Sodium Nitroprusside

Hypertensive crisis, Patients Undergoing Surgery, Intraoperative Blood Loss + 2 more
Treatment
7 Active Studies for Sodium Nitroprusside

What is Sodium Nitroprusside

NitroprussideThe Generic name of this drug
Treatment SummaryNitroprusside is a drug used to widen blood vessels and lower blood pressure in patients with hypertensive emergencies. It is administered intravenously and works by supplying nitric oxide to the body, which relaxes the walls of both arteries and veins.
Nitropressis the brand name
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Sodium Nitroprusside Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nitropress
Nitroprusside
2005
30

Effectiveness

How Sodium Nitroprusside Affects PatientsNitroprusside is a drug that relaxes the walls of blood vessels, especially veins, causing them to expand and increasing blood flow. It does not have an effect on other muscle groups, such as the uterus or duodenum.
How Sodium Nitroprusside works in the bodySodium nitroprusside works in two ways. First, it breaks down into molecules that bind to hemoglobin, forming a compound called cyanmethemoglobin. This compound binds to cyanide ions, which are toxic, and removes them from the body. Second, it breaks down further into nitric oxide, which increases production of a molecule called cGMP. This molecule helps reduce calcium in the cells, leading to relaxation of the blood vessels and a widening of the arteries.

When to interrupt dosage

The amount of Sodium Nitroprusside is contingent upon the determined condition, including induction of Intraoperative Hypotension, Hypertensive crisis and Intraoperative Blood Loss. The measure of dosage is subject to the method of delivery noted in the table beneath.
Condition
Dosage
Administration
Hypertensive crisis
, 50.0 mg/mL, 50.0 mg, 25.0 mg/mL, 0.5 mg/mL, 0.2 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous
Patients Undergoing Surgery
, 50.0 mg/mL, 50.0 mg, 25.0 mg/mL, 0.5 mg/mL, 0.2 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous
induction of Intraoperative Hypotension
, 50.0 mg/mL, 50.0 mg, 25.0 mg/mL, 0.5 mg/mL, 0.2 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous
Intraoperative Blood Loss
, 50.0 mg/mL, 50.0 mg, 25.0 mg/mL, 0.5 mg/mL, 0.2 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous
Acute Heart Failure (AHF)
, 50.0 mg/mL, 50.0 mg, 25.0 mg/mL, 0.5 mg/mL, 0.2 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous

Warnings

Sodium Nitroprusside Contraindications
Condition
Risk Level
Notes
compensatory hypertension
Do Not Combine
tobacco ambylopia
Do Not Combine
Operative Surgery
Do Not Combine
Emergency Surgery
Do Not Combine
Optic Atrophy
Do Not Combine
Pulmonary Vascular Resistance
Do Not Combine
There are 20 known major drug interactions with Sodium Nitroprusside.
Common Sodium Nitroprusside Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Nitroprusside may increase the hypotensive activities of Amifostine.
Technetium Tc-99m oxidronate
Major
Nitroprusside can cause a decrease in the absorption of Technetium Tc-99m oxidronate resulting in a reduced serum concentration and potentially a decrease in efficacy.
3-Aza-2,3-Dihydrogeranyl Diphosphate
Minor
Nitroprusside can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Abacavir
Minor
Nitroprusside may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acebutolol
Minor
Nitroprusside may increase the hypotensive activities of Acebutolol.
Sodium Nitroprusside Toxicity & Overdose RiskTaking too much nitroprusside can cause dangerously low blood pressure, cyanide poisoning, or thiocyanate poisoning. The lethal dose in rabbits, dogs, mice, and rats is 2.8, 5.0, 8.4, and 11.2 mg/kg respectively.
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Sodium Nitroprusside Novel Uses: Which Conditions Have a Clinical Trial Featuring Sodium Nitroprusside?

There are 7 active studies examining the potential of Sodium Nitroprusside to address Hypertensive crisis, Acute Heart Failure (AHF) and induce Intraoperative Hypotension for therapeutic purposes.
Condition
Clinical Trials
Trial Phases
Acute Heart Failure (AHF)
4 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 3
Intraoperative Blood Loss
3 Actively Recruiting
Not Applicable, Phase 3
Hypertensive crisis
0 Actively Recruiting
Patients Undergoing Surgery
0 Actively Recruiting
induction of Intraoperative Hypotension
0 Actively Recruiting

Sodium Nitroprusside Reviews: What are patients saying about Sodium Nitroprusside?

3.7Patient Review
12/24/2007
Sodium Nitroprusside for Severe Uncontrolled High Blood Pressure
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Patient Q&A Section about sodium nitroprusside

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What class of drug is sodium nitroprusside?

"Nitropress is a vasodilator, a class of drug that relaxes blood vessels."

Answered by AI

What is the action of nitroprusside?

"Nitroprusside dilates blood vessels and is used to treat hypertension, reduce postoperative bleeding, and manage acute heart failure."

Answered by AI

What is sodium nitroprusside used for?

"Sodium nitroprusside injection can lower blood pressure immediately in adults and children with high blood pressure. It can also reduce bleeding during surgery and treat acute heart failure."

Answered by AI

What is formula of sodium nitroprusside?

"Sodium nitroprusside is a chemical compound with the formula C5H4FeN6Na2O3. It is a reddish-brown solid that is soluble in water and is used as a reagent in various chemical reactions."

Answered by AI

Clinical Trials for Sodium Nitroprusside

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