Amrix

Chronic Pain, Physical Therapy, Rest + 2 more
Treatment
20 Active Studies for Amrix

What is Amrix

CyclobenzaprineThe Generic name of this drug
Treatment SummaryCyclobenzaprine is a muscle relaxant first developed in 1961 that became available for human use in 1977. It is similar to an antidepressant medication, but it differs by one double bond. This drug is used as a short-term treatment for muscle spasms related to injuries.
Flexerilis the brand name
image of different drug pills on a surface
Amrix Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Flexeril
Cyclobenzaprine
1977
498

Effectiveness

How Amrix Affects PatientsCyclobenzaprine is a medication used to relax tight muscles and reduce spasms. It works in the brainstem area, but how it works is not yet understood. Its effects usually last 4-6 hours, but it stays in the body longer, with a long half-life. Taking cyclobenzaprine with other serotonin-affecting medications can lead to a condition called serotonin syndrome, which can cause changes in mental status, muscle issues, and other symptoms. If any of these reactions occur, cyclobenzaprine should be stopped right away.
How Amrix works in the bodyWe don't know exactly how cyclobenzaprine works, but it appears to act on the brainstem. This helps reduce the activity of certain neurons, which then decreases the amount of nerve signals sent out to muscles. It may also work by blocking the serotonin pathway in the spinal cord, which is related to transmitting signals from the brain to the body.

When to interrupt dosage

The advised dosage of Amrix is contingent upon the diagnosed condition, for example Physical Therapy, Rest and Chronic Pain. The dosage amount also relies upon the prescribed method of administration listed in the table beneath.
Condition
Dosage
Administration
Chronic Pain
, 10.0 mg, 5.0 mg, 7.5 mg, 15.0 mg, 30.0 mg, 0.1 mg, 1.0 mg/mg, 2.5 mg/mg, 5.6 mg/mg, 2.8 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release - Oral, Capsule, extended release, Kit, Kit - Oral, Topical, Kit - Topical, Capsule, film coated, extended release, Capsule, film coated, extended release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Oral; Topical, Kit - Oral; Topical
Physical Therapy
, 10.0 mg, 5.0 mg, 7.5 mg, 15.0 mg, 30.0 mg, 0.1 mg, 1.0 mg/mg, 2.5 mg/mg, 5.6 mg/mg, 2.8 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release - Oral, Capsule, extended release, Kit, Kit - Oral, Topical, Kit - Topical, Capsule, film coated, extended release, Capsule, film coated, extended release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Oral; Topical, Kit - Oral; Topical
Spasm
, 10.0 mg, 5.0 mg, 7.5 mg, 15.0 mg, 30.0 mg, 0.1 mg, 1.0 mg/mg, 2.5 mg/mg, 5.6 mg/mg, 2.8 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release - Oral, Capsule, extended release, Kit, Kit - Oral, Topical, Kit - Topical, Capsule, film coated, extended release, Capsule, film coated, extended release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Oral; Topical, Kit - Oral; Topical
Rest
, 10.0 mg, 5.0 mg, 7.5 mg, 15.0 mg, 30.0 mg, 0.1 mg, 1.0 mg/mg, 2.5 mg/mg, 5.6 mg/mg, 2.8 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release - Oral, Capsule, extended release, Kit, Kit - Oral, Topical, Kit - Topical, Capsule, film coated, extended release, Capsule, film coated, extended release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Oral; Topical, Kit - Oral; Topical
acute painful musculoskeletal conditions
, 10.0 mg, 5.0 mg, 7.5 mg, 15.0 mg, 30.0 mg, 0.1 mg, 1.0 mg/mg, 2.5 mg/mg, 5.6 mg/mg, 2.8 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release - Oral, Capsule, extended release, Kit, Kit - Oral, Topical, Kit - Topical, Capsule, film coated, extended release, Capsule, film coated, extended release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Oral; Topical, Kit - Oral; Topical

