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What is Viread
Tenofovir disoproxilThe Generic name of this drug
Treatment SummaryTenofovir disoproxil fumarate is an antiviral medication used to treat HIV and Hepatitis B. It is sold under the brand name Viread and is part of a class of drugs called nucleotide analogue reverse transcriptase inhibitors (nRTIs). This drug is usually prescribed in combination with other medications. It was approved by the FDA in 2001.
Vireadis the brand name
Viread Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Viread
Tenofovir disoproxil
2001
154
Effectiveness
How Viread Affects PatientsTenofovir is an antiviral medicine used to treat HIV-1 and Hepatitis B infections. Lab tests show that it works by stopping the virus from making copies of itself. It was found to be effective with a concentration of 0.04 to 8.5 micrometers. Taking tenofovir with other antiviral medications has been shown to have an additional or synergistic effect in preventing the virus from replicating. Tenofovir has been approved by the FDA to treat HIV-1.
How Viread works in the bodyTenofovir is a medication used to treat HIV. It works by blocking an enzyme that helps the virus replicate, limiting its spread and allowing the virus to be managed. Tenofovir is absorbed in the body and converted to its active form, tenofovir diphosphate. This active form competes with natural deoxyribonucleotide substrate for binding to HIV-1 reverse transcriptase and hepatitis B polymerase, which then stops the virus from copying itself. In rare cases, HIV-1 may develop a resistance to tenofovir, meaning the virus can still replicate even with treatment.
When to interrupt dosage
The proposed measure of Viread is contingent upon the diagnosed ailment, like Anti-Retroviral Agents, High Risk Patients and Chronic Hepatitis B. The quantity of dosage is contingent upon the technique of delivery (e.g. Tablet or Tablet, film coated) cited in the following table.Condition
Dosage
Administration
HIV
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
HIV
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
Chronic Hepatitis B Infection
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
virologically-suppressed
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
weight at least 35 kg
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
weigh >40 kg
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
HIV-1 RNA Less Than or Equal to 100,000 copies/mL
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
Antiretroviral Therapy
300.0 mg, , 245.0 mg, 150.0 mg, 200.0 mg, 250.0 mg, 0.04 mg/mg, 0.033 mg/mg, 123.0 mg, 163.0 mg, 204.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Granule, Granule - Oral
Warnings
There are 20 known major drug interactions with Viread.Common Viread Drug Interactions
Drug Name
Risk Level
Description
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Tenofovir disoproxil is combined with Neomycin.
Tenofovir
Major
Tenofovir disoproxil may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Tenofovir disoproxil may increase the nephrotoxic activities of Tenofovir alafenamide.
Abacavir
Minor
Tenofovir disoproxil may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acetaminophen
Minor
Tenofovir disoproxil may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
Viread Toxicity & Overdose RiskBreastfeeding: The Centers for Disease Control and Prevention recommend that HIV-1-infected mothers not breast-feed while taking tenofovir disoproxil. Carcinogenesis: Long-term studies in mice and rats found no evidence of cancer at doses up to 16 and 5 times the recommended human dose, respectively. However, female mice had an increase in liver adenomas at a higher dose. Pregnancy: Tenofovir disoproxil has been assigned to pregnancy Category B. Animal studies have found no harm to the fetus, but there are no adequate studies
Viread Novel Uses: Which Conditions Have a Clinical Trial Featuring Viread?
46 active trials are presently being conducted to assess Viread for its potential to substitute existing antiretroviral regimens for virologically suppressed (HIV1 RNA <50 copies/mL) adult patients on a stable regimen at the commencement of therapy, as well as for Chronic Hepatitis B and HIV (Human Immunodeficiency Virus) treatment.Condition
Clinical Trials
Trial Phases
Antiretroviral Therapy
2 Actively Recruiting
Phase 3, Phase 1
HIV
0 Actively Recruiting
virologically-suppressed
0 Actively Recruiting
weight at least 35 kg
0 Actively Recruiting
HIV
42 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
weigh >40 kg
0 Actively Recruiting
HIV-1 RNA Less Than or Equal to 100,000 copies/mL
0 Actively Recruiting
Chronic Hepatitis B Infection
7 Actively Recruiting
Phase 3, Phase 2, Phase 1
Viread Reviews: What are patients saying about Viread?
5Patient Review
11/18/2012 Viread is much easier to take than Intron A, however I have experienced some negative side effects such as poor appetite and constant joint popping. Additionally, I am concerned about the lack of information available regarding pregnancy while taking this medication.
