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What is Midamor
AmilorideThe Generic name of this drug
Treatment SummaryAmiloride is a drug used to prevent the loss of potassium in the body. It works by blocking the reabsorption of sodium in the kidneys, which in turn creates a negative charge that reduces the secretion of potassium and hydrogen ions. Amiloride is usually taken with other diuretics to increase its effectiveness.
Amiloride Hydrochlorideis the brand name
Midamor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Amiloride Hydrochloride
Amiloride
1986
23
Approved as Treatment by the FDA
Amiloride, otherwise called Amiloride Hydrochloride, is approved by the FDA for 4 uses like Congestive Heart Failure and Hypokalemia .Congestive Heart Failure
Used in combination with other therapies
Hypokalemia
kaliuretic diuretics
Hypertensive disease
Effectiveness
How Midamor Affects PatientsAmiloride is a medication used to treat high blood pressure and congestive heart failure. It is an antihypertensive, potassium-sparing diuretic, meaning it helps the body get rid of extra fluids while also helping to keep potassium levels in the blood normal. It is often taken together with other diuretics. High levels of potassium in the blood (hyperkalemia) can occur when taking amiloride, especially if it is combined with ACE inhibitors or spironolactone. People taking this drug should avoid using salt replacements that contain potassium.
How Midamor works in the bodyAmiloride works by preventing sodium from being reabsorbed in the kidneys. This causes sodium and water to be excreted from the body, but it does not reduce potassium levels. Amiloride does this by blocking sodium channels in the distal convoluted tubules and collecting ducts. This reduces the negative charge in the tubular lumen, which stops potassium and hydrogen from being secreted. Amiloride does not need aldosterone to work.
When to interrupt dosage
The proposed dosage of Midamor is contingent upon the diagnosed state, including Metabolic Alkalosis, Bartter's syndrome and Congestive Heart Failure. The measure of dosage is subject to the method of delivery (e.g. Oral or Tablet) enumerated in the table underneath.Condition
Dosage
Administration
Congestive Heart Failure
, 5.0 mg
, Oral, Tablet, Tablet - Oral
kaliuretic diuretics
, 5.0 mg
, Oral, Tablet, Tablet - Oral
Hypertensive disease
, 5.0 mg
, Oral, Tablet, Tablet - Oral
Metabolic Alkalosis
, 5.0 mg
, Oral, Tablet, Tablet - Oral
Nephrolithiasis
, 5.0 mg
, Oral, Tablet, Tablet - Oral
Hypokalemia
, 5.0 mg
, Oral, Tablet, Tablet - Oral
Polyuria
, 5.0 mg
, Oral, Tablet, Tablet - Oral
Bartter's syndrome
, 5.0 mg
, Oral, Tablet, Tablet - Oral
Ascites
, 5.0 mg
, Oral, Tablet, Tablet - Oral
lithium
, 5.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
Midamor possesses four contraindications and should not be consumed in cases of the conditions identified in the table below.Midamor ContraindicationsCondition
Risk Level
Notes
Impaired Renal Function
Do Not Combine
Hyperkalemia
Do Not Combine
potassium supplementation
Do Not Combine
Pulse Frequency
Do Not Combine
Common Midamor Drug Interactions
Drug Name
Risk Level
Description
Cisplatin
Major
The serum concentration of Cisplatin can be increased when it is combined with Amiloride.
Clofarabine
Major
The serum concentration of Clofarabine can be increased when it is combined with Amiloride.
Cyclosporine
Major
The risk or severity of hyperkalemia can be increased when Amiloride is combined with Cyclosporine.
Dalfampridine
Major
The serum concentration of Dalfampridine can be increased when it is combined with Amiloride.
Gentamicin
Major
The serum concentration of Gentamicin can be increased when it is combined with Amiloride.
Midamor Toxicity & Overdose RiskTaking too much amiloride hydrochloride can be dangerous, as the lethal dose in mice is 56 mg/kg and 36 to 85 mg/kg in rats. Signs of overdose include dehydration and an imbalance of electrolytes in the body.
Midamor Novel Uses: Which Conditions Have a Clinical Trial Featuring Midamor?
Presently, 53 active trials are being conducted to assess the utility of Midamor in treating Hypokalemia, Bartter's Syndrome and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Congestive Heart Failure
23 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Polyuria
0 Actively Recruiting
Bartter's syndrome
0 Actively Recruiting
kaliuretic diuretics
0 Actively Recruiting
Nephrolithiasis
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Hypokalemia
0 Actively Recruiting
lithium
0 Actively Recruiting
Metabolic Alkalosis
0 Actively Recruiting
Ascites
10 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2
Midamor Reviews: What are patients saying about Midamor?
3.3Patient Review
11/4/2015 I had a really bad reaction to this medication after consuming alcohol. I was vomiting for hours and ended up in the ER because I couldn't even drink water. They did an endoscopy and found that my throat had closed up. I'm now worried about the long-term side effects of this drug, as they mimic my existing eye conditions.
2.3Patient Review
9/15/2012 I've been urinating frequently, and my muscles have become weak and uncoordinated. This product has not alleviated these issues at all.
Patient Q&A Section about midamor
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What type of diuretic is Midamor?
"Midamor is a water pill that helps prevent your body from absorbing too much salt and keeps your potassium levels from getting too low. It's used to treat or prevent hypokalemia (low potassium levels in the blood) in people with high blood pressure or congestive heart failure."
Answered by AI
Is Midamor a loop diuretic?
"MIDAMOR (amiloride) has been shown to decrease the enhanced urinary excretion of magnesium when used with a thiazide or loop diuretic. MIDAMOR (amiloride) also has potassium-conserving activity in patients receiving kaliuretic-diuretic agents."
Answered by AI
Does Midamor lower potassium?
"Amiloride may cause your body to retain potassium. This is especially likely if you have diabetes, take other diuretics, take medications that can increase potassium in the blood, or if you're over 65."
Answered by AI
What is Midamor used for?
"Amiloride is a medication used to help treat heart conditions like high blood pressure, heart failure, or fluid retention. It is often used in combination with other medications like diuretics and thiazide diuretics. Amiloride can also help to prevent low blood potassium levels that can be caused by other medications."
Answered by AI