Torsemide

Oral administration complication, Swollen feet or ankles, induction of Diuresis + 4 more
Treatment
8 FDA approvals
20 Active Studies for Torsemide

What is Torsemide

TorasemideThe Generic name of this drug
Treatment SummaryTorasemide is a prescription drug used to treat high blood pressure. It works by increasing the amount of urine your body produces, which helps to reduce blood pressure. Torasemide was approved by the FDA in 1993 and is a type of pyridine-sulfonylurea medication.
Demadexis the brand name
image of different drug pills on a surface
Torsemide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Demadex
Torasemide
2000
115

Approved as Treatment by the FDA

Torasemide, also known as Demadex, is approved by the FDA for 8 uses which include Heart failure and Hypertensive disease .
Heart failure
Helps manage Heart Failure
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Edema
Helps manage Edema
Liver Disease
Helps manage Liver Disease
Kidney Diseases
Helps manage Kidney Diseases
Swollen feet or ankles
Helps manage Edema
Chronic Kidney Disease (CKD)
Helps manage Kidney Diseases
Congestive Heart Failure
Helps manage Heart Failure

Effectiveness

How Torsemide Affects PatientsTorasemide has been found to be effective in treating acute kidney failure by increasing urine output, and reducing extracellular fluid volume and blood pressure in those with chronic kidney disease. It also has a potassium-sparing effect, which means it reduces the amount of potassium lost in the urine. Additionally, torasemide helps reduce myocardial fibrosis by decreasing the amount of collagen in the heart. This is thought to be because of a decrease in the hormone aldosterone, which reduces the production of an enzyme that is commonly overproduced in those with heart failure.
How Torsemide works in the bodyTorasemide is a type of diuretic drug, which means it helps your body get rid of excess water and salt. It works by blocking a pump in your kidneys that helps to move sodium, potassium, and chloride ions around. This reduces the amount of oxygen needed in the medullary thick ascending loop of Henle, which is a part of your kidneys. Torasemide can also reduce the activity of angiotensin II, which is a hormone that controls your body's salt and water balance. This then decreases the production of other hormones like aldosterone, TGF-B1 and thrombox

When to interrupt dosage

The amount of Torsemide is contingent upon the perceived malady, such as Edema, Diuresis and Oral administration difficulty. The quantity of dosage fluctuates, as per the technique of administration (e.g. Oral or Tablet) highlighted in the table below.
Condition
Dosage
Administration
Swollen feet or ankles
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Tablet, Oral, Tablet - Oral, Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous, Liquid, Tablet, film coated - Oral, Tablet, film coated
Hypertensive disease
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Tablet, Oral, Tablet - Oral, Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous, Liquid, Tablet, film coated - Oral, Tablet, film coated
induction of Diuresis
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Tablet, Oral, Tablet - Oral, Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous, Liquid, Tablet, film coated - Oral, Tablet, film coated
Oral administration complication
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Tablet, Oral, Tablet - Oral, Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous, Liquid, Tablet, film coated - Oral, Tablet, film coated
Diuresis
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Tablet, Oral, Tablet - Oral, Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous, Liquid, Tablet, film coated - Oral, Tablet, film coated
Chronic Kidney Disease (CKD)
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Tablet, Oral, Tablet - Oral, Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous, Liquid, Tablet, film coated - Oral, Tablet, film coated
Congestive Heart Failure
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Tablet, Oral, Tablet - Oral, Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous, Liquid, Tablet, film coated - Oral, Tablet, film coated

Warnings

Torsemide Contraindications
Condition
Risk Level
Notes
Anuria
Do Not Combine
Hepatic Encephalopathy
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Torasemide may interact with Pulse Frequency
There are 20 known major drug interactions with Torsemide.
Common Torsemide Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Torasemide.
Amifostine
Major
Torasemide may increase the hypotensive activities of Amifostine.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Torasemide.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Torasemide.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Torasemide.
Torsemide Toxicity & Overdose RiskThe lowest amount of torasemide that is toxic to rats is 5 g/kg. An overdose of torasemide can lead to extreme dehydration, confusion, low blood pressure, and decreased levels of sodium, potassium, and chloride in the body. It may also cause sleepiness, stomach upset, and changes in blood concentration. Torasemide has not been shown to increase the risk of tumors, and it is not known to cause mutations, harm the fetus, or cause birth defects.
image of a doctor in a lab doing drug, clinical research

Torsemide Novel Uses: Which Conditions Have a Clinical Trial Featuring Torsemide?

