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What is Torsemide
TorasemideThe Generic name of this drug
Treatment SummaryTorasemide is a prescription drug used to treat high blood pressure. It works by increasing the amount of urine your body produces, which helps to reduce blood pressure. Torasemide was approved by the FDA in 1993 and is a type of pyridine-sulfonylurea medication.
Demadexis the brand name
Torsemide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Demadex
Torasemide
2000
115
Approved as Treatment by the FDA
Torasemide, also known as Demadex, is approved by the FDA for 4 uses which include Congestive Heart Failure and Chronic Kidney Disease (CKD) .Congestive Heart Failure
Helps manage Heart Failure
Chronic Kidney Disease (CKD)
Helps manage Kidney Diseases
Swollen feet or ankles
Helps manage Edema
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Effectiveness
How Torsemide Affects PatientsTorasemide has been found to be effective in treating acute kidney failure by increasing urine output, and reducing extracellular fluid volume and blood pressure in those with chronic kidney disease. It also has a potassium-sparing effect, which means it reduces the amount of potassium lost in the urine. Additionally, torasemide helps reduce myocardial fibrosis by decreasing the amount of collagen in the heart. This is thought to be because of a decrease in the hormone aldosterone, which reduces the production of an enzyme that is commonly overproduced in those with heart failure.
How Torsemide works in the bodyTorasemide is a type of diuretic drug, which means it helps your body get rid of excess water and salt. It works by blocking a pump in your kidneys that helps to move sodium, potassium, and chloride ions around. This reduces the amount of oxygen needed in the medullary thick ascending loop of Henle, which is a part of your kidneys. Torasemide can also reduce the activity of angiotensin II, which is a hormone that controls your body's salt and water balance. This then decreases the production of other hormones like aldosterone, TGF-B1 and thrombox
When to interrupt dosage
The amount of Torsemide is contingent upon the perceived malady, such as Edema, Diuresis and Oral administration difficulty. The quantity of dosage fluctuates, as per the technique of administration (e.g. Oral or Tablet) highlighted in the table below.Condition
Dosage
Administration
Congestive Heart Failure
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
Swollen feet or ankles
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
Oral administration complication
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
induction of Diuresis
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
Chronic Kidney Disease (CKD)
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
Diuresis
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
Hypertensive disease
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
Warnings
Torsemide ContraindicationsCondition
Risk Level
Notes
Anuria
Do Not Combine
Hepatic coma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Torasemide may interact with Pulse Frequency
Common Torsemide Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Torasemide.
Amifostine
Major
Torasemide may increase the hypotensive activities of Amifostine.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Torasemide.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Torasemide.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Torasemide.
Torsemide Toxicity & Overdose RiskThe lowest amount of torasemide that is toxic to rats is 5 g/kg. An overdose of torasemide can lead to extreme dehydration, confusion, low blood pressure, and decreased levels of sodium, potassium, and chloride in the body. It may also cause sleepiness, stomach upset, and changes in blood concentration. Torasemide has not been shown to increase the risk of tumors, and it is not known to cause mutations, harm the fetus, or cause birth defects.
Torsemide Novel Uses: Which Conditions Have a Clinical Trial Featuring Torsemide?
Currently, 700 active studies are underway to explore the potential of Torsemide to treat Congestive Heart Failure, induce Diuresis and ameliorate Hepatitis.Condition
Clinical Trials
Trial Phases
Oral administration complication
0 Actively Recruiting
Swollen feet or ankles
41 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
Chronic Kidney Disease (CKD)
241 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Congestive Heart Failure
313 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Diuresis
0 Actively Recruiting
induction of Diuresis
0 Actively Recruiting
Torsemide Reviews: What are patients saying about Torsemide?
4.7Patient Review
9/8/2013 After a stroke, I was prescribed this drug to help with my blood pressure and swelling in my legs. However, the dosage made me dizzy and caused me to pass out until it was halved. Even then, everything still tasted salty, sour, and vinegary. Taking B12 seemed to help stop the taste somewhat.
