Survivorship Topics - Combined Diet and Exercise for Multiple Myeloma

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Tennessee Health Science Center, Memphis, TN
Multiple Myeloma+13 More
Survivorship Topics - Combined Diet and Exercise - Other
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether an online program can help survivors of different types of cancer improve their diet, physical activity, and weight.

See full description

Eligible Conditions

  • Multiple Myeloma
  • Non-hodgkin Lymphoma
  • Thyroid Cancers
  • Non-Hodgkin's Lymphoma (NHL)
  • Renal Cancers
  • Prostate Cancer
  • Breast Cancer
  • Colorectal Carcinoma (CRC)
  • Endometrial Cancer
  • Ovarian Cancer

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Survivorship Topics - Combined Diet and Exercise will improve 4 primary outcomes, 8 secondary outcomes, and 9 other outcomes in patients with Multiple Myeloma. Measurement will happen over the course of 24 months.

24 months
Change in CIrculating Biomarkers
Change in Comorbidity and Symptoms (Patient reported outcome)
Change in Levels of Stress (Patient reported outcome)
Change in body weight
Change in dietary quality and intake (Patient reported outcome).
Change in healthcare utilization (Patient reported outcome)
Change in muscle mass (Measured by the D3 creatine dilution method)
Change in physical activity (Patient reported outcome)
Change in physical activity and sleep (Measured by actigraphy)
Change in physical performance
Change in quality of life (Patient reported outcome)
Change in waist circumference
Health literacy and Ehealth literacy scales (eHEALS)
Health related status
PROMIS Cognitive Function + PROMIS Cognitive Abilities - 8a
Quality of Life, EQ-5D-5L
Social Support and self-efficacy for adhering to a caloric restricted diet or increased PA (Patient Reported Outcomes)
Social Support, self-efficacy and barriers for adhering to a caloric restricted diet or increased PA (Patient Reported Outcomes)
30 months
Change in body weight (Measured by study staff)
Change in physical performance (Measured by study staff)
Change in waist circumference (Measured by study staff)

Trial Safety

Safety Progress

1 of 3

Trial Design

3 Treatment Groups

Project 3: Survivorship Topics- Combined Diet and Exercise
1 of 3
Project 2: Exercise-Diet
1 of 3
Project 1: Diet-Exercise
1 of 3
Experimental Treatment

This trial requires 652 total participants across 3 different treatment groups

This trial involves 3 different treatments. Survivorship Topics - Combined Diet And Exercise is the primary treatment being studied. Participants will be divided into 3 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Project 3: Survivorship Topics- Combined Diet and ExerciseFor the first six months of the study, participants will be in the Survivorship Topics group, where they receive health information on topics other than diet and exercise. Participants will then join the intervention, receiving the diet and exercise content simultaneously in combined web-based sessions. Participants will receive and participate in web-based sessions that focus on diet and exercise for 12 months. Participants will be encouraged to track their diet, weight and physical activity data (minutes and step counts). Tailored feedback and goal recommendations will be provided through the website. Participants will also receive access to resources for relevant behavioral topics. All participants will be invited to participate in the secret Facebook group for the project (though participation is optional).
Project 2: Exercise-DietParticipants will receive and participate in web-based sessions that focus on diet for 6 months, followed by exercise for another 6 months. Participants will be encouraged to track their diet and weight for the first 6 months and to log their data in the intervention website, during the second 6 months they will be asked to log their physical activity data (minutes and step counts). Tailored feedback and goal recommendations will be provided through the website. Participants will also receive access to resources for relevant behavioral topics. All participants will be invited to participate in the secret Facebook group for the project (though participation is optional).
Project 1: Diet-ExerciseParticipants will receive and participate in web-based sessions that focus on diet for 6 months, followed by exercise for another 6 months. Participants will be encouraged to track their diet and weight for the first 6 months and to log their data in the intervention website, during the second 6 months they will be asked to log their physical activity data (minutes and step counts). Tailored feedback and goal recommendations will be provided through the website. Participants will also receive access to resources for relevant behavioral topics. All participants will be invited to participate in the secret Facebook group for the project (though participation is optional).

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 30 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 30 months for reporting.

Who is running the study

Principal Investigator
W. D.
Prof. Wendy Demark-Wahnefried, PhD
University of Alabama at Birmingham

Closest Location

University of Tennessee Health Science Center - Memphis, TN

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 10 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Age 50 years or older
Resident of the continental United States
Diagnosed with multiple myeloma, non-Hodgkin lymphoma, or localized kidney or ovarian cancer; or [localized (includes in situ) through regional] breast, colorectum, endometrium, thyroid, or prostate cancer.
Completed primary treatment (surgery, radiation or chemotherapy). Active surveillance among men with prostate cancer or women with ductal carcinoma in situ is acceptable.
Completion of the 8th grade of school. Able to read and write English.
Normal blood pressure or those with high blood pressure for whom physician permission was granted.
Community dwelling.
Reside in an area that receives wireless coverage.
Have an active email address or be willing to have one created for the study.
Current body mass index of greater than or equal to 25 kg/m2, but less than 50 kg/m2.

