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What is Hepsera
Adefovir dipivoxilThe Generic name of this drug
Treatment SummaryAdefovir dipivoxil, also known as Preveon or Hepsera, is an oral medication used to treat hepatitis B. It is not effective against HIV-1. Adefovir dipivoxil is the prodrug form of the active drug adefovir, meaning it is converted into the active drug in the body.
Hepserais the brand name
Hepsera Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Hepsera
Adefovir dipivoxil
2002
4
Approved as Treatment by the FDA
Adefovir dipivoxil, otherwise known as Hepsera, is approved by the FDA for 1 uses which include Chronic Hepatitis B Infection .Chronic Hepatitis B Infection
Helps manage Hepatitis B Chronic Infection
Effectiveness
How Hepsera Affects PatientsAdefovir dipivoxil is a drug derived from adefovir. Adefovir is an antiviral used to treat human hepatitis B virus (HBV). It works by blocking the production of a protein used by HBV to replicate. In laboratory tests, adefovir was found to be effective at concentrations between 0.2 and 2.5 μM in cells infected with HBV. Combining adefovir with lamivudine has been shown to increase its effectiveness.
How Hepsera works in the bodyAdefovir dipivoxil is a drug that treats hepatitis B. It works by converting to its active form, adefovir diphosphate, and binding to the virus' DNA polymerase. This competition with the natural substrate of the virus stops the virus' ability to replicate and therefore helps to slow its spread. Adefovir diphosphate also weakly binds to human DNA polymerases, but not enough to be considered harmful.
When to interrupt dosage
The advocated portion of Hepsera is contingent upon the diagnosed condition. The dosage amount is contingent upon the delivery technique (e.g. Tablet - Oral or Tablet) outlined in the following table.Condition
Dosage
Administration
Chronic Hepatitis B Infection
10.0 mg,
, Oral, Tablet, Tablet - Oral
Warnings
There are 20 known major drug interactions with Hepsera.Common Hepsera Drug Interactions
Drug Name
Risk Level
Description
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Neomycin.
Tenofovir
Major
The serum concentration of Tenofovir can be increased when it is combined with Adefovir dipivoxil.
Tenofovir alafenamide
Major
The serum concentration of Tenofovir alafenamide can be increased when it is combined with Adefovir dipivoxil.
Tenofovir disoproxil
Major
The serum concentration of Tenofovir disoproxil can be increased when it is combined with Adefovir dipivoxil.
Abacavir
Minor
Adefovir dipivoxil may decrease the excretion rate of Abacavir which could result in a higher serum level.
Hepsera Toxicity & Overdose RiskHigh doses of adefovir dipivoxil may lead to kidney damage, which can be observed through changes in blood and urine tests. This type of toxicity has been seen in animals with blood levels 3 to 10 times higher than those seen in humans taking the recommended dose of 10 mg per day.
Hepsera Novel Uses: Which Conditions Have a Clinical Trial Featuring Hepsera?
Currently, 3 active trials are underway to assess the potential of Hepsera in managing Chronic Hepatitis B.Condition
Clinical Trials
Trial Phases
Chronic Hepatitis B Infection
7 Actively Recruiting
Phase 3, Phase 2, Phase 1
Hepsera Reviews: What are patients saying about Hepsera?
5Patient Review
1/16/2009 I've been on Hepsera for over 10 years now and it's kept me in good shape. My virus count is low and my specialist says everything looks great. I'm still taking the medication and hoping for a cure, but so far this has been the best treatment available.
5Patient Review
3/13/2008 I started taking this medication 2004 and saw amazing results over the next few years. My bilirubi count went from 35 to 1.8 in 2008.
5Patient Review
9/2/2008 I've been using Hepsera for about two years now and it's worked great. My viral count is down to an undetectable level. I'm very happy with the results so far, although I was told there may be some resistance developing. If anyone else has experienced problems with burping or belching, please let me know.
5Patient Review
11/28/2007 I've been on Hepsera for close to two years now, and it's been great in helping my hepatitis B stay in remission.
5Patient Review
1/26/2009 I've been on this medication for seven years now and it's really helped me. I get blood work done every six months to keep an eye on things, but so far everything looks great.
5Patient Review
6/22/2009 This treatment has been working well for me so far. My hep levels have stayed down and I'm not as scared anymore.
4.7Patient Review
10/29/2007 I started this treatment over a year ago and saw great results. My numbers have been steadily improving and I'm very pleased with the progress.
4.3Patient Review
4/24/2014 I took Hepsera for more than 10 years. I am now taking a different medicine. I didn't have many side effects and it worked well for me.
4Patient Review
3/18/2016 While it's not a cure, this medication has been great for managing my hepatitis B. I've been taking it for 13 years and my viral count has been undetectable the entire time. However, my doctors won't recommend that I stop taking the medication because it is so expensive. I hope and pray that someday there will be a cure for this disease.
4Patient Review
10/18/20074Patient Review
10/11/2010 While this drug did contain the virus, it unfortunately also damaged my kidney. My doctor advised me to continue taking it and hope that the kidney damage would not progress.
Patient Q&A Section about hepsera
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How do you take Hepsera?
"The ordinary portion size is one 10 milligram tablet every day. You can take the tablet either with or without food. Attempt to take your doses at a similar time each day, as this will assist you with recalling to take adefovir all the time."
Answered by AI
What is the generic of Hepsera?
"Hepsera is a brand-name drug that costs about $1,876.67 to fill a prescription. However, you can reduce your Hepsera cost by purchasing the generic version of Hepsera, adefovir, or by using a SingleCare Hepsera coupon to reduce your price to $250.60 per 30, 10MG Tablet."
Answered by AI
What is Hepsera used for?
"HEPSERA is not a cure for hepatitis b. Use of other antiviral medicines with HEPSERA may increase the chance of serious side effects.
The medicine HEPSERA is used to treat people aged 12 and over who have chronic (long-lasting) infections with active hepatitis B virus. It is not for use in children under the age of 12. HEPSERA may lower the amount of hepatitis B virus (HBV) in your body, and it may improve the condition of your liver. However, it is not a cure for hepatitis B. If you use other antiviral medicines with HEPSERA, the chance of serious side effects increases."
Answered by AI
How long do you take Hepsera?
"Adefovir dipivoxil doses of 500 mg given daily for 2 weeks, followed by 250 mg given daily for 12 weeks, have been associated with gastrointestinal side effects."
Answered by AI