SGLT2 Inhibitors for Pediatric Brain Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing whether dapagliflozin, a drug that helps lower blood sugar, is safe for brain tumor patients who are receiving chemotherapy. The goal is to see if the medication can be used without causing significant side effects. Dapagliflozin works by helping the kidneys remove sugar from the blood, which is then passed out in urine.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot be on high doses of dexamethasone or insulin. If you're on dexamethasone, you need to be on a stable or decreasing dose before starting the trial.
Is dapagliflozin generally safe for humans?
How do SGLT2 inhibitors differ from other drugs for pediatric brain cancer?
What data supports the effectiveness of the drug Dapagliflozin for pediatric brain cancer?
Research suggests that SGLT2 inhibitors like Dapagliflozin may help slow down cancer growth by reducing glucose uptake in cancer cells, as seen in studies with breast cancer. While this is promising, more research is needed to confirm its effectiveness specifically for pediatric brain cancer.3891011
Who Is on the Research Team?
Andrew Cluster, M.D.
Principal Investigator
Washington University School of Medicine
Are You a Good Fit for This Trial?
This trial is for children and young adults aged 6-21 with recurrent primary brain tumors, who have tried other treatments like radiation or chemotherapy. They must have a life expectancy over 12 weeks, stable vital signs, and normal organ function. Participants need to agree to use contraception if they can have children.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive dapagliflozin in addition to standard of care chemotherapy for 12 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
Long-term follow-up
Participants are monitored for long-term safety and tumor response
What Are the Treatments Tested in This Trial?
Interventions
- Dapagliflozin
Find a Clinic Near You
Who Is Running the Clinical Trial?
Washington University School of Medicine
Lead Sponsor
Children's Discovery Institute
Collaborator
Children's Discovery Institute
Collaborator