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Diuretic Therapy for Heart Failure (ESCALATE Trial)
ESCALATE Trial Summary
This trial is testing a new way to give diuretics to people with heart failure in the emergency room, using less medication while still keeping sodium levels low.
ESCALATE Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowESCALATE Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.ESCALATE Trial Design
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- You have very low or high levels of certain minerals in your blood that haven't been treated.I am scheduled to receive IV diuretics during my first day in the hospital.The doctor thinks you have more than 10 pounds of extra fluid in your body, or you have a previous weight that the doctor knows you should be at.I was diagnosed with Acute Heart Failure in the Emergency Department.I am older than 18 years.I have symptoms or test results that suggest acute heart failure.I am not taking medications that can harm my hearing.This criterion means that any of the following conditions will be considered for exclusion.I am listed for a heart transplant or have a ventricular assist device.Your blood pressure is less than 90 mmHg when you give your permission to participate.I have a severe heart valve problem or cardiomyopathy.I have swelling in my legs.I need a tube inserted to help me breathe right away.I have had symptoms of a heart attack with changes in my ECG.Your body temperature is higher than 100.5 degrees Fahrenheit.I am on dialysis for end-stage kidney disease.I've received more than 2 IV diuretic doses since being admitted to the hospital.You have swelling in the veins in your neck.
- Group 1: Protocolized spot urine sodium guided diuretic therapy
- Group 2: Guideline-based care
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is enrollment still available for this trial?
"Affirmative. According to the information listed on clinicaltrials.gov, this medical trial is currently recruiting patients and was originally posted in May 1st 2022. The study seeks 484 participants from 2 sites as of its last update on 5/23/2022."
How hazardous is Protocolized spot urine sodium guided diuretic therapy to individuals?
"This Phase 2 trial has provided some evidence of safety, resulting in Protocolized spot urine sodium guided diuretic therapy receiving a score of two. However, there is not yet any data demonstrating efficacy."
What is the maximum capacity of participants for this investigation?
"Affirmative, the available information on clinicaltrials.gov denotes that this research endeavour is actively seeking participants. It was first published on May 1st 2022 and underwent revisions as recently as 23rd of the same month. At present, 484 candidates are needed at 2 sites for enrolment."
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What site did they apply to?
What portion of applicants met pre-screening criteria?
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