Zerit

HIV
Treatment
1 FDA approval
20 Active Studies for Zerit

What is Zerit

StavudineThe Generic name of this drug
Treatment SummaryZidovudine is a medication used to treat HIV. It works by blocking the virus’s ability to make copies of itself, slowing down the spread of the infection.
Zeritis the brand name
image of different drug pills on a surface
Zerit Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zerit
Stavudine
1994
45

Approved as Treatment by the FDA

Stavudine, commonly known as Zerit, is approved by the FDA for 1 uses including HIV .
HIV
Used in combination with Stavudine to help manage Human Immunodeficiency Virus (HIV) Infections

Effectiveness

How Zerit Affects PatientsStavudine is a medication used to fight HIV-1. It works by blocking the HIV reverse transcriptase enzyme, which stops the virus from making copies of itself. Stavudine is turned into an active form in the body, which then interferes with the process of building new DNA for the virus. This prevents the virus from growing, as it needs this DNA to make copies of itself.
How Zerit works in the bodyStavudine works to stop HIV-1 from replicating. It does this by blocking reverse transcriptase, an enzyme that helps HIV-1 reproduce, from using its natural substrate, dGTP, and by preventing the incorporation of Stavudine into viral DNA.

When to interrupt dosage

The prescribed dosage of Zerit is contingent upon the diagnosed affliction. The measure of dosage is contingent upon the method of delivery (e.g. Oral or Capsule, gelatin coated - Oral) featured in the table beneath.
Condition
Dosage
Administration
HIV
15.0 mg, , 20.0 mg, 30.0 mg, 40.0 mg, 1.0 mg/mL, 200.0 mg, 100.0 mg, 75.0 mg, 37.5 mg, 50.0 mg
, Powder, for solution - Oral, Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Powder, for solution, Capsule, Capsule - Oral, Solution, Solution - Oral, For solution - Oral, For solution, Capsule, extended release, Capsule, extended release - Oral

Warnings

There are 20 known major drug interactions with Zerit.
Common Zerit Drug Interactions
Drug Name
Risk Level
Description
Acepromazine
Minor
Stavudine may increase the neurotoxic activities of Acepromazine.
Aceprometazine
Minor
Stavudine may increase the neurotoxic activities of Aceprometazine.
Acetophenazine
Minor
Stavudine may increase the neurotoxic activities of Acetophenazine.
Alimemazine
Minor
Stavudine may increase the neurotoxic activities of Alimemazine.
Amineptine
Minor
Stavudine may increase the neurotoxic activities of Amineptine.
Zerit Toxicity & Overdose RiskTaking too much stavudine (ZERIT) can lead to tingling, burning, numbness, or pain in the hands or feet, a potentially fatal build-up of acid in the blood, an enlarged and inflamed liver, and even liver failure.
image of a doctor in a lab doing drug, clinical research

Zerit Novel Uses: Which Conditions Have a Clinical Trial Featuring Zerit?

122 active clinical trials are in progress to evaluate the potential of Zerit for managing HIV infection.
Condition
Clinical Trials
Trial Phases
HIV
157 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable, Phase 4, Early Phase 1

Zerit Reviews: What are patients saying about Zerit?

4Patient Review
7/3/2011
Zerit for HIV
I've been on this medication for over two decades now and I'm starting to experience some side effects, like lower back pain and abdominal pain. Not sure if it's the Zerit or just age, but I might need to switch drugs soon.
1.7Patient Review
3/15/2010
Zerit for HIV
This medication has caused facial disfigurement on both sides of my face.
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Patient Q&A Section about zerit

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is another name for stavudine?

"Stavudine (d4T) is an antiretroviral medication that is used to prevent and treat HIV/AIDS. It is generally recommended to be used with other antiretrovirals."

Answered by AI

What are the side effects of stavudine?

"You may experience weakness, numbness, tingling, or burning pain in your hands or feet, nausea, vomiting, diarrhea, rash, or headache."

Answered by AI

Is Zerit still available?

"There are no brand or generic versions of stavudine available in the U.S."

Answered by AI

What is Zerit used for?

"ZERIT can be used in combination with other drugs to treat HIV-1 infection."

Answered by AI

Clinical Trials for Zerit

Image of University of Alabama at Birmingham in Birmingham, United States.

Olfactory Training for HIV

18+
All Sexes
Birmingham, AL
The goal of this study is to examine two types of olfactory interventions (olfactory training vs overnight odor diffuser) in adults with HIV. The two research questions are: 1. Determine if participants find the intervention acceptable and assess feasibility of the study. 2. Determine if the intervention improves olfactory function and cognitive function. Participants will come to our office and be administered the baseline battery of questions including olfactory and cognitive performance tests. Then they will be randomized and sent home with one of the two interventions (below) in which they will engage in it for 8 weeks, after which they come back to our office for the posttest battery of questions including olfactory and cognitive performance test. 1. Olfactory Training at Home -- 4 scents in which they will smell twice a day for 8 weeks. 2. Overnight Diffuser Group -- a single scent diffuser that participants will turn on while they sleep and use for 8 weeks.
Phase < 1
Waitlist Available
University of Alabama at Birmingham
Image of Los Angeles General Medical Center in Los Angeles, United States.

