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What is Amrix
CyclobenzaprineThe Generic name of this drug
Treatment SummaryCyclobenzaprine is a muscle relaxant first developed in 1961 that became available for human use in 1977. It is similar to an antidepressant medication, but it differs by one double bond. This drug is used as a short-term treatment for muscle spasms related to injuries.
Flexerilis the brand name
Amrix Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Flexeril
Cyclobenzaprine
1977
498
Effectiveness
How Amrix Affects PatientsCyclobenzaprine is a medication used to relax tight muscles and reduce spasms. It works in the brainstem area, but how it works is not yet understood. Its effects usually last 4-6 hours, but it stays in the body longer, with a long half-life. Taking cyclobenzaprine with other serotonin-affecting medications can lead to a condition called serotonin syndrome, which can cause changes in mental status, muscle issues, and other symptoms. If any of these reactions occur, cyclobenzaprine should be stopped right away.
How Amrix works in the bodyWe don't know exactly how cyclobenzaprine works, but it appears to act on the brainstem. This helps reduce the activity of certain neurons, which then decreases the amount of nerve signals sent out to muscles. It may also work by blocking the serotonin pathway in the spinal cord, which is related to transmitting signals from the brain to the body.
When to interrupt dosage
The advised dosage of Amrix is contingent upon the diagnosed condition, for example Physical Therapy, Rest and Chronic Pain. The dosage amount also relies upon the prescribed method of administration listed in the table beneath.Condition
Dosage
Administration
Physical Therapy
, 10.0 mg, 5.0 mg, 7.5 mg, 15.0 mg, 30.0 mg, 0.1 mg, 1.0 mg/mg, 2.5 mg/mg, 5.6 mg/mg, 2.8 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release - Oral, Capsule, extended release, Kit, Kit - Oral, Topical, Kit - Topical, Capsule, film coated, extended release, Capsule, film coated, extended release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Oral; Topical, Kit - Oral; Topical
acute painful musculoskeletal conditions
, 10.0 mg, 5.0 mg, 7.5 mg, 15.0 mg, 30.0 mg, 0.1 mg, 1.0 mg/mg, 2.5 mg/mg, 5.6 mg/mg, 2.8 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release - Oral, Capsule, extended release, Kit, Kit - Oral, Topical, Kit - Topical, Capsule, film coated, extended release, Capsule, film coated, extended release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Oral; Topical, Kit - Oral; Topical
Chronic Pain
, 10.0 mg, 5.0 mg, 7.5 mg, 15.0 mg, 30.0 mg, 0.1 mg, 1.0 mg/mg, 2.5 mg/mg, 5.6 mg/mg, 2.8 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release - Oral, Capsule, extended release, Kit, Kit - Oral, Topical, Kit - Topical, Capsule, film coated, extended release, Capsule, film coated, extended release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Oral; Topical, Kit - Oral; Topical
Rest
, 10.0 mg, 5.0 mg, 7.5 mg, 15.0 mg, 30.0 mg, 0.1 mg, 1.0 mg/mg, 2.5 mg/mg, 5.6 mg/mg, 2.8 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release - Oral, Capsule, extended release, Kit, Kit - Oral, Topical, Kit - Topical, Capsule, film coated, extended release, Capsule, film coated, extended release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Oral; Topical, Kit - Oral; Topical
Muscle Spasms
, 10.0 mg, 5.0 mg, 7.5 mg, 15.0 mg, 30.0 mg, 0.1 mg, 1.0 mg/mg, 2.5 mg/mg, 5.6 mg/mg, 2.8 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release - Oral, Capsule, extended release, Kit, Kit - Oral, Topical, Kit - Topical, Capsule, film coated, extended release, Capsule, film coated, extended release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Oral; Topical, Kit - Oral; Topical
Warnings
Amrix ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Heart Block
Do Not Combine
Hyperthyroidism
Do Not Combine
Atrial Fibrillation
Do Not Combine
Conduction Disturbances
Do Not Combine
Myocardial Infarction
Do Not Combine
Congestive Heart Failure
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Cyclobenzaprine may interact with Pulse Frequency
Common Amrix Drug Interactions
Drug Name
Risk Level
Description
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
Cyclobenzaprine may increase the serotonergic activities of 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Azelastine
Major
Cyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Benmoxin
Major
Cyclobenzaprine may increase the serotonergic activities of Benmoxin.
