Multihance

Magnetic Resonance Angiography, Vascular Occlusion

Treatment

0 Active Studies for Multihance

Treatment for

Magnetic Resonance Angiography

What is Multihance

Gadobenic acidThe Generic name of this drug

Treatment SummaryGadobenic acid (commonly known as gadobenate dimeglumine) is a contrast agent used in MRI scans, mainly to image the liver. It can also be used to get a better view of the brain and heart. It is different from other contrast agents as it binds weakly and temporarily to proteins in the blood, which increases its signal intensity for a better image.

MultiHanceis the brand name

image of different drug pills on a surface

Multihance Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

MultiHance

Gadobenic acid

2004

Effectiveness

How Multihance Affects PatientsGadobenate dimeglumine is a type of contrast agent that is similar to gadopentetate dimeglumine. It is taken up by the liver and excreted through the bile, with up to 5% of the dose being eliminated this way. The effect of gadobenate dimeglumine lasts for about an hour and it is not broken down in the body.

How Multihance works in the bodyGadobenate Dimeglumine works with Magnetic Resonance Imaging (MRI) to help create images of the brain. It does this by changing the way protons, which generate a weak magnetic field, behave when exposed to a strong magnetic field. Gadobenate Dimeglumine creates a stronger magnetic field around the protons, which alters their relaxation process and creates an increase in signal intensity. However, it does not cross the blood-brain barrier, so it does not affect normal brain tissue or certain lesions that have not caused an abnormal blood-brain barrier.

When to interrupt dosage

The suggested dose of Multihance is contingent upon the determined condition, like Veno-Occlusive Disease, Magnetic Resonance Angiography and MRI Scan. The amount fluctuates, in accordance with the procedure of delivery outlined in the table below.

Condition

Dosage

Administration

Magnetic Resonance Angiography

, 529.0 mg/mL

Intravenous, , Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous

Vascular Occlusion

, 529.0 mg/mL

Intravenous, , Solution, Solution - Intravenous, Injection, solution, Injection, solution - Intravenous

Warnings

Multihance has one contraindication, and its use should be avoided if you have any of the conditions detailed in the table below.Multihance Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Gadobenic Acid may interact with Pulse Frequency

There are 20 known major drug interactions with Multihance.

Common Multihance Drug Interactions

Drug Name

Risk Level

Description

Amiodarone

Major

The risk or severity of QTc prolongation can be increased when Gadobenic acid is combined with Amiodarone.

Anagrelide

Major

The risk or severity of QTc prolongation can be increased when Gadobenic acid is combined with Anagrelide.

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Gadobenic acid is combined with Arsenic trioxide.

Artemether

Major

The risk or severity of QTc prolongation can be increased when Gadobenic acid is combined with Artemether.

Asenapine

Major

The risk or severity of QTc prolongation can be increased when Gadobenic acid is combined with Asenapine.

Multihance Toxicity & Overdose RiskOverdosing on gadobenate dimeglumine can be damaging to the kidneys, leading to cell death, energy depletion, calcium imbalance, and cell misalignment. This is believed to be caused by an overload of oxidative stress.

image of a doctor in a lab doing drug, clinical research

Multihance Novel Uses: Which Conditions Have a Clinical Trial Featuring Multihance?

10 active trials are currently in progress to assess the capacity of Multihance to enhance MRI Scans, Veno-Occlusive Disease and Magnetic Resonance Angiography.

Condition

Clinical Trials

Trial Phases

Vascular Occlusion

0 Actively Recruiting

Magnetic Resonance Angiography

0 Actively Recruiting

Multihance Reviews: What are patients saying about Multihance?

1Patient Review

2/29/2016

Multihance for MRI Scan

Had a severe allergic reaction. My throat started to close and my blood pressure skyrocketed. I'm still experiencing bad side effects like rib pain, headaches, dizziness, and nausea. Please read the side effects before taking this medication. It's been four days and I'm still not feeling better.

1Patient Review

6/1/2011

Multihance for MRI Scan

Unfortunately, I had an allergic reaction to this medication that caused wheezing, sobbing, a racing heart, rash, sneezing, coughing, red eyes, sweating, and itching.

Patient Q&A Section about multihance

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What kind of contrast is MultiHance?

"MultiHance is a contrast agent that allows for better diagnostic imaging of the liver for both adults and children above the age of two."

Answered by AI

What are the side effects of MultiHance?

"change in your sense of smell, feeling very sleepy,, feeling very agitated or confused, feeling or being sick,, feeling faint or passing out, feeling muscle weakness,, difficulty speaking,, difficulty swallowing, double vision,, blurred vision,, fits,, drowsiness

headache, dizziness, nausea, vomiting, fever, sweating, feeling unusually hot or cold, dry mouth, unusual or bad taste in your mouth, change in your sense of smell, feeling very sleepy, feeling very agitated or confused, feeling or being sick, feeling faint or passing out, feeling muscle weakness, difficulty speaking, difficulty swallowing, double vision, blurred vision, fits, drowsiness"

Answered by AI

Is MultiHance same as gadolinium?

"MULTIHANCE contains the metal gadolinium. Small amounts of this metal can accumulate in various parts of your body including your brain, bones, and skin, and it can remain there for a prolonged period of time (several months to years)."

Answered by AI

What is MultiHance injection used for?

"MultiHance is a medication that is injected into veins in order to improve the quality of magnetic resonance imaging (MRI) scans of the brain and spine in adults and children over the age of two. It is used to visualize areas of the brain that have an abnormal blood-brain barrier or abnormal vascularity."

Answered by AI