Aspartame for Oral Glucose Tolerance

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Virginia Tech, Blacksburg, VA
Oral Glucose Tolerance+5 More
Non-Nutritive Sweetener Intake and impact on glucose homeostasis - Other
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

Animal and observational research in humans suggest that specific types of non-nutritive sweeteners (NNS) may impair glycemic control. However, whether NNS consumption impacts glucose homeostasis in middle-aged/older adults with prediabetes is unknown, and potential mechanisms by which this could occur have yet to be identified. The overall objective of this R21 proposal is to establish proof-of-concept for alterations in glucose homeostasis following intake of sucralose, but not aspartame, in middle-aged/older adults with prediabetes compared to a eucaloric diet with no NNS.

Eligible Conditions

  • Oral Glucose Tolerance
  • Insulin Sensitivity
  • glucose
  • Tumor Markers

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Oral Glucose Tolerance

Study Objectives

1 Primary · 7 Secondary · Reporting Duration: 6 weeks

6 weeks
24-hour glycemic control
C-reactive protein
Insulin Sensitivity
Interleukin 6
Monocyte chemoattractant protein-1
Oral glucose tolerance
Serum Endotoxin
Tumor Necrosis Factor alpha

Trial Safety

Safety Progress

1 of 3

Other trials for Oral Glucose Tolerance

Trial Design

3 Treatment Groups

Aspartame
1 of 3
Sucralose
1 of 3
No NNS
1 of 3
Active Control
Non-Treatment Group

51 Total Participants · 3 Treatment Groups

Primary Treatment: Aspartame · Has Placebo Group · N/A

No NNS
Other
ShamComparator Group · 1 Intervention: Non-Nutritive Sweetener Intake and impact on glucose homeostasis · Intervention Types: Other
Aspartame
Other
ActiveComparator Group · 1 Intervention: Non-Nutritive Sweetener Intake and impact on glucose homeostasis · Intervention Types: Other
Sucralose
Other
ActiveComparator Group · 1 Intervention: Non-Nutritive Sweetener Intake and impact on glucose homeostasis · Intervention Types: Other

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 6 weeks
Closest Location: Virginia Tech · Blacksburg, VA
Photo of virginia 1Photo of virginia 2Photo of virginia 3
2014First Recorded Clinical Trial
2 TrialsResearching Oral Glucose Tolerance
5 CompletedClinical Trials

Who is running the clinical trial?

Virginia Polytechnic Institute and State UniversityLead Sponsor
108 Previous Clinical Trials
25,483 Total Patients Enrolled
1 Trials studying Oral Glucose Tolerance
51 Patients Enrolled for Oral Glucose Tolerance
Valisa Hedrick, PhDPrincipal InvestigatorVirginia Polytechnic Institute and State University

Eligibility Criteria

Age 18+ · All Participants · 9 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You are willing to pick up food daily and consume foods provided for an 8-week period.
You are consuming less than one serving of non-nutritive sweetener per week.
You have no plans to gain/lose weight or change physical activity level.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.