Limbitrol for Anxiousness associated with Depression
I've been taking this medication for 15 years and it's always worked well for me. Recently, I tried to stop taking it and experienced terrible itching as a result. Once I started taking the medicine again, the itching stopped.
5Patient Review
8/2/2012
Limbitrol for Anxiousness associated with Depression
I took this for over 25 years and found it very effective; however, when I tried to switch from this to another drug, I had severe withdrawals as I did not wean myself slowly enough. Mom has taken it for 20+ years and now that she's terminal, the doctor switched her to ativan, supposedly to keep her comfortable. Disastrous! I switched her back to Limbitrol and she is much calmer. Beware of withdrawal!
5Patient Review
10/17/2015
Limbitrol for Anxiousness associated with Depression
I've been taking this medication for a decade now and it's really helped me. My neurologist said he'd put it in the drinking water if he could! I haven't experienced any negative side effects, which is great.
5Patient Review
5/16/2017
Limbitrol for Anxiousness associated with Depression
I've been taking this medication on and off for over 25 years, and it's still effective. I don't understand why they would discontinue it; it's a great drug that provides a calming feeling during panic attacks.
5Patient Review
12/21/2020
Limbitrol for Anxiousness associated with Depression
I'm a computer software analyst, so I always have to be on my toes at work. This medication helps me stay focused and clear-headed while performing my job duties.
4.7Patient Review
10/24/2009
Limbitrol for Anxiousness associated with Depression
This medication helped to ease my nerves during extreme anxiety attacks.
4.3Patient Review
4/28/2011
Limbitrol for Anxiousness associated with Depression
I found that I would wake up in the middle of the night after taking this medication, which was around 3 or 4am.
4Patient Review
7/9/2010
Limbitrol for Anxiousness associated with Depression
Limbitrol has been great for me in reducing the frequency of my migraines. I was having a couple per week, but since starting this medication, I've only had one in the last month. The dry mouth and morning grogginess are manageable side effects.
4Patient Review
11/21/2011
Limbitrol for Anxiousness associated with Depression
I'm really hoping that Limbitrol hasn't been discontinued. I've been using it for six years and it's been incredibly effective for me. If you have any information on this, please let me know.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about limbitrol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has Limbitrol been discontinued?

"The Limbitrol brand is no longer available in the United States. If there are generic versions of this product that have been approved by the FDA, there may be generic equivalents available."

Answered by AI

What are the side effects of Limbitrol?

"If you experience any of the following rare but very serious side effects, stop taking this medication and consult your doctor or pharmacist immediately: fainting, muscle weakness, unusual tiredness.

Possible side effects from taking this medication include feeling drowsy or dizzy, a dry mouth, blurred vision, constipation, bloating, difficulty urinating, and weight gain. If any of these effects become bothersome, inform your doctor or pharmacist. To reduce the risk of feeling dizzy or faint, stand up slowly when getting up from a sitting or lying position. Seek medical help immediately if you experience any of the following rare but serious side effects while taking this medication: fainting, muscle weakness, or unusual fatigue."

Answered by AI

What is Limbitrol prescribed for?

"LIMBITROL may be useful for treating patients with moderate to severe depression who also have moderate to severe anxiety. LIMBITROL may be more effective and have fewer treatment failures than using amitriptyline or chlordiazepoxide alone."

Answered by AI

Clinical Trials for Limbitrol

Image of Stanford Digestive Health Clinic in Redwood City, United States.