Currently, 700 active studies are underway to explore the potential of Torsemide to treat Congestive Heart Failure, induce Diuresis and ameliorate Hepatitis.
Condition
Clinical Trials
Trial Phases
Diuresis
0 Actively Recruiting
Swollen feet or ankles
5 Actively Recruiting
Phase 2, Not Applicable, Phase 4
Hypertensive disease
27 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Chronic Kidney Disease (CKD)
28 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1, Phase 4
Oral administration complication
0 Actively Recruiting
Congestive Heart Failure
186 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
induction of Diuresis
0 Actively Recruiting

Torsemide Reviews: What are patients saying about Torsemide?

4.7Patient Review
9/8/2013
Torsemide for High Blood Pressure
After a stroke, I was prescribed this drug to help with my blood pressure and swelling in my legs. However, the dosage made me dizzy and caused me to pass out until it was halved. Even then, everything still tasted salty, sour, and vinegary. Taking B12 seemed to help stop the taste somewhat.
4.7Patient Review
5/20/2017
Torsemide for Visible Water Retention
I've tried a lot of different treatments for edema, and this one is definitely the best so far. In just three days, I saw a significant reduction in swelling in my ankles and feet, as well as 12 pounds of fluid weight.
4.3Patient Review
8/16/2012
Torsemide for Fluid in the Lungs due to Chronic Heart Failure
I've been using this for a couple months now and I'm not sure if it's working or not. I think my skin might be getting worse? I've noticed more wrinkles and crepey skin, especially on my neck and arms. This is really disappointing because I used to have great skin texture.
4Patient Review
1/20/2014
Torsemide for Visible Water Retention
This treatment is effective at reducing swelling.
3.7Patient Review
5/29/2014
Torsemide for Visible Water Retention
The first time I used this medication, I experienced some pretty severe leg cramps. Additionally, I felt dizzy and weak. The cramps were intense, but thankfully didn't last too long.
3.7Patient Review
8/31/2017
Torsemide for Visible Water Retention
I found this medication to be more potent than Lasix, in the sense that it made me have to urinate more frequently in the morning.
3.7Patient Review
2/5/2011
Torsemide for Visible Water Retention
3.7Patient Review
1/16/2014
Torsemide for Visible Water Retention
I experience nausea on a daily basis.
3.7Patient Review
3/11/2014
Torsemide for Visible Water Retention
While this treatment did help somewhat, I'm still struggling to get rid of all the excess fluid. If anyone has any suggestions, please let me know.
3.3Patient Review
6/17/2016
Torsemide for High Blood Pressure
I started getting headaches after my doctor prescribed this medication, even though I had told him that I didn't have any problems with headaches previously.
3.3Patient Review
4/26/2011
Torsemide for High Blood Pressure
3Patient Review
7/11/2016
Torsemide for Visible Water Retention
This medication does help to get rid of fluids, but unfortunately it happens too quickly and I found myself having to go to the bathroom 20 or more times per day. This also made me dizzy and caused cramping in my legs and hands.
2.7Patient Review
3/25/2018
Torsemide for Visible Water Retention
I've only been taking this for two days, but my blood sugar suddenly spiked to 598. This is extremely concerning to me as a type 2 diabetic, and I will be contacting my doctor if things don't improve soon.
2.7Patient Review
7/22/2021
Torsemide for Accumulation of Fluid Resulting from Chronic Heart Failure
Unfortunately, I have not seen any reduction in my Edema after taking this medication for three days. However, I have been experiencing severe vertigo and feelings of being unwell.
2.3Patient Review
6/27/2017
Torsemide for Visible Water Retention
Worked decently for around a month, but then started making me pass out for several hours every time I took it. Finally stopped taking it altogether and haven't had any issues since-- though I'm still sick overall. The doctors in that system are terrible and didn't believe me about the medication's side effects. Would not recommend.
2.3Patient Review
7/11/2011
Torsemide for High Blood Pressure
This diuretic does a great job at controlling fluid retention, but unfortunately it also gives me heart palpitations which are very bothersome.
1.7Patient Review
10/13/2019
Torsemide for High Blood Pressure
I have been taking this torsemide for more than one year now my doc has told me to stop it for a while and monitor your blood pressure daily twice for atleast 15 days.The problems which I faced after consuming this medicine is light headedness, weakness, lousyness and vertigo not in the beginning moments but after about 6 months of regular consumption( 10 mg) once in a day.Now since I have stopped it today onwards let's see the results.
1Patient Review
6/16/2017
Torsemide for Visible Water Retention
I had a really negative reaction to this medication. It made my creatinine levels increase, which is very dangerous. I'm glad the doctor took me off of it after only a week.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about torsemide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Lasix the same as torsemide?

