Your session is about to expire
What is Aldactazide
SpironolactoneThe Generic name of this drug
Treatment SummarySpironolactone is a medication used to treat a range of medical conditions, including heart failure, high blood pressure, and nephrotic syndrome. It works by blocking certain hormones in the body, which helps regulate sodium and water levels in the body. It can also be used off-label to treat hirsutism, female pattern hair loss, adult acne, and as part of medical gender transition. Spironolactone was approved by the FDA in 1960.
Spironolactoneis the brand name
Aldactazide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Spironolactone
Spironolactone
1960
288
Approved as Treatment by the FDA
Spironolactone, also known as Spironolactone, is approved by the FDA for 11 uses such as Hypesthesia and Hypokalemia .Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class III)
Hypokalemia
Swollen feet or ankles
Helps manage Edema
Hyperaldosteronism
Helps manage idiopathic hyperaldosteronism
Ascites
Helps manage Ascites
Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Nephrotic Syndrome
Helps manage Nephrotic Syndrome
Congestive Heart Failure
Helps manage Congestive Heart Failure (CHF)
Primary Hyperaldosteronism
Helps manage Primary Hyperaldosteronism
Cirrhosis
Helps manage Cirrhosis of the Liver
Effectiveness
How Aldactazide Affects PatientsSpironolactone is a drug that helps the body get rid of extra water and salt while still keeping potassium. It blocks the hormone receptors in the kidneys that control sodium and water levels, leading to higher levels of renin and aldosterone. This drug is similar to the female hormone progesterone, and can cause some progestogenic and antiandrogenic effects.
How Aldactazide works in the bodySpironolactone helps reduce water retention in the body and lower blood pressure. It does this by blocking channels that allow sodium and potassium to be exchanged in the kidneys, leading to increased sodium and water excretion and more potassium retained in the body.
When to interrupt dosage
The measure of Aldactazide is contingent upon the determined malady, including Hypesthesia, Congestive Heart Failure and Cirrhosis. The quantity of dosage fluctuates according to the method of delivery outlined in the table beneath.Condition
Dosage
Administration
Hirsutism
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Primary Hyperaldosteronism
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hyperaldosteronism
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Secondary hyperaldosteronism
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hypesthesia
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
nonresponsive to antihypertensive monotherapy
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hypesthesia
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Cirrhosis
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Nephrotic Syndrome
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Edema
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Acne
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Congestive Heart Failure
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hypertensive disease
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Swollen feet or ankles
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Ascites
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Hypokalemia
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
inadequate response to other therapeutic measures
50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Topical, Gel - Topical, Gel, Tablet, coated - Oral, Tablet, coated
Warnings
Aldactazide has six contraindications, so it should not be employed in cases of the conditions given in the following table.Aldactazide ContraindicationsCondition
Risk Level
Notes
significant impairment of renal excretory function
Do Not Combine
Anuria
Do Not Combine
Renal Insufficiency, Acute
Do Not Combine
Hyperkalemia
Do Not Combine
Pulse Frequency
Do Not Combine
Addison's Disease
Do Not Combine
Common Aldactazide Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Spironolactone.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Spironolactone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Spironolactone.
Cyclosporine
Major
The risk or severity of hyperkalemia can be increased when Spironolactone is combined with Cyclosporine.
Dabrafenib
Major
The metabolism of Dabrafenib can be decreased when combined with Spironolactone.
Aldactazide Toxicity & Overdose RiskSymptoms of spironolactone overdose may include drowsiness, confusion, rash, nausea, vomiting, dizziness, or diarrhea. Treating an overdose may involve keeping the patient hydrated, maintaining electrolyte balance, and monitoring vital functions. The highest toxic dose in mice, rats, and rabbits has been found to be greater than 1g/kg. Spironolactone should not be taken during pregnancy as it has been linked to male fetus feminization in animal studies. Breastfeeding mothers should also avoid this drug as it can be passed through breast milk, though no long-term side effects have been studied. Animal studies
Aldactazide Novel Uses: Which Conditions Have a Clinical Trial Featuring Aldactazide?
165 active studies are currently being conducted to evaluate the potential of Aldactazide to alleviate Hypokalemia, Hirsutism and Nephrotic Syndrome.Condition
Clinical Trials
Trial Phases
Hypesthesia
8 Actively Recruiting
Not Applicable, Phase 1
Cirrhosis
50 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Acne
6 Actively Recruiting
Phase 4, Early Phase 1, Not Applicable, Phase 1, Phase 2
Hypokalemia
0 Actively Recruiting
Hyperaldosteronism
0 Actively Recruiting
Edema
0 Actively Recruiting
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
nonresponsive to antihypertensive monotherapy
0 Actively Recruiting
Primary Hyperaldosteronism
0 Actively Recruiting
Ascites
10 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2
inadequate response to other therapeutic measures
0 Actively Recruiting
Nephrotic Syndrome
11 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Secondary hyperaldosteronism
0 Actively Recruiting
Hypesthesia
5 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1
Congestive Heart Failure
23 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Hirsutism
0 Actively Recruiting
Aldactazide Reviews: What are patients saying about Aldactazide?
5Patient Review
7/7/2009 The tablets are a bit large, but they're easy to swallow.
4.3Patient Review
11/22/2017 I unfortunately experienced some intense breast pain while taking this medication.
4Patient Review
2/10/2013 I was on this medication for a couple years, but I started having stomach pains, dizziness, nausea, sugar elevation, and muscle and joint pain. So I stopped taking it without consulting my doctor first. After only one week off the meds, my joints are almost pain free!
3Patient Review
1/20/2011 I'm still testing this out to see if there are any negative side effects. So far, so good!
2.7Patient Review
2/24/2014 My blood pressure has gone down since taking this medication, but my blood sugar and weight have increased. I've been told that I need to lose weight as a result, and now I'm considered borderline diabetic.
2.3Patient Review
10/22/2007Patient Q&A Section about aldactazide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why is Aldactazide a hazardous drug?
"Hydrochlorothiazide may cause low potassium and sodium levels. The risk of low potassium may be increased in patients with cirrhosis, excessive urination, or with the concurrent use of drugs that lower potassium levels."
Answered by AI
What is the drug Aldactazide used for?
"This product is used to treat high blood pressure (hypertension), heart failure, or extra fluid in the body (edema). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems."
Answered by AI
Can Aldactazide cause low potassium?
"If you have low potassium levels, you may experience leg cramps, constipation, irregular heartbeats, increased thirst or urination, numbness or tingling, muscle weakness, or a limp feeling."
Answered by AI
Is Aldactazide the same as spironolactone?
"Aldactazide is a diuretic that is used to treat heart failure, high blood pressure, and swelling due to certain liver or kidney problems. It is a 2-in-1 diuretic that combines two diuretics into a single pill for convenience."
Answered by AI