Stigma Management Interventions for HIV

(Yomelela Trial)

Not currently recruiting at 1 trial location
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Connecticut
Must be taking: Antiretrovirals

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to improve the health and care of people living with HIV by testing different counseling approaches to manage HIV-related stigma. Participants will receive either standard HIV counseling, counseling with self-regulation skills, or counseling with both self-regulation skills and stigma management. The goal is to determine which method best helps people remain in care and adhere to their medication. This trial suits individuals with unsuppressed HIV (not controlled, meaning the virus is still detectable in their blood) who have access to a phone but are not part of an adherence club. As an unphased trial, this study offers a unique opportunity to explore innovative counseling methods that could enhance care and support.

Do I have to stop taking my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It focuses on managing HIV stigma to improve medication adherence, so it's likely you will continue your current HIV treatment.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that behavioral counseling, such as Behavioral Self-Regulation Skills Counseling, is generally safe and well-received. Studies have found it helps people take their medication more regularly when delivered via mobile phone, with no reports of harmful effects. This counseling adapts easily to different cultures and is delivered by trained community members, making it accessible and safe for many communities.

For Behavioral Self-Regulation Skills Counseling combined with Stigma Management, research also supports its safety. Programs aimed at reducing HIV-related stigma have helped patients follow their treatment plans. These methods focus on reducing stigma and improving mental health, both crucial for people living with HIV.

Overall, both types of counseling are non-invasive and mainly involve talking and support. They are designed to help without causing harm, making them a safe option for those considering joining a clinical trial.12345

Why are researchers excited about this trial?

Researchers are excited about these interventions because they focus on enhancing HIV care through innovative counseling approaches. The Behavioral Self-Regulation Skills Counseling uses mobile phone-delivered sessions to help patients stick to their HIV treatment by involving culturally tailored support, which is more accessible and personal than traditional methods. Additionally, the version with added Stigma Management directly targets the stigma-related issues that patients face, which is a crucial barrier to effective treatment that standard care doesn't address. These approaches aim to improve patient retention in care and help maintain viral suppression, offering a more holistic and supportive strategy for managing HIV.

What evidence suggests that this trial's treatments could be effective for managing HIV-related stigma?

Research shows that counseling to manage behavior can significantly improve adherence to HIV medication. In this trial, some participants will receive Behavioral Self-Regulation Skills Counseling, which studies have found more effective in helping patients maintain their medication schedules compared to the Uniform Standard of Care Counseling. This counseling also aids in keeping individuals in treatment, crucial for effective HIV management.

Another group in this trial will receive Behavioral Self-Regulation Skills Counseling combined with Stigma Management. Addressing stigma can enhance the counseling's effectiveness. A review found that programs focusing on reducing stigma not only diminish the stigma itself but also improve medication adherence. This approach is particularly beneficial in communities with high HIV stigma, leading to better health outcomes for those living with the virus.26789

Are You a Good Fit for This Trial?

This trial is for adults over 18 with HIV who are not currently in an adherence club but visit a clinic for antiretroviral therapy, have unsuppressed HIV at their latest test, and own a phone. It's not open to those who don't meet these conditions.

Inclusion Criteria

Unsuppressed HIV at the most recent clinical testing confirmed in run-in
Access to a phone
I am visiting the clinic for my HIV treatment outside of an adherence club.

Exclusion Criteria

Not meeting inclusion

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive mobile phone-delivered counseling to improve HIV care retention and medication adherence, with some receiving additional stigma management components

12 months
Monthly unannounced phone assessments

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Behavioral Self-Regulation Skills Counseling
  • Behavioral Self-Regulation Skills Counseling + Stigma Management
  • Uniform Standard of Care Counseling
Trial Overview The study tests interventions to manage HIV-related stigma: one group receives Behavioral Self-Regulation Skills Counseling; another gets this plus Stigma Management; and a third gets standard care counseling. The goal is better care retention and medication adherence.
How Is the Trial Designed?
3Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Behavioral Self-Regulation Skills Counseling + Stigma ManagementExperimental Treatment1 Intervention
Group II: Behavioral Self-Regulation Skills CounselingActive Control1 Intervention
Group III: Uniform Standard of Care CounselingPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Connecticut

Lead Sponsor

Trials
194
Recruited
162,000+

Medical Research Council, South Africa

Collaborator

Trials
76
Recruited
206,000+

Citations

Brief Behavioral Self-Regulation Counseling for HIV ...The self-regulation counseling delivered by cell phone demonstrated significant improvements in adherence compared to the control condition.
Comparative effects of telephone versus in-office behavioral ...The current trial tested the effects of behavioral self-regulation counseling on retention in care (primary outcome), HIV medication adherence ...
The importance of self-management for better treatment ...The aim of this research is to understand the perspectives of service providers and experts on the importance of self-management for PLWH.
A process and impact evaluation of a peer-led HIV self- ...In the overall sample, there were statistically significant improvements in HIV-related knowledge, social support, patient self-advocacy, and confidence in self ...
Medication Self-Efficacy Among Participants Allocated to ...These studies indicate that mHealth technologies are effective in self-care and counselling interventions in the context of HIV prevention and treatment; ...
Cognitive Behavioral Therapy as a Game Changer in HIV ...Regarding primary outcomes, the analysis demonstrated that CBT did not significantly reduce sexual transmission risk behavior after four or ...
Counselling behavioural interventions for HIV, STI and viral ...Meta-analysis of six RCTs showed no statistically significant effect of counselling behavioural interventions on HIV incidence (1280 ...
Promising outcomes from a cognitive behavioral therapy ...Those who received TXT-CBT reduced HIV-risk behaviors and increased their self-efficacy related to medication adherence. •. TXT-CBT is a potentially scalable ...
Self-management interventions for adolescents living with HIVExisting evidence on the effectiveness of self-management interventions for improving health-related outcomes of ALHIV is very uncertain. Self- ...
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