Epinephrine for Diabetes

University of Maryland, Baltimore, Baltimore, MD
DiabetesEpinephrine - Drug
Eligibility
18 - 55
All Sexes

Study Summary

This trial will study the effects of epinephrine on the body, specifically how it regulates function and inflammation.

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
Phase < 1

Similar Trials

1
Fluoxetine
1
Glucagon-like peptide-1
1
Glucose clamp

Study Objectives

1 Primary · 0 Secondary · Reporting Duration: From baseline (pre glucose clamp) to end of experiment (time 240 minutes- 2 hours post intervention (glucose clamp))

Hour 2
Flow mediated dilation (FMD) of the brachial artery

Trial Safety

Phase-Based Safety

1 of 3

Similar Trials

1
Fluoxetine
1
Glucagon-like peptide-1
1
Glucose clamp

Side Effects for

No Epinephrine
10%delayed bleeding
This histogram enumerates side effects from a completed 2021 Phase 4 trial (NCT04065451) in the No Epinephrine ARM group. Side effects include: delayed bleeding with 10%.

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 20 Other Conditions
This treatment demonstrated efficacy for 20 other conditions.

Trial Design

4 Treatment Groups

Epinephrine infusion-0.015ug/kg/min
1 of 4
Epinephrine infusion-0.03 ug/kg/min
1 of 4
Epinephrine infusion-0.06 ug/kg/min
1 of 4
Saline infusion
1 of 4

Experimental Treatment

Non-Treatment Group

32 Total Participants · 4 Treatment Groups

Primary Treatment: Epinephrine · Has Placebo Group · Phase < 1

Epinephrine infusion-0.015ug/kg/min
Drug
Experimental Group · 1 Intervention: Epinephrine · Intervention Types: Drug
Epinephrine infusion-0.03 ug/kg/min
Drug
Experimental Group · 1 Intervention: Epinephrine · Intervention Types: Drug
Epinephrine infusion-0.06 ug/kg/min
Drug
Experimental Group · 1 Intervention: Epinephrine · Intervention Types: Drug
Saline infusion
Other
PlaceboComparator Group · 1 Intervention: Saline infusion · Intervention Types: Other
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Epinephrine
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: from baseline (pre glucose clamp) to end of experiment (time 240 minutes- 2 hours post intervention (glucose clamp))

Who is running the clinical trial?

University of Maryland, BaltimoreLead Sponsor
635 Previous Clinical Trials
357,997 Total Patients Enrolled
4 Trials studying Diabetes
23,990 Patients Enrolled for Diabetes
Vanderbilt UniversityOTHER
687 Previous Clinical Trials
6,132,870 Total Patients Enrolled
7 Trials studying Diabetes
1,139 Patients Enrolled for Diabetes
Stephen Davis, MBBSPrincipal InvestigatorUniversity of Maryland, Baltimore

Eligibility Criteria

Age 18 - 55 · All Participants · 1 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a body mass index greater than 21 kg/m².
References

Frequently Asked Questions

For what purpose is Epinephrine typically employed?

"Epinephrine can be used to treat low blood pressure, an unresponsive slow heart rate, and an abnormal dilation of the pupil." - Anonymous Online Contributor

Unverified Answer

Are there any open enrollment opportunities for this research project?

"If you consult clinicaltrials.gov, you'll see that this study is still looking for participants. It was originally posted on June 1st, 2016 but was updated most recently on April 8th, 2022." - Anonymous Online Contributor

Unverified Answer

What is the precedent for Epinephrine clinical trials?

"As of right now, there are 33 on-going Epinephrine trials with 5 in the final Phase 3. A majority of these studies are centred in Baltimore, Maryland, but there are 52 locations in total running these Epinephrine trials." - Anonymous Online Contributor

Unverified Answer

If a potential test subject is younger than 65, will they still be able to participate in this experiment?

"The age range for people who can enroll in this trial are those who are 18 years old or older, but younger than 55 years old." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top