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What is Metolazone
MetolazoneThe Generic name of this drug
Treatment SummaryMetolazone is a long-acting diuretic used to treat chronic renal failure. It helps reduce blood pressure and causes the body to lose potassium. It belongs to a class of drugs called quinazoline-sulfonamides, which are similar to thiazide diuretics.
Metolazoneis the brand name
Metolazone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Metolazone
Metolazone
1973
81
Approved as Treatment by the FDA
Metolazone, also known as Metolazone, is approved by the FDA for 2 uses which include Hypertensive disease and Hypertensive disease .Hypertensive disease
Used in combination with Hydrochlorothiazide / Losartan to help manage High Blood Pressure (Hypertension)
Hypertensive disease
Helps manage moderate Hypertension
Effectiveness
How Metolazone Affects PatientsMetolazone is a diuretic, which helps the body get rid of excess fluid. It works in a similar way to thiazide diuretics. Studies have shown that metolazone increases the amount of phosphate, magnesium, and sodium that is excreted from the body in people with poor kidney function. It has also been shown to work on animals in laboratory studies.
How Metolazone works in the bodyMetolazone affects how the kidney reabsorbs electrolytes, specifically sodium and chloride. It prevents the absorption of these electrolytes, which causes increased excretion of them in urine. This also increases the amount of potassium that is excreted in urine. Metolazone does not affect carbonic anhydrase. The exact way that metolazone helps lower blood pressure is not known, but it is thought to be related to its effects on electrolyte excretion.
When to interrupt dosage
The measure of Metolazone is contingent upon the diagnosed affliction, including Mild Hypertension, Hypertensive disease and Hypertensive disease. The dosage amount is contingent upon the methodology of delivery featured in the table beneath.Condition
Dosage
Administration
Swollen feet or ankles
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Oral, Tablet, Tablet - Oral
Hypertensive disease
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Oral, Tablet, Tablet - Oral
Chronic Kidney Disease (CKD)
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Oral, Tablet, Tablet - Oral
Congestive Heart Failure
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Oral, Tablet, Tablet - Oral
Mild Hypertension
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Oral, Tablet, Tablet - Oral
Hypertensive disease
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Oral, Tablet, Tablet - Oral
Warnings
Metolazone has three contraindications, and it should be avoided for the conditions listed in the table below.Metolazone ContraindicationsCondition
Risk Level
Notes
Anuria
Do Not Combine
Hepatic coma
Do Not Combine
precoma
Do Not Combine
Common Metolazone Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Metolazone may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Metolazone is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Metolazone is combined with Dofetilide.
Hexamethonium
Major
The risk or severity of adverse effects can be increased when Metolazone is combined with Hexamethonium.
Lithium carbonate
Major
Metolazone may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
Metolazone Toxicity & Overdose RiskOverdosing on this drug can cause difficulty breathing, dizziness, feeling faint upon standing, drowsiness, stomach and intestinal irritation, and extreme fatigue which can lead to a coma.
Metolazone Novel Uses: Which Conditions Have a Clinical Trial Featuring Metolazone?
Presently, 314 active studies are being conducted to examine the potential of Metolazone in treating Congestive Heart Failure, Hypertension and Swelling.Condition
Clinical Trials
Trial Phases
Swollen feet or ankles
41 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
Chronic Kidney Disease (CKD)
241 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Mild Hypertension
0 Actively Recruiting
Hypertensive disease
0 Actively Recruiting
Congestive Heart Failure
22 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Metolazone Reviews: What are patients saying about Metolazone?
5Patient Review
9/11/2012 This pill is very effective at removing fluid. I take it once a week as instructed, and I can really see (and feel) the difference.
5Patient Review
1/17/2018 This diuretic has worked very well for me. I started seeing results within a few days, and my potassium levels dropped after about a week.
5Patient Review
5/11/2012 I am so thankful that this medication exists! Not only did it lower my blood pressure, but the edema in my ankles and feet completely disappeared.
5Patient Review
7/11/2010 This drug was added to my regimen when I needed additional help.
5Patient Review
12/8/2009 This pill is for depression and it has a letter 'M' and the #645 on one side of the pill. The other side is blank. I'm not sure if this is the right pill for my daughter.
4.7Patient Review
12/18/2009 This drug, in combination with lasix, has been working great for me. I have stage 4 kidney failure as well as COPD and congestive heart failure, so this two-drug combo is essential for keeping my lungs and heart functioning properly. When my blood work starts to show that my kidneys are failing, I take a break from the duo for a couple weeks.
4.3Patient Review
1/9/2010 This treatment appears to be effective.
3.7Patient Review
4/6/2013 I've only been on a small dose of this medication, but it has already helped me. However, my heart rate is now irregular. I'm wondering if this is something I will get used to after awhile?
3.7Patient Review
12/29/2009 I take this for congestive heart failure alongside lasix and aldactone. It's helped a little bit, but I'm on such a low dose (2.5mg) that it might just need to be increased. Within two days, it noticeably reduces bloating.
1.7Patient Review
11/27/2020 Metolazone is really not a good choice, especially if you're looking at long-term use. I have to take it for fluid buildup and every time my potassium levels drop critically low, which has led to acute kidney failure in the past. However, I don't have any other choice because the Torsemide that I take daily has all but stopped working. If you can avoid this drug, it would be best for you.
Patient Q&A Section about metolazone
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects for metolazone?
"The following are symptoms of dehydration: dizziness, weakness, restlessness, headache, muscle cramps, joint pain or swelling, constipation, diarrhea."
Answered by AI
Is metolazone a potassium sparing diuretic?
"Metolazone prevents the reabsorption of sodium, potassium, and water in the tubules, causing an increase in their excretion."
Answered by AI
Is metolazone the same as Lasix?
"Lasix (furosemide) and Zaroxolyn (metolazone) are diuretics that are used to treat excess accumulation of fluid or swelling of the body (edema). They are also used to treat high blood pressure (hypertension)."
Answered by AI
Is metolazone a strong diuretic?
"Even at low doses, metolazone significantly increases the diuretic effects of furosemide, making it simpler to treat fluid retention. In many cases, high doses of furosemide can be avoided, which is an advantage for patients who need long-term treatment and have decreased kidney function."
Answered by AI