Aldactazide

Nephrotic Syndrome, Ascites, Hypokalemia + 14 more
Treatment
18 FDA approvals
20 Active Studies for Aldactazide

What is Aldactazide

SpironolactoneThe Generic name of this drug
Treatment SummarySpironolactone is a medication used to treat a range of medical conditions, including heart failure, high blood pressure, and nephrotic syndrome. It works by blocking certain hormones in the body, which helps regulate sodium and water levels in the body. It can also be used off-label to treat hirsutism, female pattern hair loss, adult acne, and as part of medical gender transition. Spironolactone was approved by the FDA in 1960.
Spironolactoneis the brand name
Aldactazide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Spironolactone
Spironolactone
1960
288

Approved as Treatment by the FDA

Spironolactone, also known as Spironolactone, is approved by the FDA for 18 uses such as Ascites and Swollen feet or ankles .
Ascites
Helps manage Ascites
Swollen feet or ankles
Helps manage Edema
chronic heart failure with reduced ejection fraction (NYHA Class IV)
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)
Cirrhosis of the Liver
Helps manage Cirrhosis of the Liver
Congestive Heart Failure (CHF)
Helps manage Congestive Heart Failure (CHF)
idiopathic hyperaldosteronism
Helps manage idiopathic hyperaldosteronism
Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)
Edema
Helps manage Edema
Primary Hyperaldosteronism
Helps manage Primary Hyperaldosteronism
Hypokalemia
Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class III)
Cirrhosis
Helps manage Cirrhosis of the Liver
Hyperaldosteronism
Helps manage Primary Hyperaldosteronism
Nephrotic Syndrome
Helps manage Nephrotic Syndrome
Congestive Heart Failure
Helps manage Congestive Heart Failure (CHF)
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Ascites
Helps manage Ascites
Hyperaldosteronism
Helps manage idiopathic hyperaldosteronism

Effectiveness

How Aldactazide Affects PatientsSpironolactone is a drug that helps the body get rid of extra water and salt while still keeping potassium. It blocks the hormone receptors in the kidneys that control sodium and water levels, leading to higher levels of renin and aldosterone. This drug is similar to the female hormone progesterone, and can cause some progestogenic and antiandrogenic effects.
How Aldactazide works in the bodySpironolactone helps reduce water retention in the body and lower blood pressure. It does this by blocking channels that allow sodium and potassium to be exchanged in the kidneys, leading to increased sodium and water excretion and more potassium retained in the body.

When to interrupt dosage

The measure of Aldactazide is contingent upon the determined malady, including Hypesthesia, Congestive Heart Failure and Cirrhosis. The quantity of dosage fluctuates according to the method of delivery outlined in the table beneath.
Condition
Dosage
Administration
Nephrotic Syndrome
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Ascites
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hypokalemia
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Acne Vulgaris
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hyperaldosteronism
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hyperaldosteronism
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Swollen feet or ankles
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hypesthesia
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hypesthesia
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Congestive Heart Failure
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hirsutism
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hypertensive disease
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hyperaldosteronism
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Cirrhosis
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Edema
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hypertension
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
inadequate response to other therapeutic measures
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated

Warnings

Aldactazide has six contraindications, so it should not be employed in cases of the conditions given in the following table.Aldactazide Contraindications
Condition
Risk Level
Notes
Renal Insufficiency
Do Not Combine
Anuria
Do Not Combine
Acute Kidney Injury
Do Not Combine
Hyperkalemia
Do Not Combine
Pulse Frequency
Do Not Combine
Addison Disease
Do Not Combine
There are 20 known major drug interactions with Aldactazide.
Common Aldactazide Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Spironolactone.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Spironolactone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Spironolactone.
Cyclosporine
Major
The risk or severity of hyperkalemia can be increased when Spironolactone is combined with Cyclosporine.
Dabrafenib
Major
The metabolism of Dabrafenib can be decreased when combined with Spironolactone.
Aldactazide Toxicity & Overdose RiskSymptoms of spironolactone overdose may include drowsiness, confusion, rash, nausea, vomiting, dizziness, or diarrhea. Treating an overdose may involve keeping the patient hydrated, maintaining electrolyte balance, and monitoring vital functions. The highest toxic dose in mice, rats, and rabbits has been found to be greater than 1g/kg. Spironolactone should not be taken during pregnancy as it has been linked to male fetus feminization in animal studies. Breastfeeding mothers should also avoid this drug as it can be passed through breast milk, though no long-term side effects have been studied. Animal studies
image of a doctor in a lab doing drug, clinical research