Patient Q&A Section

Can kidney neoplasms be cured?

"Renal cell carcinoma still is the most common malignant kidney tumor, and, although surgery is an important treatment modality, it cannot be assumed that this is a curative treatment modality in such patients. In a recent study, findings, long-term clinical outcome appeared to be good." - Anonymous Online Contributor

Unverified Answer

What causes kidney neoplasms?

"All tumors in the kidney are neoplasms (in other words, malignant disorders of the neoplasms). Primary neoplasias of the kidney can be divided into two categories: renal cortical neoplasms and kidney medullary neoplasms. Renal cortical neoplasia is a cancer of the cells that line the inner part of the kidney. Kidney medullary neoplasia is a cancer of the cells of the parts of the kidney that lie beneath or behind the kidneys' cortex. Cancer of the renal cortex is usually of one of the three types of cancer that begin in the kidneys (renal cell cancer, transitional-cell cancer, and renal pelvis carcinoma)." - Anonymous Online Contributor

Unverified Answer

What are common treatments for kidney neoplasms?

"Most of the kidney neoplasms are diagnosed as benign diseases, which can be treated by surgery. Some tumors, such as renal cell carcinoma (RCN) can be cured by surgical removal, while others, like angiomyolipoma, are curable by radiofrequency ablation (RFA), embolization or cryotherapy. Radiotherapy or surgery may also be used for some metastatic or unresectable neoplasms." - Anonymous Online Contributor

Unverified Answer

What are the signs of kidney neoplasms?

"Kidney neoplasms have many symptoms. In particular, renal tumors often cause blood in the urine, a vague costochondritic appearance, and pain in the lower back. The presence of a palpable abdominal mass, tenderness, and pain in the flank, flank, or rectum, although present in some of various pathologies of the abdomen and pelvis, points to malignancy. Lumps found in the abdomen or pelvis on ultrasonography or computed tomography (CT) scan are helpful in detecting renal tumors." - Anonymous Online Contributor

Unverified Answer

How many people get kidney neoplasms a year in the United States?

"Of patients seen in primary care in the United States, almost 8% are diagnosed with malignancies. However, kidney neoplasms are relatively rare among the general population." - Anonymous Online Contributor

Unverified Answer

What is kidney neoplasms?

"Results from a recent paper highlights the fact that neoplasia, most commonly kidney cancer, is a significant cause of morbidity and mortality in patients with severe CKD. Neoplasms may be detected long before CKD with imaging, and these images are often used for follow-up and to monitor patients who are on dialysis." - Anonymous Online Contributor

Unverified Answer

What does survivorship topics - combined diet and exercise usually treat?

"Although patients who do not receive any treatment still experience [pain] and discomfort from these diseases after treatment, patients who receive treatment have better survivorship than non-treated patients." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of survivorship topics - combined diet and exercise?

"The common side effects of survivorship topics are common. These effects are not unique to D&E but appear to be also common with normal survivorship-oriented diet and exercise programs. The D&E approach should not be viewed as safe because its risk for some of these common side effects is not clear." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in survivorship topics - combined diet and exercise for therapeutic use?

"This review highlights survivorship topics in kidney cancer, colorectal cancer, and cervical cancer. This information will be of value to patients and clinicians and may be useful in patient care decision-making to facilitate self-monitoring and self-management strategies." - Anonymous Online Contributor

Unverified Answer

Does kidney neoplasms run in families?

"The occurrence of childhood nephropathy and an increased frequency of renal abnormalities in family members suggest that nephropathy and renal abnormalities may be hereditary in certain families and are indicative of a genetic predispositions. However, an increased number of family members with a history of hypertension or kidney cancer suggests the possibility that these traits are environmental." - Anonymous Online Contributor

Unverified Answer

How quickly does kidney neoplasms spread?

"Despite their early diagnosis and aggressive treatment, the disease progresses and becomes life-threatening in most patients. Results from a recent paper suggests that the clinical course of kidney tumour patients is variable. Results from a recent paper may improve the quality of treatment of kidney tumours, to improve the prognosis. More prospective studies are needed to establish the natural evolution of kidney tumour disease." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of kidney neoplasms?

"The authors identified patient disease characteristics that have previously been associated with kidney neoplasms and show that the vast majority of neoplasms are of clear cell histology. Their findings also may help clinicians anticipate the most likely indications for kidney biopsy." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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