Decision Support Tool for HIV Treatment

18+
All Sexes
Los Angeles, CA
This study is testing software designed to help healthcare providers choose the best HIV treatment combinations for their patients. HIV medicines, known as antiretroviral therapy (ART), can be complex to manage because the right regimen depends on many factors-such as drug resistance, other health conditions, and medication schedules. Many people with HIV are cared for by general clinicians who may not have access to HIV specialists, which can make treatment decisions more challenging. In this study, healthcare providers will use patient cases to compare standard HIV treatment resources with a new clinical decision support tool that gives evidence-based ART recommendations at the point of care. The investigators hypothesize that using the tool will help providers select treatment plans that better match clinical guidelines, make decisions faster, reduce mental effort, and increase overall satisfaction with the prescribing process.
Waitlist Available
Has No Placebo
Los Angeles General Medical CenterHayoun Lee, PhD
Image of University of North Carolina in Chapel Hill, United States.

MGD020 + MGD014 for HIV

18 - 65
All Sexes
Chapel Hill, NC
This research study aims to find out how safe and well tolerated the experimental study drugs are when given to persons with HIV (PWH) taking antiretroviral therapy (ART). The study treatments are MGD014 and MGD020, which are two antibodies developed specifically for HIV, and Vorinostat, an oral medication to help expose HIV in cells to the antibodies. The study will measure the impact of study treatment on non-active HIV in cells, and how long MGD014 and MGD020 stay in the body after they are given. In this study, participants will be randomly assigned to one of three groups. All participants receive MGD014 and MGD020, given sequentially as infusions through an IV for 4 doses. Participants in one group (group A) receive only MGD014 and MGD020. Participants in another group (group B) will stop taking their ART therapy for up to 8 weeks (a temporary treatment interruption (TTI)) while receiving MGD014 and MGD020. Participants in the third group (group C) receive Vorinostat in addition to MGD014 and MGD020. Total time of participation is about 8 months and involves 13 or 18 visits, depending on group assignment.
Phase 1
Recruiting
University of North CarolinaCynthia L. Gay, MD
Have you considered Zerit clinical trials? We made a collection of clinical trials featuring Zerit, we think they might fit your search criteria.Go to Trials
Have you considered Zerit clinical trials? We made a collection of clinical trials featuring Zerit, we think they might fit your search criteria.Go to Trials
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N-803 for HIV

18 - 70
All Sexes
San Francisco, CA
Even though HIV medicine stops the virus from making more copies of itself, the virus remains in the body by hiding inside of immune cells. This hidden virus is referred to as the "latent reservoir." Researchers on this team are studying whether stimulating the immune system can change the nature of the latent reservoir and if this could help people control HIV without the need to take regular HIV medicine. This study is testing a drug called N-803. N-803 is also known as Interleukin-15 or "IL-15", a powerful and long lasting protein that can affect the immune system by stimulating immune cells such as CD8+ T cells and natural killer (NK) cells. CD8+ T cells and NK cells are both crucial for eliminating infected cells. The drug is FDA-approved for the treatment of bladder cancer, but in this study the drug is being used experimentally for HIV.
Phase 2
Waitlist Available
UCSF
Image of Alabama CRS (Site ID: 31788) in Birmingham, United States.

Dasatinib + Quercetin for HIV

18+
All Sexes
Birmingham, AL
This clinical trial is a Phase II study designed to test the safety and effectiveness of a combination of dasatinib and quercetin (D+Q) in improving physical function for people with HIV who are frail or prefrail. The study will involve 80 participants, all aged 50 or older, who have been living with HIV for at least 10 years determined to meet criteria for diagnosis of frail or prefrail and are currently on a stable antiretroviral therapy with viral suppression. Participants will be randomly assigned to one of two groups: one group will receive the D+Q treatment, and the other will receive a placebo. The treatment will be given in six cycles over 12 weeks, with participants taking the medication for two days followed by 12 days without treatment. After the 12-week treatment period, participants will be monitored for another 12 weeks to assess the long-term effects. The study aims to determine if D+Q can improve physical function and other health outcomes in this population. Randomization will be stratified by sex and age to ensure balanced groups.
Phase 2
Waitlist Available
Alabama CRS (Site ID: 31788) (+26 Sites)
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DynamiCare + Patient Navigation for Stimulant Use Disorder

18+
All Sexes
New Haven, CT
Justice-involved individuals face disproportionately high rates of stimulant use disorder and HIV, along with disrupted access to HIV treatment and prevention services like ART and PrEP. Contingency management (CM) is the most effective intervention for stimulant use, but its use in justice-involved populations has been limited by logistical and structural barriers. DynamiCare is an FDA-approved mobile app that delivers behavioral CM and has shown promise in reducing stimulant use, but its impact on HIV-related outcomes remains unknown. The RESTORE study (Recovery and Engagement for Stimulant Users on Re-entry) will evaluate whether combining DynamiCare with patient navigation (DynamiCare-plus) improves PrEP/ART initiation and reduces stimulant use among individuals recently released from justice settings. The R61 phase will assess feasibility, acceptability, and preliminary effectiveness among 40 participants. If milestones are met, the R33 phase will scale to a randomized controlled trial with 252 participants to assess effectiveness, implementation, and cost. This scalable, mobile approach has the potential to address a critical gap in care for a highly vulnerable population.
Waitlist Available
Has No Placebo
Yale University (+1 Sites)Ank Nijhawan, MD
Have you considered Zerit clinical trials? We made a collection of clinical trials featuring Zerit, we think they might fit your search criteria.Go to Trials
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