Lorazepam for PTSD
Trial Summary
Do I need to stop my current medications to join the trial?
You may need to stop certain medications, especially if they interact unsafely with lorazepam. However, other psychotropic medications are allowed if they are at a stable dose for at least 2 weeks and do not have unsafe interactions with the study drug.
Is lorazepam generally safe for humans?
How does the drug lorazepam differ from other treatments for PTSD?
Lorazepam is a benzodiazepine primarily used for anxiety, insomnia, and other conditions, but its use for PTSD is less common compared to other treatments like phenelzine. Unlike phenelzine, which is an antidepressant, lorazepam works by enhancing the effect of a neurotransmitter called GABA, which helps calm the nervous system.46789
What is the purpose of this trial?
A substantial majority of Veterans with posttraumatic stress disorder (PTSD) continue to suffer even with the best current medications. Progress in developing more effective medications is hampered by the substantial variability within Veterans with PTSD, meaning the most effective medication likely varies from individual to individual. New scientific tools to help identify distinct subgroups of Veterans with PTSD who are likely to respond to specific medications could help improve treatment in this population. Research has indicated that a specific subgroup of Veterans with PTSD with a high level of anxious arousal may benefit from medications which boost signaling of the neurotransmitter gamma-aminobutyric acid (GABA). This project aims to validate a clinical test to identify these individuals using new computational and neuroimaging methods combined with the medication lorazepam, a positive GABA modulator. The ultimate goal is to use these methods in future clinical trials of new medications to target the best treatments to individual Veterans with PTSD.
Research Team
Jonathan R Howlett, MD
Principal Investigator
VA San Diego Healthcare System, San Diego, CA
Eligibility Criteria
This trial is for Veterans with PTSD, particularly those who experience high levels of anxious arousal. Participants must meet specific criteria that will be determined by the study's inclusion and exclusion details.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a single dose of lorazepam or placebo in a randomized crossover design, with a 1-week washout period between sessions
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Lorazepam
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor