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What is Ramipril
RamiprilThe Generic name of this drug
Treatment SummaryRamipril is an ACE inhibitor medication that is used to treat high blood pressure, congestive heart failure, and kidney disease. It works by blocking the enzyme responsible for converting angiotensin I (ATI) to angiotensin II (ATII). ATII helps regulate blood pressure and is part of the Renin-Angiotensin-Aldosterone System (RAAS). Ramipril is also used to reduce the risk of heart attack, stroke, and death in individuals at high risk of cardiovascular events.
Altaceis the brand name
Ramipril Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Altace
Ramipril
1991
208
Approved as Treatment by the FDA
Ramipril, commonly known as Altace, is approved by the FDA for 6 uses which include High Cardiovascular Risk and Hypertensive disease .High Cardiovascular Risk
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Felodipine
Stroke
Congestive Heart Failure
Helps manage Heart Failure
Heart Attack
Helps manage Myocardial Infarction
Cardiovascular Diseases
Effectiveness
How Ramipril Affects PatientsRamipril is a type of drug that helps lower blood pressure. It does this by blocking the action of the RAAS (Renin Angiotensin Aldosterone System). This system is responsible for controlling blood pressure and fluid balance. When it is blocked, the body does not make as much aldosterone, a hormone that helps keep sodium and water in the body. It also stops the production of vasopressin and bradykinin, both of which can cause higher blood pressure. By blocking these substances, ramipril helps lower blood pressure and keep it at a healthy level.
How Ramipril works in the bodyRamipril works by blocking an enzyme in the body called ACE. This enzyme is responsible for converting one type of hormone into another that causes narrowing of blood vessels, increased inflammation, and other changes in the body. By blocking this enzyme, ramipril prevents the production of this hormone and its negative effects. At the same time, ramipril increases the production of other hormones that help widen blood vessels and reduce inflammation. It also blocks the breakdown of bradykinin, which can lead to a dry cough as a side effect.
When to interrupt dosage
The advised dosage of Ramipril is dependent upon the diagnosed condition, including Adrenal gland hypofunction, Albumin Creatinine Ratio >3mg/mmol and Heart Attack. The amount of dosage fluctuates as per the method of administration (e.g. Capsule - Oral or Tablet - Oral) highlighted in the table beneath.Condition
Dosage
Administration
Cardiovascular Events
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Adrenal gland hypofunction
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Albumin Creatinine Ratio >3mg/mmol
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Nondiabetic proteinuric chronic kidney disease
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Cardiovascular Diseases
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Congestive Heart Failure
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Albumin Creatinine Ratio >30mg/mmol
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
adequately controlled by simultaneous administration of component drugs
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Heart Attack
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Stroke
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
High Cardiovascular Risk
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Diabetic Nephropathy
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Hypertensive disease
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Warnings
Ramipril has one recognized contraindication and should not be administered in combination with the circumstances detailed in the table below.Ramipril ContraindicationsCondition
Risk Level
Notes
Type 2 Diabetes
Do Not Combine
Common Ramipril Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Ramipril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Ramipril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Ramipril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Ramipril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Ramipril.
Ramipril Toxicity & Overdose RiskOverdosing on ramipril may cause wide blood vessels, low blood pressure, slow heartbeat, and kidney failure. Liver toxicity has been reported in humans, and when the ACE inhibitor was removed, the liver enzymes decreased. No tumor-causing, genetic-altering, or fertility-impairing effects were found in animals when given doses up to 200 times the maximum recommended human exposure. The lowest toxic dose of ramipril in rats has been found to be 10g/kg, in mice 10.5g/kg, and in dogs 1g/kg.
Ramipril Novel Uses: Which Conditions Have a Clinical Trial Featuring Ramipril?
421 active clinical trials are researching the potential of Ramipril to ameliorate Adrenal gland hypofunction when administered in conjunction with other medications, as well as in reducing Cardiovascular Events.Condition
Clinical Trials
Trial Phases
Nondiabetic proteinuric chronic kidney disease
0 Actively Recruiting
High Cardiovascular Risk
1 Actively Recruiting
Phase 2
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Albumin Creatinine Ratio >30mg/mmol
0 Actively Recruiting
Congestive Heart Failure
313 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Adrenal gland hypofunction
28 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4, Phase 2
Cardiovascular Events
3 Actively Recruiting
Not Applicable
adequately controlled by simultaneous administration of component drugs
0 Actively Recruiting
Cardiovascular Diseases
0 Actively Recruiting
Heart Attack
53 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Stroke
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Albumin Creatinine Ratio >3mg/mmol
0 Actively Recruiting
Ramipril Reviews: What are patients saying about Ramipril?
5Patient Review
7/22/2015 Ramapril is really effective! I've been on it since I was 16, and now that I'm almost 20 (on 10mg dosage), the only downside is that it's caused a serious decline in my libido.
5Patient Review
6/6/2015 I've been taking 10mg for over ten years with no side effects, but my doctor says I need to take 5mg twice a day. This doesn't seem to be working as well for me. Has anyone else had similar issues?