"Furosemide is the most widely used diuretic in heart failure patients, but torsemide has a better pharmacokinetic and pharmacodynamic profile, with greater bioavailability, a longer half-life, and higher potency."

Answered by AI

Does torsemide deplete potassium?

"The medication torsemide can cause decreased levels of potassium, calcium, and magnesium in the blood, which in turn can increase the risk of toxicity from digoxin. Taking torsemide in combination with other diuretics such as metolazone, hydrochlorothiazide, or chlorthalidone can magnify the potassium and magnesium losses."

Answered by AI

What are side effects of torsemide?

"Severe dehydration and electrolyte imbalance are rare but serious side effects of this medication. If you experience any of the following symptoms, tell your doctor right away: muscle cramps, weakness, unusual tiredness, confusion, severe dizziness, fainting, drowsiness, unusual dry mouth/thirst, nausea, vomiting, fast/irregular heartbeat."

Answered by AI

How much torsemide can I take in a day?

"Adults should take 10-20mg of the drug once per day. The dosage can be increased as needed, but should not exceed 200mg per day."

Answered by AI

Clinical Trials for Torsemide

Image of Cambride Cardiac Care Centre in Cambridge, Canada.

Finerenone for Heart Failure

18+
All Sexes
Cambridge, Canada
The goal of this clinical trial is to learn if the drug finerenone (Karendia) can improve heart function in participants who are at risk for heart and kidney disease. The main question it aims to answer is whether adding finerenone to standard-of-care heart failure medical therapies will beneficially alter the heart structure and function of people who have risk factors for heart and kidney complications and whose left side of the heart is enlarged. The researchers will compare finerenone to a placebo (a look-alike substance that contains no drug) to see if finerenone improves heart structure and function. Participants will: * take a finerenone or a placebo tablet once a day for 12 months * have a cardiac magnetic resonance imaging (cMRI; a safe, non-invasive scan to measure heart mass, stiffness and function) test at the beginning of the study and 12 months later * visit the clinic after one, three, six and twelve months to assess overall health and/or perform blood or urine tests
Phase 3
Waitlist Available
Cambride Cardiac Care Centre (+2 Sites)Subodh Verma, MD, PhDBayer
Image of Lakeland Regional Hospital in Lakeland, United States.

Furosemide for Heart Failure

18+
All Sexes
Lakeland, FL
The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared to lower urine sodium target and standard of care. The main questions it aims to answer are: 1. Does targeting a higher urine sodium goal achieve greater natriuresis and diuresis? 2. Does targeting a higher urine sodium goal reduce frequency of hospital readmissions? 3. Does targeting a higher urine sodium goal reduce hospital length of stay? Researchers will compare natriuresis-guided arms with standard of care to see if targeting higher natriuresis goals improves significantly over current practice. Participants will submit urine samples at routine intervals after being given diuretics to evaluate urine sodium concentration. If urine sodium is low then diuretic dose will be increased.
Phase 4
Waitlist Available
Lakeland Regional HospitalAnas Bizanti, MD
Have you considered Torsemide clinical trials? We made a collection of clinical trials featuring Torsemide, we think they might fit your search criteria.Go to Trials
Have you considered Torsemide clinical trials? We made a collection of clinical trials featuring Torsemide, we think they might fit your search criteria.Go to Trials
Have you considered Torsemide clinical trials? We made a collection of clinical trials featuring Torsemide, we think they might fit your search criteria.Go to Trials
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Terms of Service·Privacy Policy·Cookies·Security