MITI-001 for Irritable Bowel Syndrome

18 - 65
All Sexes
Redwood City, CA
While the pathophysiology of diarrhea-predominant irritable bowel syndrome (IBS-D) is complex and heterogeneous, dysbiosis of the gut microbiome is frequently observed, suggesting that a substantial subset of patients with irritable bowel syndrome (IBS) have symptoms that are initiated and/or perpetuated by a microbiome dysfunction. Successful randomized controlled trials (RCT) for IBS-D (Ford 2018; Black 2022) leveraging microbiome-targeted therapies (antibiotics or low microbiome fermentation diets) suggest the gut microbiome is at least partially involved in IBS symptoms. Furthermore, fecal microbiota transplantation (FMT) for patients with IBS-D has demonstrated promising results (El-Salhy 2020), supporting the possibility that altering the microbiome composition could ameliorate IBS-D symptoms. MITI-001 is a transplantable gut bacterial community composed of 157 live bacterial strains, encompassing 79 genera of commensal bacteria, that have been isolated from healthy donor stool, purified, and banked. The hypothesis of the proposed research is that MITI-001 can target the pathophysiologic lesion in a subset of IBS-D patients, restore the altered microbial metabolic process, and thus alleviate IBS-D symptoms.
Phase < 1
Waitlist Available
Stanford Digestive Health Clinic (+1 Sites)Sean P Spencer, MD, PhD
Image of Cedars-Sinai Medical Center in Los Angeles, United States.

Living Well Program for Anxiety in Breast Cancer

18+
Female
Los Angeles, CA
The goal of this study is to evaluate the efficacy and cost-effectiveness of the Living Well Program, a digital therapeutic application with telecoaching support, in breast cancer patients with moderate-to-severe anxiety. The main question the study aims to answer is: does digital cognitive-behavioral therapy-based interventions decrease the overall healthcare costs of patients with stage II to IV breast cancer? The study has one group of participants who will use the Living Well app and telecoaching support. This group will be compared to retroactively matched controls. Over 3 months, patients will complete 21 mental health modules and 5 telecoaching sessions. In the following 3 months, they will complete any outstanding telecoaching sessions and modules while still being monitored, even if they finished all modules and sessions in the first 3 months. The 6 months after that will be the follow-up phase. They will still have access to the Living Well app and may continue to use it, and they will complete the same assessment questionnaires as baseline to identify any changes in their overall mental health.
Waitlist Available
Has No Placebo
Cedars-Sinai Medical CenterScott Irwin, MD
Image of University of California San Diego in La Jolla, United States.

AI Chatbot for Postpartum Loneliness

18+
Female
La Jolla, CA
The goal of this clinical trial is to learn whether a postpartum chatbot powered by generative artificial intelligence (genAI) can help new mothers get better pelvic floor health information and feel less lonely after childbirth. The main questions this study aims to answer are: * Does using the chatbot improve postpartum pelvic floor health knowledge? * Does using the chatbot help reduce feelings of loneliness during the postpartum period? * Does using the chatbot impact pelvic floor symptoms? Researchers will compare standard postpartum care to standard care plus the chatbot. Participants will: Be assigned by chance (like flipping a coin) to standard postpartum care with or without access to the chatbot. If in the chatbot group, participants will receive education and support via the chatbot over a 4-week period. Both groups will complete questionnaires to measure their pelvic floor knowledge, pelvic floor symptoms, feelings of loneliness, depression, infant bonding, perceived social support, adverse childhood experiences, and peri-traumatic distress. The chatbot was created by urogynecology experts in collaboration with UC San Diego computer science and biomedical informatics researchers. The chatbot is designed to give new mothers personalized, evidence-based information and support in real time.
Waitlist Available
Has No Placebo
University of California San Diego
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Akashic Records Sessions for Mental Health

18+
All Sexes
Palm City, FL
The goal of this clinical study is to learn the impact of two Akashic Records sessions on mental health symptoms in adults. We want to see how sessions are linked to stress, anxiety, and depression, and to resilience (ability to bounce back) and feelings of connectedness (to self, community, and humanity). Main questions this study will answer are: After two sessions, what is the impact on stress, anxiety, and depression? After two sessions, what is the impact on resilience and connectedness? How do participants describe their experience of the sessions? After two sessions, what are participants' views of their problems (insight), emotional experiences (impact) and observable behaviors in their daily life? What participants will do: Complete online surveys about their mood at four points: before the first session, before the second session, after the second session, and again 2 months later. Surveys include: DASS-21 (Depression, Anxiety, and Stress Scale) CD-RISC-10 (Connor-Davidson Resilience Scale) WATTS (Connectedness Scale) A short demographic form and satisfaction survey Attend two individual Akashic Records sessions (50-90 minutes each) over private video platform with a licensed clinical social worker (principal investigator) The first 50 participants will also join a one-hour interview with open ended questions with a licensed clinical social worker (co-investigator) about one week after the second session to share their experience in their own words. Who can take part: Adults ages 18 and older who can read and consent in English and who have experienced stress, anxiety, or low mood in the past year. How the research will happen: Sessions are held by secure video call. Participants will also complete private online surveys before, during, and after the sessions. Some participants may be invited to share their experiences in a one-on-one interview. All information is kept private and names are removed before analysis. Risks and benefits: Talking about personal topics may bring up strong emotions. Licensed clinicians conduct sessions, offer support, and provide referrals if needed. Possible benefits include new insights, greater peace or meaning, and improved coping; benefits are not guaranteed. Why this matters: Many people seek spiritual or transpersonal support for emotional concerns. This pilot study will provide early evidence on whether Akashic Records sessions may be a helpful, low-risk option and will guide future research.
Waitlist Available
Has No Placebo
Virtual/ No Physical FacilityCandice S Rasa, LCSW
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Virtual Reality Reward Training for Depression