Warnings

Amrix Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Heart Block
Do Not Combine
Hyperthyroidism
Do Not Combine
Atrial Fibrillation
Do Not Combine
Heart Block
Do Not Combine
Myocardial Infarction
Do Not Combine
Congestive Heart Failure
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Cyclobenzaprine may interact with Pulse Frequency
There are 20 known major drug interactions with Amrix.
Common Amrix Drug Interactions
Drug Name
Risk Level
Description
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
Cyclobenzaprine may increase the serotonergic activities of 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Azelastine
Major
Cyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Benmoxin
Major
Cyclobenzaprine may increase the serotonergic activities of Benmoxin.
Brofaromine
Major
Cyclobenzaprine may increase the serotonergic activities of Brofaromine.
Caroxazone
Major
Cyclobenzaprine may increase the serotonergic activities of Caroxazone.
Amrix Toxicity & Overdose RiskThe toxic dose of cyclobenzaprine in mice and rats is 338 mg/kg and 425 mg/kg respectively. Symptoms of overdose can include extreme sleepiness, rapid heartbeat, shaking, confusion, and hallucinations. In rare cases, the overdose can cause cardiac arrest, abnormal heart rhythm, dangerously low blood pressure, seizures, or a severe reaction of the nervous system. If someone has overdosed on cyclobenzaprine, it is recommended to call a poison control center before attempting to treat them. Treatment usually involves removing the drug from the body, closely monitoring their heart rate, and checking for signs of decreased breathing or a low
image of a doctor in a lab doing drug, clinical research

Amrix Novel Uses: Which Conditions Have a Clinical Trial Featuring Amrix?

179 active clinical trials are being conducted to evaluate the efficacy of Amrix in providing relief from Muscle Spasms, Physical Therapy and Restorative Rest.
Condition
Clinical Trials
Trial Phases
Rest
0 Actively Recruiting
Spasm
0 Actively Recruiting
acute painful musculoskeletal conditions
0 Actively Recruiting
Chronic Pain
129 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 3, Early Phase 1, Phase 1
Physical Therapy
6 Actively Recruiting
Not Applicable

Amrix Reviews: What are patients saying about Amrix?

5Patient Review
9/20/2013
Amrix for Muscle Spasm
This drug has helped me immensely. I used to suffer from daily spasms, but this medication has all but stopped them. It's also much easier to tolerate than the last one I was on; that one had way too many side effects for me to handle.
5Patient Review
6/24/2014
Amrix for Disorder characterized by Stiff, Tender & Painful Muscles
This is the first medication I've tried for my si joint dysfunction that has actually made a significant difference. I don't experience any grogginess, just less pain.
5Patient Review
12/4/2013
Amrix for Muscle Spasm
This medication has been a game-changer for me. I have MS and it's the first afternoon drug that doesn't make me drowsy but still relieves my spasms.
4.7Patient Review
5/19/2014
Amrix for Disorder characterized by Stiff, Tender & Painful Muscles
I was very surprised at how well this worked, especially given the high price tag. I would definitely recommend it to anyone who needs relief from muscle pain.
4.7Patient Review
8/17/2013
Amrix for Disorder characterized by Stiff, Tender & Painful Muscles
This treatment has made life worth living again.
4.7Patient Review
12/18/2011
Amrix for Muscle Spasm
4.7Patient Review
5/3/2012
Amrix for Muscle Spasm
4Patient Review
12/26/2015
Amrix for Muscle Spasm
I've been dealing with some pretty severe chronic pain in my upper back for a while now, and I've tried lots of different treatments. Finally, I found something that works: Amrix (brand name Prolax ER 15/30mg). It's helped me sleep better and the pain is gone. The only downside is that it gives me a sore throat, but overall it's a great medication.
3.3Patient Review
4/1/2013
Amrix for Muscle Spasm
This medication helped with my coughing and breathing, but I found it difficult to take as directed.
3Patient Review
4/2/2013
Amrix for Disorder characterized by Stiff, Tender & Painful Muscles
The medication does its job well enough, but it's certainly not extraordinary. The real issue I have with it is the cost; even with good insurance, I'm still paying $75 per prescription. That's just too expensive for me, so I'll be looking for a cheaper alternative.
1.7Patient Review
1/3/2014
Amrix for Disorder characterized by Stiff, Tender & Painful Muscles
I just started this medicine, and I wanted to know about the potential side effects before taking it.
1Patient Review
1/9/2012
Amrix for Disorder characterized by Stiff, Tender & Painful Muscles
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about amrix

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does cyclobenzaprine do to your body?

