This trial is evaluating whether Benzoyl peroxide gel will improve 1 primary outcome in patients with Arthrosis. Measurement will happen over the course of Tissues samples taken at the time of surgery will be held for 14 days.
This trial requires 496 total participants across 2 different treatment groups
This trial involves 2 different treatments. Benzoyl Peroxide Gel is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 4 and have been shown to be safe and effective in humans.
"Arthrosis is a non-specific word meaning “jointed and united body” in Greek. It is usually used to describe both diseases and deformities which affect joints. Some examples are gout, rheumatoid arthritis and osteoarthritis. All of them are joint disorders resulting from cartilage damage, inflammation and/or hyperplasia of the subchondral bone, synovial membrane and/or joint space. If the cartilage defect is confined to a joint space, cartilage in the joint will heal and this results in the formation of a hardened hardened (or calcified) area around the joint." - Anonymous Online Contributor
"A systematic rehabilitation program significantly reduced joint inflammation, improved joint alignment, and improved patients' function compared with usual care and no treatment. Results from a recent paper are based on objective measurements with special attention to change in pain, change in joint alignment, change in range of motion, change in activity, and change in self-reported functional status." - Anonymous Online Contributor
"Arthrosis occurs in some 10% of middle-aged and older adults over a five-year time period. There is a graded increase in the prevalence of arthrosis with increasing age. The risk of arthrosis is lower in women than in men. Arthrosis has an impacts heavily on the quality of life and mobility.\n\n- Arthrosis at WebMD\n- "
"Hans Schönfeld\n\nHans Schönfeld (14 January 1882 in Reichenwalde - 3 December 1941 in Berlin) was a German entomologist who worked on the Coleoptera and Hymenoptera." - Anonymous Online Contributor
"Arthrosis has multiple signs. For example, arthrosis can make pain worse; it can reduce range of motion; and it can restrict joint function. Arthrosis can make a person feel less enthusiastic about pursuing activities, and can affect quality of life. Arthrosis can cause pain, and can affect physical fitness and physical function." - Anonymous Online Contributor
"This review provides an overview of available treatments of arthrosis. The treatments are broadly similar to those recommended for [osteoarthritis](https://www.withpower.com/clinical-trials/osteoarthritis). However, this review is mainly limited to the knee, and evidence for alternatives to conservative treatment could be reviewed, considering also other joints. A systematic review comparing conservative versus alternative treatment programs is needed for treatment of other types of arthritis." - Anonymous Online Contributor
"There are several factors that place people at risk for arthrosis. It can be predicted based upon genetic factors because it is closely related to osteoporosis. On the other hand, exercise is crucial to halting and reversing joint damage as well as reducing degeneration in the joints. Thus, it is important for people to keep a healthy weight, exercise regularly and keep on exercising properly according to the age of the individual. It is suggested that men of all ages need at least 1 hour of exercise per day to keep the joints active. In addition to physical activity, it is suggested that a healthy diet is important for preventing or preventing arthritis or slowing the progress of arthritis in the knee of both sexes." - Anonymous Online Contributor
"In a recent study, findings demonstrates a high incidence of common applicationsite side effects associated with the use of BPO. There is a need for studies to identify the effective usage of BPO and the avoidance of side effects in the treatment of acne vulgaris." - Anonymous Online Contributor
"Arthritis is a heterogeneous condition, and specific drugs approved for prevention or treatment of arthritis do not work for all patients. As a result, clinical trials for arthritis are urgently needed. The NIDAAmesse guideline on arthritis recommends that clinical trials should use treatment responders as their target population. Power-based clinical trials are available in your local area for specific indications, such as arthritis of the knee, hand, or lower back." - Anonymous Online Contributor
"There are indications that benzoyl peroxide gel does not increase scar formation and reduces discomfort related to the application of a postoperative dressing and is also less irritating in the area of use." - Anonymous Online Contributor
"Arthrosis is the most common chronic disease in our country and is usually found in people between the ages of 60 and 70 years. In Finland, the age of onset of arthrosis in women is around 65-70 years and in men the age of onset is around 70-75 years. The age of onset is more similar to that in Germany than to those found in other Nordic countries." - Anonymous Online Contributor
"The benzoyl peroxide gel application was well tolerated with improvement in physical limitations, self-efficacy and total physical function in patients with mild-to-moderate chronic, progressive and debilitating arthrosis, when compared with placebo and was significantly more effective than placebo at improving the overall physical functioning questionnaire." - Anonymous Online Contributor
"Serious adverse events can arise during the follow-up period for all patients in the Arthrosis®-trial, especially in the subgroup of patients with more severe disease. The development rates of a new fracture have to be investigated, as well as the course as well as the exact outcome of all events." - Anonymous Online Contributor