Torsemide

Oral administration complication, Swollen feet or ankles, induction of Diuresis + 4 more
Treatment
8 FDA approvals
20 Active Studies for Torsemide

What is Torsemide

TorasemideThe Generic name of this drug
Treatment SummaryTorasemide is a prescription drug used to treat high blood pressure. It works by increasing the amount of urine your body produces, which helps to reduce blood pressure. Torasemide was approved by the FDA in 1993 and is a type of pyridine-sulfonylurea medication.
Demadexis the brand name
image of different drug pills on a surface
Torsemide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Demadex
Torasemide
2000
115

Approved as Treatment by the FDA

Torasemide, also known as Demadex, is approved by the FDA for 8 uses which include Heart failure and Edema .
Heart failure
Helps manage Heart Failure
Edema
Helps manage Edema
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Liver Disease
Helps manage Liver Disease
Kidney Diseases
Helps manage Kidney Diseases
Swollen feet or ankles
Helps manage Edema
Chronic Kidney Disease (CKD)
Helps manage Kidney Diseases
Congestive Heart Failure
Helps manage Heart Failure

Effectiveness

How Torsemide Affects PatientsTorasemide has been found to be effective in treating acute kidney failure by increasing urine output, and reducing extracellular fluid volume and blood pressure in those with chronic kidney disease. It also has a potassium-sparing effect, which means it reduces the amount of potassium lost in the urine. Additionally, torasemide helps reduce myocardial fibrosis by decreasing the amount of collagen in the heart. This is thought to be because of a decrease in the hormone aldosterone, which reduces the production of an enzyme that is commonly overproduced in those with heart failure.
How Torsemide works in the bodyTorasemide is a type of diuretic drug, which means it helps your body get rid of excess water and salt. It works by blocking a pump in your kidneys that helps to move sodium, potassium, and chloride ions around. This reduces the amount of oxygen needed in the medullary thick ascending loop of Henle, which is a part of your kidneys. Torasemide can also reduce the activity of angiotensin II, which is a hormone that controls your body's salt and water balance. This then decreases the production of other hormones like aldosterone, TGF-B1 and thrombox

When to interrupt dosage

The amount of Torsemide is contingent upon the perceived malady, such as Edema, Diuresis and Oral administration difficulty. The quantity of dosage fluctuates, as per the technique of administration (e.g. Oral or Tablet) highlighted in the table below.
Condition
Dosage
Administration
Oral administration complication
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
Swollen feet or ankles
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
induction of Diuresis
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
Hypertensive disease
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
Diuresis
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
Chronic Kidney Disease (CKD)
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
Congestive Heart Failure
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral

Warnings

Torsemide Contraindications
Condition
Risk Level
Notes
Anuria
Do Not Combine
Hepatic Encephalopathy
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Torasemide may interact with Pulse Frequency
There are 20 known major drug interactions with Torsemide.
Common Torsemide Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Torasemide.
Amifostine
Major
Torasemide may increase the hypotensive activities of Amifostine.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Torasemide.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Torasemide.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Torasemide.
Torsemide Toxicity & Overdose RiskThe lowest amount of torasemide that is toxic to rats is 5 g/kg. An overdose of torasemide can lead to extreme dehydration, confusion, low blood pressure, and decreased levels of sodium, potassium, and chloride in the body. It may also cause sleepiness, stomach upset, and changes in blood concentration. Torasemide has not been shown to increase the risk of tumors, and it is not known to cause mutations, harm the fetus, or cause birth defects.
image of a doctor in a lab doing drug, clinical research

Torsemide Novel Uses: Which Conditions Have a Clinical Trial Featuring Torsemide?

Currently, 700 active studies are underway to explore the potential of Torsemide to treat Congestive Heart Failure, induce Diuresis and ameliorate Hepatitis.
Condition
Clinical Trials
Trial Phases
Diuresis
0 Actively Recruiting
Swollen feet or ankles
7 Actively Recruiting
Phase 2, Not Applicable
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Chronic Kidney Disease (CKD)
26 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1
Oral administration complication
0 Actively Recruiting
Congestive Heart Failure
176 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
induction of Diuresis
0 Actively Recruiting

Torsemide Reviews: What are patients saying about Torsemide?

4.7Patient Review
9/8/2013
Torsemide for High Blood Pressure
After a stroke, I was prescribed this drug to help with my blood pressure and swelling in my legs. However, the dosage made me dizzy and caused me to pass out until it was halved. Even then, everything still tasted salty, sour, and vinegary. Taking B12 seemed to help stop the taste somewhat.
4.7Patient Review
5/20/2017
Torsemide for Visible Water Retention
I've tried a lot of different treatments for edema, and this one is definitely the best so far. In just three days, I saw a significant reduction in swelling in my ankles and feet, as well as 12 pounds of fluid weight.
4.3Patient Review
8/16/2012
Torsemide for Fluid in the Lungs due to Chronic Heart Failure
I've been using this for a couple months now and I'm not sure if it's working or not. I think my skin might be getting worse? I've noticed more wrinkles and crepey skin, especially on my neck and arms. This is really disappointing because I used to have great skin texture.
4Patient Review
1/20/2014
Torsemide for Visible Water Retention
This treatment is effective at reducing swelling.
3.7Patient Review
5/29/2014
Torsemide for Visible Water Retention
The first time I used this medication, I experienced some pretty severe leg cramps. Additionally, I felt dizzy and weak. The cramps were intense, but thankfully didn't last too long.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about torsemide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Lasix the same as torsemide?

"Furosemide is the most widely used diuretic in heart failure patients, but torsemide has a better pharmacokinetic and pharmacodynamic profile, with greater bioavailability, a longer half-life, and higher potency."

Answered by AI

Does torsemide deplete potassium?

"The medication torsemide can cause decreased levels of potassium, calcium, and magnesium in the blood, which in turn can increase the risk of toxicity from digoxin. Taking torsemide in combination with other diuretics such as metolazone, hydrochlorothiazide, or chlorthalidone can magnify the potassium and magnesium losses."

Answered by AI

What are side effects of torsemide?

"Severe dehydration and electrolyte imbalance are rare but serious side effects of this medication. If you experience any of the following symptoms, tell your doctor right away: muscle cramps, weakness, unusual tiredness, confusion, severe dizziness, fainting, drowsiness, unusual dry mouth/thirst, nausea, vomiting, fast/irregular heartbeat."

Answered by AI

How much torsemide can I take in a day?

"Adults should take 10-20mg of the drug once per day. The dosage can be increased as needed, but should not exceed 200mg per day."

Answered by AI

Clinical Trials for Torsemide

Have you considered Torsemide clinical trials? We made a collection of clinical trials featuring Torsemide, we think they might fit your search criteria.
Have you considered Torsemide clinical trials? We made a collection of clinical trials featuring Torsemide, we think they might fit your search criteria.
Have you considered Torsemide clinical trials? We made a collection of clinical trials featuring Torsemide, we think they might fit your search criteria.
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