Brofaromine
Major
Cyclobenzaprine may increase the serotonergic activities of Brofaromine.
Caroxazone
Major
Cyclobenzaprine may increase the serotonergic activities of Caroxazone.
Amrix Toxicity & Overdose RiskThe toxic dose of cyclobenzaprine in mice and rats is 338 mg/kg and 425 mg/kg respectively. Symptoms of overdose can include extreme sleepiness, rapid heartbeat, shaking, confusion, and hallucinations. In rare cases, the overdose can cause cardiac arrest, abnormal heart rhythm, dangerously low blood pressure, seizures, or a severe reaction of the nervous system. If someone has overdosed on cyclobenzaprine, it is recommended to call a poison control center before attempting to treat them. Treatment usually involves removing the drug from the body, closely monitoring their heart rate, and checking for signs of decreased breathing or a low
Amrix Novel Uses: Which Conditions Have a Clinical Trial Featuring Amrix?
179 active clinical trials are being conducted to evaluate the efficacy of Amrix in providing relief from Muscle Spasms, Physical Therapy and Restorative Rest.Condition
Clinical Trials
Trial Phases
Rest
0 Actively Recruiting
Muscle Spasms
0 Actively Recruiting
Chronic Pain
175 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Physical Therapy
7 Actively Recruiting
Not Applicable
acute painful musculoskeletal conditions
0 Actively Recruiting
Amrix Reviews: What are patients saying about Amrix?
5Patient Review
9/20/2013 This drug has helped me immensely. I used to suffer from daily spasms, but this medication has all but stopped them. It's also much easier to tolerate than the last one I was on; that one had way too many side effects for me to handle.
5Patient Review
6/24/2014 This is the first medication I've tried for my si joint dysfunction that has actually made a significant difference. I don't experience any grogginess, just less pain.
5Patient Review
12/4/2013 This medication has been a game-changer for me. I have MS and it's the first afternoon drug that doesn't make me drowsy but still relieves my spasms.
4.7Patient Review
5/19/2014 I was very surprised at how well this worked, especially given the high price tag. I would definitely recommend it to anyone who needs relief from muscle pain.
4.7Patient Review
8/17/2013 This treatment has made life worth living again.
4.7Patient Review
12/18/20114.7Patient Review
5/3/20124Patient Review
12/26/2015 I've been dealing with some pretty severe chronic pain in my upper back for a while now, and I've tried lots of different treatments. Finally, I found something that works: Amrix (brand name Prolax ER 15/30mg). It's helped me sleep better and the pain is gone. The only downside is that it gives me a sore throat, but overall it's a great medication.
3.3Patient Review
4/1/2013 This medication helped with my coughing and breathing, but I found it difficult to take as directed.
3Patient Review
4/2/2013 The medication does its job well enough, but it's certainly not extraordinary. The real issue I have with it is the cost; even with good insurance, I'm still paying $75 per prescription. That's just too expensive for me, so I'll be looking for a cheaper alternative.
1.7Patient Review
1/3/2014 I just started this medicine, and I wanted to know about the potential side effects before taking it.
1Patient Review
1/9/2012Patient Q&A Section about amrix
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does cyclobenzaprine do to your body?
"Cyclobenzaprine is used to relax muscles, relieve pain, stiffness, and discomfort caused by strains, sprains, or injuries."
Answered by AI
Is Amrix the same as Flexeril?
"Amrix and Flexeril are both brand-name medications that contain the active drug cyclobenzaprine. Flexeril has been discontinued and is no longer available. Amrix is a long-acting form of cyclobenzaprine that comes in an extended-release (ER) capsule. It is taken by mouth once a day."
Answered by AI
Is Amrix a benzo?
"Some common benzodiazepines are diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan), temazepam (Restoril), and clonazepam (Klonopin). Cyclobenzaprine is also known by the brand names Flexeril and Amrix."
Answered by AI
What is the drug Amrix used for?
"Cyclobenzaprine is a medication used to treat muscle spasms. It is typically used in conjunction with rest and physical therapy. The medication works by helping to relax the muscles. Cyclobenzaprine is not recommended for use in older adults due to an increased risk of side effects."
Answered by AI