← Back to Search

Web-Based Lifestyle Interventions for Cancer Survivor Health (AMPLIFY Trial)

N/A

Waitlist Available

Led By Wendy Demark-Wahnefried, PhD, RD

Research Sponsored by University of Alabama at Birmingham

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Diagnosed with multiple myeloma, non-Hodgkin lymphoma, or localized kidney or ovarian cancer; or [localized (includes in situ) through regional] breast, colorectum, endometrium, thyroid, or prostate cancer.

Diagnosed with multiple myeloma, non-Hodgkin lymphoma, or localized kidney or ovarian cancer; or localized (includes in situ) through regional breast, colorectum, endometrium, thyroid, or prostate cancer

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 24 months

Awards & highlights

AMPLIFY Trial Summary

This trial will test whether web-based interventions can help cancer survivors make healthier lifestyle choices. Outcomes include things like weight management and quality of life.

Who is the study for?

This trial is for early-stage cancer survivors over 50, living in the US with a BMI of 25-50 kg/m2 and less than 150 minutes of exercise per week. They must have finished primary treatment, not be in another diet-exercise program, or have progressive/recurrent cancer. Those with severe health conditions that limit physical activity are excluded.Check my eligibility

What is being tested?

The AMPLIFI Cancer Survivor Health study tests web-based interventions to improve diet and exercise among survivors of various cancers. It aims to see if these programs can enhance physical function, muscle mass, quality of life, and overall health.See study design

What are the potential side effects?

As this trial focuses on lifestyle changes through diet and exercise interventions rather than medication, side effects may include typical exercise-related injuries or stress. Dietary changes could potentially cause digestive adjustments.

AMPLIFY Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have been diagnosed with a specific type of cancer listed.

Select...

I have been diagnosed with a specific type of cancer, including multiple myeloma, non-Hodgkin lymphoma, or localized cancer in the kidney, ovary, breast, colorectum, endometrium, thyroid, or prostate.

Select...

I am 50 years old or older.

AMPLIFY Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 24 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~24 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in body weight

Change in dietary quality and intake (Patient reported outcome).

Change in physical activity and sleep (Measured by actigraphy)

Secondary outcome measures

Change in healthcare utilization (Patient reported outcome)

Change in muscle mass (Measured by the D3 creatine dilution method)

Change in physical activity (Patient reported outcome)

+3 more

Other outcome measures

Change in CIrculating Biomarkers

Change in Comorbidity and Symptoms (Patient reported outcome)

Change in Levels of Stress (Patient reported outcome)

+5 more

AMPLIFY Trial Design

3Treatment groups

Experimental Treatment

Group I: Project 3: Combined Diet and ExerciseExperimental Treatment3 Interventions

Participants will receive the diet and exercise content simultaneously in combined web-based sessions. Participants will receive and participate in web-based sessions that focus on diet and exercise for 12 months. Participants will be encouraged to track their diet, weight and physical activity data (minutes and step counts). Tailored feedback and goal recommendations will be provided through the website. Participants will also receive access to resources for relevant behavioral topics. All participants will be invited to participate in the secret Facebook group for the project (though participation is optional).

Group II: Project 2: Exercise-DietExperimental Treatment2 Interventions

Participants will receive and participate in web-based sessions that focus on diet for 6 months, followed by exercise for another 6 months. Participants will be encouraged to track their diet and weight for the first 6 months and to log their data in the intervention website, during the second 6 months they will be asked to log their physical activity data (minutes and step counts). Tailored feedback and goal recommendations will be provided through the website. Participants will also receive access to resources for relevant behavioral topics. All participants will be invited to participate in the secret Facebook group for the project (though participation is optional).

Group III: Project 1: Diet-ExerciseExperimental Treatment2 Interventions

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor

1,584 Previous Clinical Trials

2,279,470 Total Patients Enrolled

10 Trials studying Multiple Myeloma

6,432 Patients Enrolled for Multiple Myeloma

University of TennesseeOTHER

188 Previous Clinical Trials

141,038 Total Patients Enrolled

3 Trials studying Multiple Myeloma

40 Patients Enrolled for Multiple Myeloma

National Cancer Institute (NCI)NIH

13,658 Previous Clinical Trials

40,923,886 Total Patients Enrolled

579 Trials studying Multiple Myeloma

188,528 Patients Enrolled for Multiple Myeloma

Media Library

Adapting MultiPLe Behavior Interventions That eFfectively Improve (AMPLIFI) Cancer Survivor Health Clinical Trial Eligibility Overview. Trial Name: NCT04000880 — N/A

Multiple Myeloma Research Study Groups: Project 1: Diet-Exercise, Project 3: Combined Diet and Exercise, Project 2: Exercise-Diet

Multiple Myeloma Clinical Trial 2023: Adapting MultiPLe Behavior Interventions That eFfectively Improve (AMPLIFI) Cancer Survivor Health Highlights & Side Effects. Trial Name: NCT04000880 — N/A

Adapting MultiPLe Behavior Interventions That eFfectively Improve (AMPLIFI) Cancer Survivor Health 2023 Treatment Timeline for Medical Study. Trial Name: NCT04000880 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the ultimate purpose of this investigation?

"This 30-month long study aims to measure a subject's body weight change. Secondary outcomes will include changes in waist circumference (measured with an unmarked tape placed at the umbilicus), muscle mass (assessed through ingestion of deuterium-labeled creatine and subsequent urine testing) as well as physical performance, which is tested using the Senior Fitness Battery that includes chair stands, 3m walks, 8' up and go tests, balance assessments of side-by-side, semi-tandem and tandem stances along with arm/leg stretching exercises and 2 minute step tests."

Answered by AI

Can you provide an estimate of how many individuals are participating in this experiment?

"Affirmative. According to the information provided on clinicaltrials.gov, this trial is currently recruiting participants and began its search for 652 people from two sites on March 4th 2020 with a most recent update occurring February 8th 2022."

Answered by AI

Are there any vacancies left to participate in this research project?

"Patient recruitment for this medical study is ongoing. It has been in progress since the 4th of March 2020, with its last update occurring on the 8th of February 2022."

Answered by AI