18+
All Sexes
Los Angeles, CA
The purpose of this study is to compare the effects of enhanced Virtual Reality-Reward Training (eVR-RT) with an active control condition, Virtual Reality-Memory Training (VR-MT), on positive affect and other clinical symptoms. Enhanced VR-Reward Training is a novel intervention aimed at enhancing savoring of positive experiences among individuals with depression and low positive affect through guided imaginal recounting following immersion in positive VR experiences. The current study tests an enhanced version of this training using improved virtual reality technology. Target enrollment is 80 participants with low positive affect, depression, and impaired functioning, who are at least 18 years old, who will be randomly assigned to 7 weeks of either enhanced Virtual Reality-Reward Training (VR-RT) or Virtual Reality-Memory Training (VR-MT). Participants will complete in-person VR sessions, laboratory assessments, self-report questionnaires as part of the study. A subset of 8 participants randomly assigned to VR-RT will complete fMRI scans and EMA surveys. The total length of participation is around 3 months.
Phase 2
Recruiting
University of California, Los Angeles
Have you considered Limbitrol clinical trials? We made a collection of clinical trials featuring Limbitrol, we think they might fit your search criteria.Go to Trials
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Self-Help Intervention for Depression and PTSD

18+
All Sexes
Syracuse, NY
It is important to provide support and resources for the many post-9/11 Veterans with mental health symptoms and poor psychosocial functioning who do not engage in psychotherapy. One of the biggest reasons post-9/11 Veterans do not seek treatment is a preference to handle problems on their own. This study examines a self-help intervention that teaches Veterans healthy coping strategies they can use on their own and how to seek out recovery support services such as mental health treatment or whole-person care if they decide to do so in the future. This study will compare the impact of self-help and standard resources at improving mental health and resource utilization. Two hundred Veterans will complete 6 brief assessments across 40 weeks.
Waitlist Available
Has No Placebo
Syracuse VA Medical Center, Syracuse, NY (+1 Sites)Robyn L. Shepardson, PhD
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Online Parent Education for Child Anxiety

18+
All Sexes
Boston, MA
The investigators are doing this research to test whether parents of children ages 2-7 can better manage their child's anxiety by completing a brief, online, self-guided parent education program. One way to provide anxiety management skills to more children, and to potentially prevent worsening outcomes, is to offer online and self-guided educational programs that parents can complete without a clinician. This randomized trial will evaluate the effects of two brief, online, self-guided parent education programs designed to improve parents' understanding of anxiety and teach parents way to help their children cope with anxiety. Parents will be randomly assigned to one of the three programs. The main aim of the study is to examine whether the parent programs, compared to an educational control reduce parental accommodation of anxiety across a 1-, 4-, and 8-month follow-up period. As a secondary aim, the investigators will explore whether the parent programs reduce children's anxiety symptoms over the 8-month follow-up period. Results will inform the development of a scalable, low-cost model for promoting access to evidence-based treatment to young children.
Recruiting
Online Trial
Massachusetts General Hospital
Have you considered Limbitrol clinical trials? We made a collection of clinical trials featuring Limbitrol, we think they might fit your search criteria.Go to Trials
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