PATH Tool for Aging with HIV/AIDS

(PATH Trial)

Not yet recruiting at 1 trial location

Overseen By Christina Baucco, BS

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Indiana University

Disqualifiers: Nursing home, Geriatric care, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 4

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new tool called PATH, which stands for Promoting Aging and Thriving with HIV. The goal is to determine if the PATH toolkit can help older adults living with HIV manage aging-related issues more effectively in HIV clinics. Participants will either receive their usual care or undergo an assessment using the PATH toolkit before their medical appointments. The study seeks individuals aged 50 or older who have received HIV care at specific clinics in the past year. As an unphased trial, it offers a unique opportunity to contribute to innovative research that could enhance the quality of care for older adults living with HIV.

Do I need to stop my current medications to join the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that the PATH tool is safe for aging with HIV/AIDS?

Research has shown limited specific information on the safety of the PATH tool for people aging with HIV. This trial is a pilot study, indicating early stages with potentially limited safety data. However, as PATH is an assessment and management tool, not a drug or surgery, it likely poses low risk. Such tools typically aim to enhance healthcare and are generally user-friendly. Participants will use the PATH toolkit in outpatient HIV clinics, undergoing an aging assessment before their medical appointment. This approach is designed to improve care rather than introduce new treatments, suggesting it is safe. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about the PATH tool for aging with HIV/AIDS because it offers a personalized approach to managing the unique challenges faced by older adults living with HIV. Unlike standard care, which typically involves general information on HIV and aging, the PATH method includes a detailed aging assessment tailored to individual needs. This personalized assessment can help healthcare providers better understand and address specific aging-related issues, potentially leading to improved health outcomes and quality of life for participants. By focusing on personalized care, the PATH tool has the potential to transform how aging with HIV is managed.

What evidence suggests that the PATH tool is effective for aging with HIV/AIDS?

Research has shown that aging can greatly affect the health of people living with HIV. The PATH tool, one of the study interventions, aims to support healthy aging while managing HIV. Early studies suggest that tools like PATH can improve health for older adults with HIV, helping them live healthier and longer lives. This makes PATH an exciting option for those wanting to manage both aging and HIV effectively. Participants in this trial will either receive usual care or undergo an aging assessment using the PATH toolkit. ^{3 6 7 8 9}

Who Is on the Research Team?

Meredith Greene, MD

Principal Investigator

Indiana University School of Medicine, and Regenstrief Institute; IU Center for Aging Research

Are You a Good Fit for This Trial?

This trial is for older adults with HIV/AIDS who may also have Diffuse Large B-Cell Lymphoma. It's designed to assess how a specialized geriatric assessment and management tool can be integrated into their routine HIV care.

Inclusion Criteria

Receive HIV care (at least 1 visit at the same site within the past 12 months) from either Eskenazi Health IDC or LifeCare clinics

Able to provide informed consent

I am 50 years old or older.

Exclusion Criteria

Patients who are receiving geriatric care services, however will liberalize this criteria if difficulty with recruitment

I live in a nursing home long-term.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Baseline assessments including surveys and chart reviews to measure unmet needs and quality of life

1 week

1 visit (in-person)

Intervention

Participants undergo geriatric assessment and management using the PATH toolkit or receive usual care

6 months

Regular visits as per usual care or PATH protocol

Follow-up

Participants are monitored for safety and effectiveness after intervention, including qualitative interviews

6 months

3 visits (in-person) at 3-month intervals

What Are the Treatments Tested in This Trial?

Interventions

• Promoting Aging and Thriving with HIV (PATH)

Trial Overview The study is testing the PATH program, which involves implementing a tailored geriatric assessment and management strategy in outpatient HIV clinics to improve the care of aging individuals with HIV.

How Is the Trial Designed?

Group I: PATH Experimental Treatment 1 Intervention

The PATH group will undergo an aging assessment using the PATH toolkit before their regular medical appointment.

Group II: Usual Care Active Control 1 Intervention

Usual care participants will receive HIV and aging information before their regular medical appointment.

Who Is Running the Clinical Trial?

Indiana University

Lead Sponsor

Trials

1,063

Recruited

1,182,000+

National Institute on Aging (NIA)

Collaborator

Trials

1,841

Recruited

28,150,000+

Citations

1. grants.nih.gov grants.nih.gov/grants/guide/pa-files/PAR-25-354.html

PAR-25-354: Multidisciplinary Studies of HIV/AIDS and ... Aging is, by itself, a key factor promoting the development of many cancers, and HIV infection can itself cause certain manifestations of ...

2. researchprotocols.org researchprotocols.org/2025/1/e72471

Emerging Interventions to Improve Health Outcomes for ... To the best of our knowledge, our study is one of the first of its kind to evaluate various aging-support interventions for people with HIV in ...

3. hiv.gov hiv.gov/blog/supporting-research-for-older-adults-living-with-hiv

Supporting Research for Older Adults Living with HIV NIA has long been committed to research promoting healthy aging among older adults living with HIV. We are pleased to share a few relevant upcoming ...

4. grants.hrsa.gov grants.hrsa.gov/2010/Web2External/Interface/Common/EHBDisplayAttachment.aspx?dm_rtc=16&dm_attid=71a6e7fb-bcb8-4886-8aec-58351c1a2862&dm_attinst=0

Emerging Strategies to Improve Health Outcomes for ... Health Outcomes for People Aging with HIV. ... Do people living with. HIV experience greater age advancement than their HIV-negative counterparts?

5. viivhealthcare.com viivhealthcare.com/en-us/ending-hiv/our-science/40-years-of-innovation-from-surviving-to-thriving/

Aging (and Thriving) with HIV By 2030, it's estimated that 70% of the U.S. population living with HIV will be over age 50. A number of important scientific milestones made this remarkable ...

6. aidsvu.org aidsvu.org/resources/toolkits/national-hiv-aids-and-aging-awareness-day-toolkit-2025/

National HIV/AIDS and Aging Awareness Day Toolkit 2025 Only 19% of individuals 65+ had ever been tested for HIV as of 2022. • In 2023, just 71% of people 65+ living with HIV received care — the ...

7. reporter.nih.gov reporter.nih.gov/search/EaC3BhVN6USBfOMuTswDVQ/project-details/10789932

RePORT ⟩ RePORTER We're sorry but RePORTER doesn't work properly without JavaScript enabled. Please enable it to continue.

8. cdc.gov cdc.gov/hiv-data/nhss/national-hiv-prevention-and-care-outcomes.html

National HIV Prevention and Care Objectives | HIV Data In 2022, over 80% of people with diagnosed HIV were linked to care within one month of diagnosis. Only 76% had received some care, 54% were retained in care, ...

9. healthhiv.org healthhiv.org/pozitivelyaging/

Pozitively Aging HealthHIV's Pozitively Aging program improves access to services and care coordination for people with HIV (PWH) over 50 and health outcomes through enhancing ...