Physical Activity and Education for Colorectal Cancer
(CHALLENGE Trial)
Trial Summary
Do I have to stop taking my current medications to join the trial?
The trial does not specify if you need to stop taking your current medications, but you cannot be on any concurrent anticancer treatment, including chemotherapy, biological, or targeted agents. You also cannot take medications that the investigator thinks might prevent you from participating in the physical activity program.
What data supports the effectiveness of the treatment Health Education Materials, Physical Activity Program for colorectal cancer?
Is physical activity safe for people with colorectal cancer?
How does the Physical Activity Program and Health Education Materials treatment differ from other treatments for colorectal cancer?
This treatment is unique because it focuses on incorporating physical activity and health education to improve quality of life and potentially reduce mortality in colorectal cancer patients, rather than relying solely on traditional medical treatments like surgery or chemotherapy. Physical activity is shown to have benefits such as slowing functional decline and improving overall survival, which are not typically addressed by standard cancer treatments.346910
What is the purpose of this trial?
RATIONALE: Participating in a physical activity program designed to increase free time physical activity and receiving written health education materials may influence the chance of cancer recurring as well as impact on physical fitness, psychological well-being and the quality of life of patients who have undergone surgery and chemotherapy for colon cancer. It is not yet known whether giving a physical activity program together with health education materials is more effective than giving health education materials alone for patients who have undergone colon cancer treatment.PURPOSE: This randomized phase III trial is studying a physical activity program given together with health education materials to see how well it works compared with giving health education materials alone for patients who have undergone treatment for high-risk stage II or stage III colon cancer.
Research Team
Janette Vardy, PhD, FRACP
Principal Investigator
Sydney Cancer Centre at Concord Repatriation General Hospital
Kerry Courneya, PhD
Principal Investigator
University of Alberta
Christopher Booth, MD
Principal Investigator
Cancer Centre of Southeastern Ontario at Kingston General Hospital
Eligibility Criteria
This trial is for patients who've completed certain chemotherapy for high-risk stage II or III colon cancer within the last 60-180 days. They should be able to communicate, complete questionnaires and exercise tests, not meet current physical activity guidelines, and have no evidence of recurring cancer. Pregnant individuals or those planning pregnancy in the next 3 years are excluded.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Intensive Intervention
Participants undergo 12 mandatory biweekly face-to-face behavior support sessions combined with 12 mandatory supervised physical activity sessions to increase their physical activity goal by 10 MET hours/week.
Reduced Intervention
Participants undergo 12 mandatory biweekly face-to-face or telephone behavior support sessions combined with 12 recommended supervised physical activity sessions to increase their physical activity goal by 20 MET hours/week.
Minimal Intervention
Participants undergo mandatory monthly face-to-face or telephone behavior support sessions combined with recommended supervised physical activity sessions to increase their physical activity goal to a maximum total of 27 MET hours/week.
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Health Education Materials
- Physical Activity Program
Find a Clinic Near You
Who Is Running the Clinical Trial?
Canadian Cancer Trials Group
Lead Sponsor
Queen's University, Belfast
Collaborator
Survivorship Research Group
Collaborator