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What is Viread
Tenofovir disoproxilThe Generic name of this drug
Treatment SummaryTenofovir disoproxil fumarate is an antiviral medication used to treat HIV and Hepatitis B. It is sold under the brand name Viread and is part of a class of drugs called nucleotide analogue reverse transcriptase inhibitors (nRTIs). This drug is usually prescribed in combination with other medications. It was approved by the FDA in 2001.
Vireadis the brand name
Viread Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Viread
Tenofovir disoproxil
2001
154
Effectiveness
How Viread Affects PatientsTenofovir is an antiviral medicine used to treat HIV-1 and Hepatitis B infections. Lab tests show that it works by stopping the virus from making copies of itself. It was found to be effective with a concentration of 0.04 to 8.5 micrometers. Taking tenofovir with other antiviral medications has been shown to have an additional or synergistic effect in preventing the virus from replicating. Tenofovir has been approved by the FDA to treat HIV-1.
How Viread works in the bodyTenofovir is a medication used to treat HIV. It works by blocking an enzyme that helps the virus replicate, limiting its spread and allowing the virus to be managed. Tenofovir is absorbed in the body and converted to its active form, tenofovir diphosphate. This active form competes with natural deoxyribonucleotide substrate for binding to HIV-1 reverse transcriptase and hepatitis B polymerase, which then stops the virus from copying itself. In rare cases, HIV-1 may develop a resistance to tenofovir, meaning the virus can still replicate even with treatment.
When to interrupt dosage
The proposed measure of Viread is contingent upon the diagnosed ailment, like Anti-Retroviral Agents, High Risk Patients and Chronic Hepatitis B. The quantity of dosage is contingent upon the technique of delivery (e.g. Tablet or Tablet, film coated) cited in the following table.Condition
Dosage
Administration
HIV-1 RNA Less Than or Equal to 100,000 copies/mL
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
Antiretroviral Therapy
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
HIV
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
HIV
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
Chronic Hepatitis B Infection
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
virologically-suppressed
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
Obesity
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
Obesity
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
Warnings
There are 20 known major drug interactions with Viread.Common Viread Drug Interactions
Drug Name
Risk Level
Description
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Tenofovir disoproxil is combined with Neomycin.
Tenofovir
Major
Tenofovir disoproxil may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Tenofovir disoproxil may increase the nephrotoxic activities of Tenofovir alafenamide.
Abacavir
Minor
Tenofovir disoproxil may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acetaminophen
Minor
Tenofovir disoproxil may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
Viread Toxicity & Overdose RiskBreastfeeding: The Centers for Disease Control and Prevention recommend that HIV-1-infected mothers not breast-feed while taking tenofovir disoproxil. Carcinogenesis: Long-term studies in mice and rats found no evidence of cancer at doses up to 16 and 5 times the recommended human dose, respectively. However, female mice had an increase in liver adenomas at a higher dose. Pregnancy: Tenofovir disoproxil has been assigned to pregnancy Category B. Animal studies have found no harm to the fetus, but there are no adequate studies
Viread Novel Uses: Which Conditions Have a Clinical Trial Featuring Viread?
46 active trials are presently being conducted to assess Viread for its potential to substitute existing antiretroviral regimens for virologically suppressed (HIV1 RNA <50 copies/mL) adult patients on a stable regimen at the commencement of therapy, as well as for Chronic Hepatitis B and HIV (Human Immunodeficiency Virus) treatment.Condition
Clinical Trials
Trial Phases
Antiretroviral Therapy
1 Actively Recruiting
Phase 2
Obesity
0 Actively Recruiting
HIV-1 RNA Less Than or Equal to 100,000 copies/mL
0 Actively Recruiting
HIV
38 Actively Recruiting
Phase 2, Phase 3, Early Phase 1, Not Applicable, Phase 1, Phase 4
virologically-suppressed
0 Actively Recruiting
Chronic Hepatitis B Infection
6 Actively Recruiting
Phase 3, Phase 2
HIV
0 Actively Recruiting
Obesity
0 Actively Recruiting
Viread Reviews: What are patients saying about Viread?
5Patient Review
11/18/2012 Viread is much easier to take than Intron A, however I have experienced some negative side effects such as poor appetite and constant joint popping. Additionally, I am concerned about the lack of information available regarding pregnancy while taking this medication.
5Patient Review
4/28/2012 I've only been taking this medication for a month, and I seem to catch colds really easily. Can I take a liver care alternative medication at the same time? I have also stabilized my sorrosis and gotten rid of my rashes.
5Patient Review
11/9/2015 I was positive for Chronic Hbv in 1990 and started a double-blind study for a new drug. I ended up being given Hepsera, but my viral load skyrocketed after the completion of the study. I started taking Viread and lamivudine, then switched to Viread 300mg and Baraclude (1mg, then .5mg). My viral load has been undetectable and my liver tests have been somewhat normal for over 7 years.
5Patient Review
1/8/2015 I've been feeling really terrible lately and my blood tests aren't improving. I'm considering quitting this treatment, but I don't know if the benefits will outweigh the bad side effects.
5Patient Review
4/24/2014 Though I experienced some daily side effects, such as a low-grade fever, body aches, dizziness, nausea, headaches, and nightmares, this treatment was ultimately effective.
Patient Q&A Section about viread
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the generic name for Viread?
"Tenofovir is available as a generic and brand-name drug. The brand names for tenofovir are Viread and Vemlidy. Tenofovir comes in two forms: an oral tablet and an oral powder. The oral tablet form of tenofovir is approved to treat both HIV infection and chronic hepatitis b virus infection."
Answered by AI
What is Viread used for?
"Viread is a drug used to treat HIV and hepatitis b. It is taken in combination with other antiretroviral drugs. Viread is used to treat HIV-1 infection in adults and children aged 12 and over. It is also used to treat chronic hepatitis B."
Answered by AI
How long do you take Viread?
"You will usually need to take tenofovir for the rest of your life, even if you are feeling well. This is to keep your immune system healthy."
Answered by AI
Is Viread the same as Truvada?
"Viread is one medication in a pill that also includes another HIV medication called Emtriva. This pill is called Truvada. Viread is also part of other combination pills that are taken in one dose. These are for treatment of HIV and are called Single-dose treatment regimens (STRs). Atripla is one such pill that includes Viread as well as two other medications, TDF and Sustiva."
Answered by AI
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