Multihance
Magnetic Resonance Angiography, Vascular Occlusion
Treatment
0 Active Studies for Multihance
Treatment for
Magnetic Resonance Angiography
What is Multihance
Gadobenic acid
The Generic name of this drug
Treatment Summary
Gadobenic acid (commonly known as gadobenate dimeglumine) is a contrast agent used in MRI scans, mainly to image the liver. It can also be used to get a better view of the brain and heart. It is different from other contrast agents as it binds weakly and temporarily to proteins in the blood, which increases its signal intensity for a better image.
MultiHance
is the brand name
Multihance Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
MultiHance
Gadobenic acid
2004
2
Effectiveness
How Multihance Affects Patients
Gadobenate dimeglumine is a type of contrast agent that is similar to gadopentetate dimeglumine. It is taken up by the liver and excreted through the bile, with up to 5% of the dose being eliminated this way. The effect of gadobenate dimeglumine lasts for about an hour and it is not broken down in the body.
How Multihance works in the body
Gadobenate Dimeglumine works with Magnetic Resonance Imaging (MRI) to help create images of the brain. It does this by changing the way protons, which generate a weak magnetic field, behave when exposed to a strong magnetic field. Gadobenate Dimeglumine creates a stronger magnetic field around the protons, which alters their relaxation process and creates an increase in signal intensity. However, it does not cross the blood-brain barrier, so it does not affect normal brain tissue or certain lesions that have not caused an abnormal blood-brain barrier.
When to interrupt dosage
The suggested dose of Multihance is contingent upon the determined condition, like Veno-Occlusive Disease, Magnetic Resonance Angiography and MRI Scan. The amount fluctuates, in accordance with the procedure of delivery outlined in the table below.
Condition
Dosage
Administration
Magnetic Resonance Angiography
, 529.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous
Vascular Occlusion
, 529.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous
Warnings
Multihance has one contraindication, and its use should be avoided if you have any of the conditions detailed in the table below.
Multihance Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Gadobenic Acid may interact with Pulse Frequency
There are 20 known major drug interactions with Multihance.
Common Multihance Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The risk or severity of QTc prolongation can be increased when Gadobenic acid is combined with Amiodarone.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Gadobenic acid is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Gadobenic acid is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Gadobenic acid is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Gadobenic acid is combined with Asenapine.
Multihance Toxicity & Overdose Risk
Overdosing on gadobenate dimeglumine can be damaging to the kidneys, leading to cell death, energy depletion, calcium imbalance, and cell misalignment. This is believed to be caused by an overload of oxidative stress.
Multihance Novel Uses: Which Conditions Have a Clinical Trial Featuring Multihance?
10 active trials are currently in progress to assess the capacity of Multihance to enhance MRI Scans, Veno-Occlusive Disease and Magnetic Resonance Angiography.
Condition
Clinical Trials
Trial Phases
Vascular Occlusion
0 Actively Recruiting
Magnetic Resonance Angiography
0 Actively Recruiting
Multihance Reviews: What are patients saying about Multihance?
1
Patient Review
2/29/2016
Multihance for MRI Scan
1
Patient Review
6/1/2011
Multihance for MRI Scan
Patient Q&A Section about multihance
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What kind of contrast is MultiHance?
"MultiHance is a contrast agent that allows for better diagnostic imaging of the liver for both adults and children above the age of two."
Answered by AI
What are the side effects of MultiHance?
"change in your sense of smell, feeling very sleepy,, feeling very agitated or confused, feeling or being sick,, feeling faint or passing out, feeling muscle weakness,, difficulty speaking,, difficulty swallowing, double vision,, blurred vision,, fits,, drowsiness
headache, dizziness, nausea, vomiting, fever, sweating, feeling unusually hot or cold, dry mouth, unusual or bad taste in your mouth, change in your sense of smell, feeling very sleepy, feeling very agitated or confused, feeling or being sick, feeling faint or passing out, feeling muscle weakness, difficulty speaking, difficulty swallowing, double vision, blurred vision, fits, drowsiness"
Answered by AI
Is MultiHance same as gadolinium?
"MULTIHANCE contains the metal gadolinium. Small amounts of this metal can accumulate in various parts of your body including your brain, bones, and skin, and it can remain there for a prolonged period of time (several months to years)."
Answered by AI
What is MultiHance injection used for?
"MultiHance is a medication that is injected into veins in order to improve the quality of magnetic resonance imaging (MRI) scans of the brain and spine in adults and children over the age of two. It is used to visualize areas of the brain that have an abnormal blood-brain barrier or abnormal vascularity."
Answered by AI