Aldactazide Novel Uses: Which Conditions Have a Clinical Trial Featuring Aldactazide?

165 active studies are currently being conducted to evaluate the potential of Aldactazide to alleviate Hypokalemia, Hirsutism and Nephrotic Syndrome.
Condition
Clinical Trials
Trial Phases
Nephrotic Syndrome
4 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Hypertension
0 Actively Recruiting
Ascites
3 Actively Recruiting
Not Applicable, Phase 2
Hypesthesia
10 Actively Recruiting
Not Applicable, Phase 1
Cirrhosis
56 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4, Early Phase 1
Congestive Heart Failure
12 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Hirsutism
0 Actively Recruiting
Hypokalemia
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Hyperaldosteronism
0 Actively Recruiting
inadequate response to other therapeutic measures
0 Actively Recruiting
Hyperaldosteronism
0 Actively Recruiting
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Hypesthesia
7 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1
Swollen feet or ankles
7 Actively Recruiting
Phase 2, Not Applicable
Hyperaldosteronism
0 Actively Recruiting
Edema
0 Actively Recruiting

Aldactazide Reviews: What are patients saying about Aldactazide?

5Patient Review
7/7/2009
Aldactazide for High Blood Pressure
The tablets are a bit large, but they're easy to swallow.
4.3Patient Review
11/22/2017
Aldactazide for High Blood Pressure
I unfortunately experienced some intense breast pain while taking this medication.
4Patient Review
2/10/2013
Aldactazide for High Blood Pressure
I was on this medication for a couple years, but I started having stomach pains, dizziness, nausea, sugar elevation, and muscle and joint pain. So I stopped taking it without consulting my doctor first. After only one week off the meds, my joints are almost pain free!
3Patient Review
1/20/2011
Aldactazide for High Blood Pressure
I'm still testing this out to see if there are any negative side effects. So far, so good!
2.7Patient Review
2/24/2014
Aldactazide for High Blood Pressure
My blood pressure has gone down since taking this medication, but my blood sugar and weight have increased. I've been told that I need to lose weight as a result, and now I'm considered borderline diabetic.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about aldactazide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why is Aldactazide a hazardous drug?

"Hydrochlorothiazide may cause low potassium and sodium levels. The risk of low potassium may be increased in patients with cirrhosis, excessive urination, or with the concurrent use of drugs that lower potassium levels."

Answered by AI

What is the drug Aldactazide used for?

"This product is used to treat high blood pressure (hypertension), heart failure, or extra fluid in the body (edema). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems."

Answered by AI

Can Aldactazide cause low potassium?

"If you have low potassium levels, you may experience leg cramps, constipation, irregular heartbeats, increased thirst or urination, numbness or tingling, muscle weakness, or a limp feeling."

Answered by AI

Is Aldactazide the same as spironolactone?

"Aldactazide is a diuretic that is used to treat heart failure, high blood pressure, and swelling due to certain liver or kidney problems. It is a 2-in-1 diuretic that combines two diuretics into a single pill for convenience."

Answered by AI

Clinical Trials for Aldactazide

Have you considered Aldactazide clinical trials? We made a collection of clinical trials featuring Aldactazide, we think they might fit your search criteria.
Have you considered Aldactazide clinical trials? We made a collection of clinical trials featuring Aldactazide, we think they might fit your search criteria.
Have you considered Aldactazide clinical trials? We made a collection of clinical trials featuring Aldactazide, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top