"Cyclobenzaprine is used to relax muscles, relieve pain, stiffness, and discomfort caused by strains, sprains, or injuries."

Answered by AI

Is Amrix the same as Flexeril?

"Amrix and Flexeril are both brand-name medications that contain the active drug cyclobenzaprine. Flexeril has been discontinued and is no longer available. Amrix is a long-acting form of cyclobenzaprine that comes in an extended-release (ER) capsule. It is taken by mouth once a day."

Answered by AI

Is Amrix a benzo?

"Some common benzodiazepines are diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan), temazepam (Restoril), and clonazepam (Klonopin). Cyclobenzaprine is also known by the brand names Flexeril and Amrix."

Answered by AI

What is the drug Amrix used for?

"Cyclobenzaprine is a medication used to treat muscle spasms. It is typically used in conjunction with rest and physical therapy. The medication works by helping to relax the muscles. Cyclobenzaprine is not recommended for use in older adults due to an increased risk of side effects."

Answered by AI

Clinical Trials for Amrix

Image of Vanderbilt University Medical Center in Nashville, United States.

Lidocaine Infusions for Postoperative Pain

18+
All Sexes
Nashville, TN
The goal of this single-center, pragmatic, randomized, blinded, placebo-controlled trial is to evaluate the impact of intravenous (IV) lidocaine within the existing Enhanced Recovery After Surgery (ERAS)program on outcomes in patients after major abdominal surgery. The main questions the trial aims to answer are: The primary hypothesis is that utilization of IV lidocaine as part of a perioperative multimodal pain regimen will result in a reduction in hospital Case Mix Index-Adjusted Resource Length of Stay (CARLOS). The secondary hypotheses are that lidocaine infusion will result in a reduction in total inpatient opioid consumption (oral morphine milligram equivalents, oMMEs) and pain scores, and improved surgical outcomes (including return of bowel function, ileus, nausea, rapid responses called, surgical site infections, and ICU transfers), while also having minimal incidence of side effects (including double/blurry vision, tinnitus, sedation, and adverse events requiring early cessation).
Phase 4
Waitlist Available
Vanderbilt University Medical CenterDanial Shams, MD
Image of Baylor College of Medicine/Texas Children's Hospital in Austin, United States.

Guided Imagery Therapy for Abdominal Pain

7 - 12
All Sexes
Austin, TX
Chronic abdominal pain is common among children, and the majority of cases are attributed to functional abdominal pain disorders. One approach to treating these disorders is by using psychological therapies. This clinical trial aims to see how well pre-recorded guided imagery therapy sessions help children's abdominal pain when delivered via a mobile application (app) on a smartphone or tablet. Participants will complete a baseline abdominal pain and stooling diary to determine eligibility, as well as other surveys. Eligible participants will be given access to the guided imagery therapy mobile application. This intervention asks participants to listen to a 10- to 15-minute GIT session 5 out of 7 days per week for 8 weeks, in addition to their usual care for their abdominal pain. Then, participants will complete another abdominal pain and stooling diary, along with other psychometric surveys, at the end of this intervention period. Participants will also collect another diary and surveys 3 months post-treatment.
Waitlist Available
Has No Placebo
Baylor College of Medicine/Texas Children's Hospital (+1 Sites)
Have you considered Amrix clinical trials? We made a collection of clinical trials featuring Amrix, we think they might fit your search criteria.Go to Trials
Image of University Hospitals Cleveland Medical Center in Cleveland, United States.

Erector Spinae Plane Block for Pain

21 - 75
All Sexes
Cleveland, OH
As per usual care for spine surgery, participants will have their back cleaned with alcohol and a needle will be placed using ultrasound for the ESP block. Through the needle, a small catheter will be placed in the participants back and the needle removed. Approximately one hour prior to the start of surgery, a numbing medication (ropivacaine, similar to Novocaine) in combination with dexmedetomidine (a pain medicine that is used in nerve block and that is not a narcotic) and contrast dye (iohexol) will be injected through the catheter. Participants will then go through the QST procedure (test of buzzing sensation and temperature sensation through pads applied to their skin) to assess the numb areas and then head to the operating room. In the operating room, the catheter will be removed after the surgeon obtains baseline CT scan images of the spine. Once surgery is completed, investigators will record pain scores over the next four days in the hospital and the amount of pain medication needed for controlling pain related to the surgery.
Recruiting
Has No Placebo
University Hospitals Cleveland Medical CenterSalim Hayek, MD
Have you considered Amrix clinical trials? We made a collection of clinical trials featuring Amrix, we think they might fit your search criteria.Go to Trials
Image of BC Children's Hospital in Vancouver, Canada.