4.7Patient Review
5/20/2017 I've tried a lot of different treatments for edema, and this one is definitely the best so far. In just three days, I saw a significant reduction in swelling in my ankles and feet, as well as 12 pounds of fluid weight.
4.3Patient Review
8/16/2012 I've been using this for a couple months now and I'm not sure if it's working or not. I think my skin might be getting worse? I've noticed more wrinkles and crepey skin, especially on my neck and arms. This is really disappointing because I used to have great skin texture.
4Patient Review
1/20/2014 This treatment is effective at reducing swelling.
3.7Patient Review
5/29/2014 The first time I used this medication, I experienced some pretty severe leg cramps. Additionally, I felt dizzy and weak. The cramps were intense, but thankfully didn't last too long.
3.7Patient Review
8/31/2017 I found this medication to be more potent than Lasix, in the sense that it made me have to urinate more frequently in the morning.
3.7Patient Review
2/5/20113.7Patient Review
1/16/2014 I experience nausea on a daily basis.
3.7Patient Review
3/11/2014 While this treatment did help somewhat, I'm still struggling to get rid of all the excess fluid. If anyone has any suggestions, please let me know.
3.3Patient Review
6/17/2016 I started getting headaches after my doctor prescribed this medication, even though I had told him that I didn't have any problems with headaches previously.
3.3Patient Review
4/26/20113Patient Review
7/11/2016 This medication does help to get rid of fluids, but unfortunately it happens too quickly and I found myself having to go to the bathroom 20 or more times per day. This also made me dizzy and caused cramping in my legs and hands.
2.7Patient Review
3/25/2018 I've only been taking this for two days, but my blood sugar suddenly spiked to 598. This is extremely concerning to me as a type 2 diabetic, and I will be contacting my doctor if things don't improve soon.
2.7Patient Review
7/22/2021 Unfortunately, I have not seen any reduction in my Edema after taking this medication for three days. However, I have been experiencing severe vertigo and feelings of being unwell.
2.3Patient Review
6/27/2017 Worked decently for around a month, but then started making me pass out for several hours every time I took it. Finally stopped taking it altogether and haven't had any issues since-- though I'm still sick overall. The doctors in that system are terrible and didn't believe me about the medication's side effects. Would not recommend.
2.3Patient Review
7/11/2011 This diuretic does a great job at controlling fluid retention, but unfortunately it also gives me heart palpitations which are very bothersome.
1.7Patient Review
10/13/2019 I have been taking this torsemide for more than one year now my doc has told me to stop it for a while and monitor your blood pressure daily twice for atleast 15 days.The problems which I faced after consuming this medicine is light headedness, weakness, lousyness and vertigo not in the beginning moments but after about 6 months of regular consumption( 10 mg) once in a day.Now since I have stopped it today onwards let's see the results.
1Patient Review
6/16/2017 I had a really negative reaction to this medication. It made my creatinine levels increase, which is very dangerous. I'm glad the doctor took me off of it after only a week.
Patient Q&A Section about torsemide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Lasix the same as torsemide?
"Furosemide is the most widely used diuretic in heart failure patients, but torsemide has a better pharmacokinetic and pharmacodynamic profile, with greater bioavailability, a longer half-life, and higher potency."
Answered by AI
Does torsemide deplete potassium?
"The medication torsemide can cause decreased levels of potassium, calcium, and magnesium in the blood, which in turn can increase the risk of toxicity from digoxin. Taking torsemide in combination with other diuretics such as metolazone, hydrochlorothiazide, or chlorthalidone can magnify the potassium and magnesium losses."
Answered by AI
What are side effects of torsemide?
"Severe dehydration and electrolyte imbalance are rare but serious side effects of this medication. If you experience any of the following symptoms, tell your doctor right away: muscle cramps, weakness, unusual tiredness, confusion, severe dizziness, fainting, drowsiness, unusual dry mouth/thirst, nausea, vomiting, fast/irregular heartbeat."
Answered by AI
How much torsemide can I take in a day?
"Adults should take 10-20mg of the drug once per day. The dosage can be increased as needed, but should not exceed 200mg per day."
Answered by AI