Benzoyl peroxide gel for Arthrosis

Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Colorado Joint Replacement, Denver, CO
Arthrosis+1 More
Benzoyl peroxide gel - Drug
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This study is evaluating whether a particular type of bacteria can be found on the skin of people who have had hip surgery.

See full description

Eligible Conditions

  • Arthrosis
  • Osteoarthritis, Degenerative

Treatment Effectiveness

Effectiveness Progress

3 of 3
This is further along than 93% of similar trials

Study Objectives

This trial is evaluating whether Benzoyl peroxide gel will improve 1 primary outcome in patients with Arthrosis. Measurement will happen over the course of Tissues samples taken at the time of surgery will be held for 14 days.

Day 14
Propionibacterium colinization rate on hips of healthy subjects

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Side Effects for

Benzoyl Peroxide Gel + Tazarotene
Upper respiratory tract infection
5%
Epistaxis
3%
Nasopharyngitis
3%
Application site irritation
3%
Application site erythema
2%
Sinusitis
2%
Application site pain
2%
Infectious mononucleosis
1%
Headache
1%
Ear infection
1%
Urinary tract infection
1%
Seasonal allergy
1%
Application site burn
1%
Insomnia
1%
Pharyngitis
1%
Furuncle
1%
Cough
1%
Pharyngolaryngeal pain
1%
Hypotension
1%
Gastroenteritis
1%
Application site exfoliation
1%
Application site dryness
1%
Multiple allergies
1%
Lyme disease
1%
Excoriation
1%
Dermatitis
1%
Pyrexia
0%
Pain
0%
Vaginitis bacterial
0%
Sinus congestion
0%
Fibromatosis
0%
Menorrhagia
0%
Rhinorrhoea
0%
Tooth impacted
0%
Pharyngitis streptococcal
0%
Dehydration
0%
Oral herpes
0%
Viral infection
0%
Tinea pedis
0%
Viral pharyngitis
0%
Muscle strain
0%
Procedural pain
0%
Bronchitis
0%
Food allergy
0%
Localised infection
0%
Vomiting
0%
Facial bones fracture
0%
Erythema
0%
Joint injury
0%
Skin exfoliation
0%
Application site dermatitis
0%
Cellulitis
0%
Influenza
0%
Tonsillitis
0%
Contusion
0%
Sunburn
0%
Arthralgia
0%
Back pain
0%
Ovarian cyst
0%
Nasal congestion
0%
Wisdom teeth removal
0%
Dyspepsia
0%
Conjunctivitis
0%
Aphthous stomatitis
0%
Lip blister
0%
Nausea
0%
Cyst
0%
Application site pruritus
0%
Local swelling
0%
Application site discolouration
0%
Gastroenteritis viral
0%
Condition aggravated
0%
Allergy to arthropod bite
0%
Allergy to metals
0%
Herpes simplex
0%
Joint sprain
0%
Hordeolum
0%
Rash generalised
0%
Skin irritation
0%
Smear cervix abnormal
0%
Dermatitis atopic
0%
Dry skin
0%
This histogram enumerates side effects from a completed 2009 Phase 2 trial (NCT00713609) in the Benzoyl Peroxide Gel + Tazarotene ARM group. Side effects include: Upper respiratory tract infection with 5%, Epistaxis with 3%, Nasopharyngitis with 3%, Application site irritation with 3%, Application site erythema with 2%.

Trial Design

2 Treatment Groups

Standard Skin Prep
1 of 2
Experimental Skin Prep with BPO
1 of 2
Active Control
Experimental Treatment

This trial requires 496 total participants across 2 different treatment groups

This trial involves 2 different treatments. Benzoyl Peroxide Gel is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 4 and have been shown to be safe and effective in humans.

Experimental Skin Prep with BPO
Drug
Patients will undergo a skin cleansing protocols using 4% Chlorhexidine gluconate (CHG) cloths. Following the CHG wipes, patients will be prepped with 5% BPO gel applied directly to the biopsy site. After the skin prep, three 3-mm punch (Acu-Punch, Acuderm, Fort Lauderdale, FL) skin biopsies will performed for both an anterior-based hypothetical incision, and for a more lateral/posterior incision, for a total of 6 biopsies taken per subject.
Standard Skin PrepPatients will undergo a skin cleansing protocols using 4% Chlorhexidine gluconate (CHG) cloths. After the skin prep, three 3-mm punch (Acu-Punch, Acuderm, Fort Lauderdale, FL) skin biopsies will performed for both an anterior-based hypothetical incision, and for a more lateral/posterior incision, for a total of 6 biopsies taken per subject.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Benzoyl peroxide
FDA approved

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: tissues samples taken at the time of surgery will be held for 14 days
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly tissues samples taken at the time of surgery will be held for 14 days for reporting.

Closest Location

Colorado Joint Replacement - Denver, CO

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Patients who are 18 to 79 85 years of age
CJR primary joint arthroplasty patients who are receiving care at Porter Adventist Hospital
CJR established primary knee or hip arthroplasty patients with a native hip joint (no replacement on the biopsy side) who volunteers as a research participant.
CJR patients without a previous arthroplasty procedure who have established care with our practice.