5Patient Review
11/10/2021 This has been the best decision I've made in a while. My blood pressure is now normalized and I only had to take 2.5mg of ramipril per day. At first, I felt tired for a few weeks as my body adjusted to the medication; however, it's been great since then!
4.3Patient Review
5/31/2021 I've been taking this in 2.5mg capsule for over a year after MI. I have history of allergies to antibiotics, certain opiates and egg proteins. I have no side effects from this medication at all other than it's intended use. bp 110/70 with, 140/85 without.
3.3Patient Review
11/19/2021 Ramipril was great for reducing my blood pressure, but after a few months I started experiencing some pretty uncomfortable side effects. My doctors didn't put two and two together at first, but once I did some research on my own it was clear that the drug was to blame. Thankfully, I stopped taking it and am now waiting for a new prescription.
3.3Patient Review
10/28/2015 I've only been taking ramipril for a short while, but I have already noticed an improvement in how I feel. My blood pressure is still high, but it has come down since starting the medication. Only time will tell how well it works in the long run.
3Patient Review
2/22/2017 I unfortunately had to stop using this medication because it caused a lot of inflammation in my nose.
2.7Patient Review
7/14/2022 The dosage I was on (.75mg) caused dizziness, extreme anxiety, neck pain, and dry eyes. It's hard to tell if the benefits of having lower blood pressure are worth feeling constantly sick.
2.7Patient Review
7/2/2021 Blurred vision, memory loss, and problems with my nose, ears, and throat are just some of the issues I experienced after several years on this medication.
2.3Patient Review
5/13/2015 This medication put me in danger. I was well-controlled on Lotrel for over a decade, but my doctor switched me to Ramipril without any warning or indication that there might be problems. My blood pressure shot up with each visit, and by the fourth month I was in the emergency room. Morphine was the only thing that helped. Now I'm back on Lotrel and my BP is under control again.
2.3Patient Review
6/30/2017 I have experienced some very unpleasant side effects while taking this medication, including hot flashes and sweating. I'll be trying something else soon, as my doctor says these symptoms shouldn't be occurring.
2.3Patient Review
5/18/2017 I was on this medication for six months to help with my cough and asthma. However, after a while I realized that the medicine was actually causing me to have more coughing fits. Once I stopped taking it, the problem resolved itself.
1.7Patient Review
2/9/2016 I took this medication for ten months and it made me feel awful. I constantly had a cough, felt dizzy and nauseous, had no energy, and my anxiety grew worse. My blood pressure also got worse. Now I have protein leakage in my kidney as well.
1Patient Review
2/24/2018 About three hours after taking the medication, I had a severe allergic reaction while at work. It started with a weird feeling in my tongue and then within 60 seconds I was having trouble breathing. Fortunately, there were people around who helped me and called an ambulance. I ended up in the ER where they told me that I'm allergic to the drug. This was totally unexpected as I've never had any allergies before. If I had taken the drug 24 hours later, I would have been home alone with my 26-month-old daughter.
1Patient Review
7/22/2018 I had an incredibly negative reaction to this medication. I was vomiting, had severe diarrhea, and felt dizzy and lightheaded to the point of passing out. My blood pressure is already low, so I don't understand why my doctor prescribed this to me in the first place.
1Patient Review
8/17/2017 I was taking Ramipil for 18 months and it appeared to lower my blood pressure. However, one day I had a life-threatening anaphylactic shock while shopping. If it wasn't for the quick response of the store staff, I might not be here today.
1Patient Review
5/3/2022 I was rushed to the hospital less than three hours after taking this drug. My heart rate skyrocketed and I experienced dizziness and lapses in consciousness. Here's hoping that today will be better.
Patient Q&A Section about ramipril
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Should you take ramipril in the morning or at night?
"Your doctor may suggest that you take your first dose of ramipril before bedtime because it can dizzy. After the initial dose, you can take ramipril any time of day. Try to take it at the same each day. You can take ramipril with or without food."
Answered by AI
What are the side effects of ramipril medication?
"If you're taking ramipril and you have a cough that doesn't go away, it's likely that the medication is the cause. Cough medicines usually don't help for this kind of cough. Other common side effects of ramipril include feeling dizzy or lightheaded, especially when you stand up or sit up quickly; headaches; diarrhea; vomiting; a mild skin rash; and blurred vision."
Answered by AI
What should I avoid when taking ramipril?
"Do not use salt substitutes such as Lo-Salt while taking ramipril, as they can cause the potassium level in your blood to become too high. There are no other foods or drinks you need to avoid while taking ramipril."
Answered by AI
Does ramipril make you pee more?
"Does ramipril make you urinate frequently? No. However, using ramipril for an extended period of time can worsen kidney function. If you experience decreased frequency or amount of urine; bloody urine; increased thirst; swelling on face, fingers, or lower legs; weight gain; or increased blood pressure, tell your doctor."
Answered by AI