Digital Media for Anxiety in Children

5 - 23
All Sexes
Vancouver, Canada
The goal of this clinical trial is to learn whether different forms of media (2D, 360, or 360 in virtual reality) have different impacts on pre-procedural anxiety and post-procedural pain in children. The main questions it aims to answer are: Does one type (and richness) of media reduce pre-procedural anxiety and post-procedural pain more than another type of media? For example, will learning about an upcoming procedure by watching a 360 video in virtual reality reduce pre-procedural anxiety more than learning about the same upcoming procedure by watching it in a 2D video or 360 video? The second question is whether watching a 360 video in VR about an upcoming procedure more effective in reducing pre-procedural anxiety and post-procedural pain compared to the 2D video or the 360 video without VR groups for specific procedures? For example, is watching an explanation of a procedure in VR always more effective in reducing pre-procedural anxiety and post-procedural pain, or is it procedure specific (i.e., watching a video about surgery preparation is more effective in VR, but for cast removal it doesn't matter whether participants learn about their procedure viewed through VR, 360 video, or 2D)?
Recruiting
Has No Placebo
BC Children's Hospital
Image of Active Aging Research Team, Robert H. N. Ho Research Centre in Vancouver, Canada.

Choose to Move Replacement Ready for Osteoarthritis

18+
All Sexes
Vancouver, Canada
Choose to Move (CTM) is a 3-month, choice-based health-promoting program for low active older adults being scaled-up across British Columbia (BC), Canada. Recently, the investigators adapted CTM for the \>14000 people in BC who are on surgical waitlists for total knee replacement or total hip replacement (TKR/THR) for osteoarthritis (OA). The primary goal of this observational study is to learn if the adapted program, Choose to Move Replacement Ready (CTM-RR), is feasible to deliver to people with hip and/or knee osteoarthritis who are on surgical waitlists for TKR/THR. Participants who enrol in CTM-RR will answer online survey questions about the program and about their physical activity, mobility, pain, function, quality of life, willingness to undergo surgery, overall perception of their joint condition, psychosocial health, self-efficacy, social isolation, loneliness, and sedentary time. CTM-RR activity coaches will also answer online survey questions about the program. CTM-RR participants, activity coaches, and referral partners will also participate in interviews about the program.
Recruiting
Has No Placebo
Active Aging Research Team, Robert H. N. Ho Research CentreHeather A. McKay, PhD
Image of Manitoba Men's Health Clinic in Winnipeg, Canada.

Virtual Reality for Pain and Anxiety

18+
Male
Winnipeg, Canada
The goal of this clinical trial is to learn if a virtual reality (VR) program (TRIPP) can reduce pain, anxiety, and distress in adult men (aged 18+) undergoing a vasectomy under local anesthesia. The main questions it aims to answer are: * Does using VR during a vasectomy lower patients' pain during the procedure compared to standard care? * Does VR reduce anxiety and distress compared to standard care? * Are patients more satisfied with their experience when using VR compared to standard care? Researchers will compare two groups: * VR group: Patients will use a VR headset with a guided meditation program (TRIPP) during their vasectomy. * Control group: Patients will receive standard care (no VR). Participants will: * Be randomly assigned to either the VR group or control group. * Complete brief questionnaires before, during, and after the procedure (about 15-20 minutes each time). * (VR group only) Use a VR headset during the procedure and provide optional feedback about the experience. Why is this important? Vasectomies are typically done with local anesthesia (pain relief), but many patients still feel anxiety or discomfort. VR may help distract and relax patients, improving their experience. This study will help health professionals understand if VR could be a useful option for future patients.
Waitlist Available
Has No Placebo
Manitoba Men's Health ClinicRenée El-Gabalawy, MA, PhD, C. Psych
Have you considered Amrix clinical trials? We made a collection of clinical trials featuring Amrix, we think they might fit your search criteria.Go to Trials
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