Patient Q&A Section

What is arthrosis?

"Arthrosis is a non-specific word meaning “jointed and united body” in Greek. It is usually used to describe both diseases and deformities which affect joints. Some examples are gout, rheumatoid arthritis and osteoarthritis. All of them are joint disorders resulting from cartilage damage, inflammation and/or hyperplasia of the subchondral bone, synovial membrane and/or joint space. If the cartilage defect is confined to a joint space, cartilage in the joint will heal and this results in the formation of a hardened hardened (or calcified) area around the joint." - Anonymous Online Contributor

Unverified Answer

Can arthrosis be cured?

"A systematic rehabilitation program significantly reduced joint inflammation, improved joint alignment, and improved patients' function compared with usual care and no treatment. Results from a recent paper are based on objective measurements with special attention to change in pain, change in joint alignment, change in range of motion, change in activity, and change in self-reported functional status." - Anonymous Online Contributor

Unverified Answer

How many people get arthrosis a year in the United States?

"Arthrosis occurs in some 10% of middle-aged and older adults over a five-year time period. There is a graded increase in the prevalence of arthrosis with increasing age. The risk of arthrosis is lower in women than in men. Arthrosis has an impacts heavily on the quality of life and mobility.\n\n- Arthrosis at WebMD\n- "

"Hans Schönfeld\n\nHans Schönfeld (14 January 1882 in Reichenwalde - 3 December 1941 in Berlin) was a German entomologist who worked on the Coleoptera and Hymenoptera." - Anonymous Online Contributor

Unverified Answer

What are the signs of arthrosis?

"Arthrosis has multiple signs. For example, arthrosis can make pain worse; it can reduce range of motion; and it can restrict joint function. Arthrosis can make a person feel less enthusiastic about pursuing activities, and can affect quality of life. Arthrosis can cause pain, and can affect physical fitness and physical function." - Anonymous Online Contributor

Unverified Answer

What are common treatments for arthrosis?

"This review provides an overview of available treatments of arthrosis. The treatments are broadly similar to those recommended for [osteoarthritis](https://www.withpower.com/clinical-trials/osteoarthritis). However, this review is mainly limited to the knee, and evidence for alternatives to conservative treatment could be reviewed, considering also other joints. A systematic review comparing conservative versus alternative treatment programs is needed for treatment of other types of arthritis." - Anonymous Online Contributor

Unverified Answer

What causes arthrosis?

"There are several factors that place people at risk for arthrosis. It can be predicted based upon genetic factors because it is closely related to osteoporosis. On the other hand, exercise is crucial to halting and reversing joint damage as well as reducing degeneration in the joints. Thus, it is important for people to keep a healthy weight, exercise regularly and keep on exercising properly according to the age of the individual. It is suggested that men of all ages need at least 1 hour of exercise per day to keep the joints active. In addition to physical activity, it is suggested that a healthy diet is important for preventing or preventing arthritis or slowing the progress of arthritis in the knee of both sexes." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of benzoyl peroxide gel?

"In a recent study, findings demonstrates a high incidence of common applicationsite side effects associated with the use of BPO. There is a need for studies to identify the effective usage of BPO and the avoidance of side effects in the treatment of acne vulgaris." - Anonymous Online Contributor

Unverified Answer

Who should consider clinical trials for arthrosis?

"Arthritis is a heterogeneous condition, and specific drugs approved for prevention or treatment of arthritis do not work for all patients. As a result, clinical trials for arthritis are urgently needed. The NIDAAmesse guideline on arthritis recommends that clinical trials should use treatment responders as their target population. Power-based clinical trials are available in your local area for specific indications, such as arthritis of the knee, hand, or lower back." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in benzoyl peroxide gel for therapeutic use?

"There are indications that benzoyl peroxide gel does not increase scar formation and reduces discomfort related to the application of a postoperative dressing and is also less irritating in the area of use." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets arthrosis?

"Arthrosis is the most common chronic disease in our country and is usually found in people between the ages of 60 and 70 years. In Finland, the age of onset of arthrosis in women is around 65-70 years and in men the age of onset is around 70-75 years. The age of onset is more similar to that in Germany than to those found in other Nordic countries." - Anonymous Online Contributor

Unverified Answer

Does benzoyl peroxide gel improve quality of life for those with arthrosis?

"The benzoyl peroxide gel application was well tolerated with improvement in physical limitations, self-efficacy and total physical function in patients with mild-to-moderate chronic, progressive and debilitating arthrosis, when compared with placebo and was significantly more effective than placebo at improving the overall physical functioning questionnaire." - Anonymous Online Contributor

Unverified Answer

How serious can arthrosis be?

"Serious adverse events can arise during the follow-up period for all patients in the Arthrosis®-trial, especially in the subgroup of patients with more severe disease. The development rates of a new fracture have to be investigated, as well as the course as well as the exact outcome of all events." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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