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Nonsteroidal Anti-inflammatory Drug

Ketorolac for Blood Vessel Function (VDR Trial)

Phase < 1
Recruiting
Research Sponsored by Milton S. Hershey Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Weigh over 50 kg
Aged between 21 and 35 years (inclusive)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 blood draws during the 3-4 hour study visit.
Awards & highlights

VDR Trial Summary

This trial is studying whether ketorolac, an IV NSAID, can reduce the response of the muscle sympathetic nerve to limb venous distention.

Who is the study for?
This trial is for healthy adults aged 21-35, fluent in English, weighing over 50 kg, and without chronic medical conditions. Participants must not have taken NSAIDs recently or be allergic to them. Pregnant women, individuals with high blood pressure or metal implants, and those on certain medications are excluded.Check my eligibility
What is being tested?
The study tests how ketorolac tromethamine (a painkiller) affects the body's response to vein stretching in the arm. It compares this drug's effect with a saline solution using MRI scans to observe changes in vein size during the process.See study design
What are the potential side effects?
Ketorolac may cause side effects like stomach upset or bleeding, allergic reactions similar to ibuprofen or aspirin allergies, and possibly an increased risk of heart attack or stroke if used long-term.

VDR Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I weigh more than 50 kg.
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I am between 21 and 35 years old.
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I do not have any ongoing serious health issues.

VDR Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~recorded continuously during the 3-4 hour study visit
This trial's timeline: 3 weeks for screening, Varies for treatment, and recorded continuously during the 3-4 hour study visit for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Microneurography (MSNA)
Vein size with MRI
Secondary outcome measures
Blood Pressure
Heart Rate
Impedance
+2 more
Other outcome measures
Biochemistry
Forearm volume

VDR Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: KetorolacExperimental Treatment2 Interventions
The Wrist-to-Elbow occlusion procedure will be performed followed by 2 ketorolac tromethamine + saline infusions into the occluded arm.
Group II: ControlPlacebo Group2 Interventions
The Wrist-to-Elbow occlusion procedure will be performed followed by 2 saline only infusions into the occluded arm.

Find a Location

Who is running the clinical trial?

Milton S. Hershey Medical CenterLead Sponsor
494 Previous Clinical Trials
2,798,824 Total Patients Enrolled

Media Library

Ketorolac Tromethamine (Nonsteroidal Anti-inflammatory Drug) Clinical Trial Eligibility Overview. Trial Name: NCT03513770 — Phase < 1
Venous Distension Reflex Research Study Groups: Ketorolac, Control
Venous Distension Reflex Clinical Trial 2023: Ketorolac Tromethamine Highlights & Side Effects. Trial Name: NCT03513770 — Phase < 1
Ketorolac Tromethamine (Nonsteroidal Anti-inflammatory Drug) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03513770 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To whom is eligibility for this medical experiment available?

"Eligibility requirements to partake in this trial include age (between 21 and 35) as well as a healthy blood pressure. A total of 18 participants will be welcomed into the study."

Answered by AI

Have there been any other investigations into the effects of Wrist-to-elbow (W-E) occlusion?

"At present, there are 38 ongoing trials that investigate Wrist-to-elbow (W-E) occlusion with 8 of them being in their third phase. The investigations take place across 57 sites located mainly in Los Angeles, California."

Answered by AI

What is the aggregate count of participants enrolled in this trial?

"The data on clinicaltrials.gov validates that this medical study is recruiting at the moment. It was first listed online on August 14th 2019, and last updated January 10th 2022. The trial requires 18 individuals to participate via one site only."

Answered by AI

Are participants aged 50 and above being accepted for this clinical trial?

"This trial has a restricted age range of 21 to 35 years old. There are 24 additional studies for minors and 131 trials available for seniors aged 65 or older."

Answered by AI

What is the overarching purpose of this clinical trial?

"This medical trial's primary outcome, observed over a span of three to four hours, is the measurement of vein size using MRI imaging. Secondary objectives include non-invasive skin blood flow measurements with laser-Doppler flowmetry, various EKG readings for heart rate monitoring and strain gauge evaluations which measure changes in circumference levels on the forearm."

Answered by AI

Is there currently an opportunity for patients to register for this research?

"Indeed. According to clinicaltrials.gov, this medical study is still accepting participants - it was first posted on August 14th 2019 and the listing has been recently updated as of January 10th 2022. Currently, 18 volunteers are required for a single location."

Answered by AI

What medical conditions can be addressed through the use of Wrist-to-elbow (W-E) occlusion?

"Wrist-to-elbow occlusion is traditionally used to combat ocular itching, but can also offer relief from pain, induce a nerve block, and alter pupil size."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Autonomic Control of the Circulation and VDR
Jian Cui 2019. "Autonomic Control of the Circulation and VDR". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03513770.
~4 spots leftby Jul 2025
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