Rifabutin

Mycobacterium avium complex infection, prophylaxis of Mycobacterium avium complex infection, Tuberculosis + 3 more
Treatment
3 FDA approvals
20 Active Studies for Rifabutin

What is Rifabutin

RifabutinThe Generic name of this drug
Treatment SummaryA broad-spectrum antibiotic used to prevent the spread of Mycobacterium avium complex infection in people with HIV.
Mycobutinis the brand name
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Rifabutin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Mycobutin
Rifabutin
1992
10

Approved as Treatment by the FDA

Rifabutin, also known as Mycobutin, is approved by the FDA for 3 uses like Mycobacterium avium complex infection and prophylaxis of Mycobacterium avium complex infection .
Mycobacterium avium complex infection
prophylaxis of Mycobacterium avium complex infection
HIV

Effectiveness

How Rifabutin Affects PatientsRifabutin is an antibiotic used to fight bacteria. It works by stopping bacteria from making proteins needed for their survival. It kills both gram-positive and gram-negative bacteria and is especially effective against Mycobacterium tuberculosis. However, it is only used for a few specific infections because bacteria can quickly become resistant to it. When taken orally, rifabutin is easily absorbed and spread throughout the body, including in the brain. It is broken down in the liver and removed from the body through bile and urine. It does not need to be adjusted for people with kidney problems.
How Rifabutin works in the bodyRifabutin works by stopping bacteria from making new RNA, which in turn leads to the death of the bacteria.

When to interrupt dosage

The advised dosage of Rifabutin is dependent upon the perceived situation, such as HIV, Stomach Ulcer and Tuberculosis (TB). The degree of dosage shifts, in agreement with the method of delivery (e.g. Capsule - Oral or Capsule, delayed release) indicated in the table beneath.
Condition
Dosage
Administration
Helicobacter Pylori Infection
150.0 mg, , 12.5 mg
, Oral, Capsule, Capsule - Oral, Capsule, delayed release - Oral, Capsule, delayed release
Mycobacterium avium complex infection
150.0 mg, , 12.5 mg
, Oral, Capsule, Capsule - Oral, Capsule, delayed release - Oral, Capsule, delayed release
prophylaxis of Mycobacterium avium complex infection
150.0 mg, , 12.5 mg
, Oral, Capsule, Capsule - Oral, Capsule, delayed release - Oral, Capsule, delayed release
Tuberculosis
150.0 mg, , 12.5 mg
, Oral, Capsule, Capsule - Oral, Capsule, delayed release - Oral, Capsule, delayed release
HIV
150.0 mg, , 12.5 mg
, Oral, Capsule, Capsule - Oral, Capsule, delayed release - Oral, Capsule, delayed release
Tuberculosis
150.0 mg, , 12.5 mg
, Oral, Capsule, Capsule - Oral, Capsule, delayed release - Oral, Capsule, delayed release

Warnings

Rifabutin Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Rifabutin.
Common Rifabutin Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Rifabutin.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Rifabutin.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Rifabutin.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Rifabutin.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Rifabutin.
Rifabutin Toxicity & Overdose RiskThe toxic dose of this drug in male mice has been found to be 4.8 g/kg.
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Rifabutin Novel Uses: Which Conditions Have a Clinical Trial Featuring Rifabutin?

127 active clinical trials are being conducted to investigate the potential of Rifabutin to provide prophylaxis against Mycobacterium avium complex infection, Stomach Ulcer and Tuberculosis (TB).
Condition
Clinical Trials
Trial Phases
HIV
132 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
Tuberculosis
0 Actively Recruiting
prophylaxis of Mycobacterium avium complex infection
0 Actively Recruiting
Helicobacter Pylori Infection
1 Actively Recruiting
Not Applicable
Tuberculosis
7 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4
Mycobacterium avium complex infection
1 Actively Recruiting
Phase 2, Phase 3

Rifabutin Reviews: What are patients saying about Rifabutin?

1Patient Review
10/6/2014
Rifabutin for Mycobacterium Avium Bacteria Infection
I'm only two weeks in on this medication, and I can't take it anymore. The side effects are unbearable.
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Patient Q&A Section about rifabutin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is another name for rifabutin?

"Rifabutin can help to prevent Mycobacterium avium complex, which is a serious bacterial infection that mostly affects people who have HIV."

Answered by AI

What kind of antibiotic is rifabutin?

"Rifabutin is a medication used to treat infections caused by bacteria. It works by killing the bacteria that cause infection. Rifabutin will not work for colds, flu, or other viral infections."

Answered by AI

What are side effects of rifabutin?

"Burning, dry or red eyes, watery diarrhea, severe pain or tenderness in stomach, and itching or discharge in eyes are all symptoms of pink eye."

Answered by AI

What is rifabutin used for?

"Rifabutin is a medication used to help prevent MAC disease caused by Mycobacterium avium or Mycobacterium intracellulare bacteria from affecting the body in patients with advanced HIV infection."

Answered by AI

Clinical Trials for Rifabutin

Have you considered Rifabutin clinical trials? We made a collection of clinical trials featuring Rifabutin, we think they might fit your search criteria.
Have you considered Rifabutin clinical trials? We made a collection of clinical trials featuring Rifabutin, we think they might fit your search criteria.
Have you considered Rifabutin clinical trials? We made a collection of clinical trials featuring Rifabutin, we think they might fit your search criteria.
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