5Patient Review
4/28/2012 I've only been taking this medication for a month, and I seem to catch colds really easily. Can I take a liver care alternative medication at the same time? I have also stabilized my sorrosis and gotten rid of my rashes.
5Patient Review
11/9/2015 I was positive for Chronic Hbv in 1990 and started a double-blind study for a new drug. I ended up being given Hepsera, but my viral load skyrocketed after the completion of the study. I started taking Viread and lamivudine, then switched to Viread 300mg and Baraclude (1mg, then .5mg). My viral load has been undetectable and my liver tests have been somewhat normal for over 7 years.
5Patient Review
1/8/2015 I've been feeling really terrible lately and my blood tests aren't improving. I'm considering quitting this treatment, but I don't know if the benefits will outweigh the bad side effects.
5Patient Review
4/24/2014 Though I experienced some daily side effects, such as a low-grade fever, body aches, dizziness, nausea, headaches, and nightmares, this treatment was ultimately effective.
5Patient Review
2/16/2015 No unpleasant side effects that I've noticed. In just three months, the treatment was undetectable in my system. The only downside is a dull pain on my right side occasionally.
5Patient Review
2/20/2015 I have chronic hepatitis B and have been taking this medication for over a year. My viral load has gone from 2 million to undetectable. I haven't experienced any negative side effects, but my vitamin D levels are on the low end of normal. So, I'm taking D to get the level up. There is also evidence that good levels of D can help prevent melanoma, which I recently had. Overall, I'm very pleased with the results except for the effect on my wallet!
5Patient Review
5/16/20085Patient Review
7/15/20084.7Patient Review
9/5/2015 I've been taking this medication for over five years and it's been great. My only complaint is that it sometimes makes me itch, but other than that I haven't had any issues.
4.3Patient Review
10/23/2009 I've been on Viread for a little over five years now, and it's working well for me in combination with Ziagen and Sustiva. The side effects are tolerable; I have mild lipodystrophy around my waist, high triglycerides, low good cholesterol, and high bad cholesterol. However, being undetectible is more important to me.
4.3Patient Review
4/2/2017 I've been using this medication for two years and it's done wonders for my health. That said, I am now experiencing extreme thirst, bone pain, weakness, and shortness of breath. I'm not sure if skipping a day here or there would help, but I definitely feel like my bones aren't as strong as they used to be.
4.3Patient Review
2/9/2014 I've been taking Viread for a year now and it's working great. I'm undetectable. But I'm wondering what will happen if I stop taking the medication or how long I have to take it for. My doctor says I have to take it for the rest of my life, but is that really true?
4.3Patient Review
2/3/20084Patient Review
4/22/2014 I've been taking this drug for a little over two months. I started experiencing some vomiting and nausea, but it's manageable. It can be hard to fall asleep sometimes, but I'm still active with sports. So far the viral count has dropped from 14million to 163IU/mL, which is good progress.
4Patient Review
6/22/2013 I've been taking Viread for two years and it's done a great job controlling the virus with relatively few side effects. The only issues I have are cold hands/feet, weird dreams, and occasional trouble sleeping; however, these are manageable.
4Patient Review
10/9/2014 I've been taking Viread 300mg daily since my liver transplant in 2010. I had chronic Hep B which turned into cancer, but this medication has helped me a lot. The only downside is some occasional heart palpitations, cold hands/feet, and diarrhea.
3.7Patient Review
3/28/2012 The medication is effective, but there are some drawbacks.
3.3Patient Review
3/31/2009Patient Q&A Section about viread
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the generic name for Viread?
"Tenofovir is available as a generic and brand-name drug. The brand names for tenofovir are Viread and Vemlidy. Tenofovir comes in two forms: an oral tablet and an oral powder. The oral tablet form of tenofovir is approved to treat both HIV infection and chronic hepatitis b virus infection."
Answered by AI
What is Viread used for?
"Viread is a drug used to treat HIV and hepatitis b. It is taken in combination with other antiretroviral drugs. Viread is used to treat HIV-1 infection in adults and children aged 12 and over. It is also used to treat chronic hepatitis B."
Answered by AI
How long do you take Viread?
"You will usually need to take tenofovir for the rest of your life, even if you are feeling well. This is to keep your immune system healthy."
Answered by AI
Is Viread the same as Truvada?
"Viread is one medication in a pill that also includes another HIV medication called Emtriva. This pill is called Truvada. Viread is also part of other combination pills that are taken in one dose. These are for treatment of HIV and are called Single-dose treatment regimens (STRs). Atripla is one such pill that includes Viread as well as two other medications, TDF and Sustiva."
Answered by AI