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What is Aldomet
MethyldopaThe Generic name of this drug
Treatment SummaryMethyldopa is a medication used to lower blood pressure. It works by blocking certain signals in the body that cause high blood pressure. Methyldopa was first introduced in 1960 and is usually taken as a pill or injection. It is most commonly used in pregnant women or those with kidney problems. Although there are newer, better-tolerated medications to treat high blood pressure, methyldopa is still used either by itself or in combination with other medications.
Aldorilis the brand name
Aldomet Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Aldoril
Methyldopa
1962
32
Approved as Treatment by the FDA
Methyldopa, otherwise known as Aldoril, is approved by the FDA for 1 uses like Hypertensive disease .Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Effectiveness
How Aldomet Affects PatientsMethyldopa works by decreasing the activity of the sympathetic nervous system, which helps to lower blood pressure. It can also reduce the levels of certain hormones and neurotransmitters in the body. When taken orally, it typically starts working within 12 to 24 hours and its effects typically peak within 4 to 6 hours. Once taken, the drug will remain in the body for 24 to 48 hours after it is stopped. When taken intravenously, the effects last for 10 to 16 hours.
How Aldomet works in the bodyMethyldopa helps reduce blood pressure by working on two different pathways in the body. It stimulates alpha-2 adrenergic receptors in the brainstem, which reduces the amount of norepinephrine released in the area. This decreases the signals sent to the peripheral nervous system that produce constriction of blood vessels. Methyldopa also inhibits an enzyme called DOPA decarboxylase, which helps to deplete biogenic amines like norepinephrine. However, this effect only plays a minor role in the blood-pressure-lowering effect of methyldopa.
When to interrupt dosage
The suggested measure of Aldomet is based upon the ascertained affliction, including Therapeutic procedure, Hypertensive crisis and Hypertensive disease. The amount of dosage fluctuates as per the system of delivery (e.g. Intravenous or Tablet, film coated - Oral) specified in the accompanying table.Condition
Dosage
Administration
Therapeutic procedure
250.0 mg, , 500.0 mg, 50.0 mg/mL, 125.0 mg, 250.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous
Hypertensive crisis
250.0 mg, , 500.0 mg, 50.0 mg/mL, 125.0 mg, 250.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous
Hypertensive disease
250.0 mg, , 500.0 mg, 50.0 mg/mL, 125.0 mg, 250.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous
Warnings
Aldomet has four contraindications, so it should not be consumed if any of the conditions in the ensuing table are present.Aldomet ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
history of liver disorders caused by methyldopa
Do Not Combine
active hepatic disease
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Methyldopa may interact with Pulse Frequency
Common Aldomet Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Methyldopa may increase the hypotensive activities of Amifostine.
Iobenguane
Major
The therapeutic efficacy of Iobenguane can be decreased when used in combination with Methyldopa.
Abacavir
Minor
Methyldopa may decrease the excretion rate of Abacavir which could result in a higher serum level.
Aclidinium
Minor
Methyldopa may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Methyldopa may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Aldomet Toxicity & Overdose RiskThe smallest toxic amount of methyldopa taken orally is 44gm/kg/3Y for a female. In rats and mice, the lethal dose when taken orally is 5000mg/kg and 5300mg/kg respectively. When taken intraperitoneally, it is 300mg/kg in rats and 150mg/kg in mice. Overdosing on methyldopa can lead to low blood pressure, fatigue, weakness, slow heart rate, dizziness, lightheadedness, constipation, bloating, diarrhea, nausea, and vomiting. Treatment includes removing the drug from the body by inducing vomiting or gastric lav
Aldomet Novel Uses: Which Conditions Have a Clinical Trial Featuring Aldomet?
18 active studies are assessing the potential of Aldomet to provide therapeutic intervention, ameliorate Hypertensive disease and manage Hypertensive crises.Condition
Clinical Trials
Trial Phases
Hypertensive crisis
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Aldomet Reviews: What are patients saying about Aldomet?
5Patient Review
4/26/2010 I've been taking aldomet for five years to manage my high blood pressure, and it's been working great. The only side effect I've noticed is that it makes me sleepy, which actually isn't a bad thing considering how much stress I'm under on a daily basis.
5Patient Review
4/7/2010 So far, this medication has been great for managing my pregnancy-induced hypertension. I was originally on Labetalol starting at 16 weeks, but the side effects were getting worse and I had to stop taking it. Aldomet 250mg twice a day has controlled my BP without any unwanted side effects.
4.7Patient Review
6/20/2010 Clonidine hadn't been working well for me in terms of keeping my blood pressure down, but as soon as I started taking Methlydopa things changed very quickly.
4.7Patient Review
5/17/2008 While this medication is very effective, it's also extremely dangerous. My mother took it for years and eventually died of pancreatic cancer as a result of the liver and digestive complications it caused. I would urge everyone to stay away from this drug.
3.7Patient Review
7/6/2011 Aldomet has been pretty effective in controlling my blood pressure, but the side effects are really tough to deal with. I'm hoping to find an alternative medication that won't be so debilitating.
3.7Patient Review
6/22/2009 I've been taking Aldomet for about 5 months. At first, I took 250mg once a day and it helped lower my blood pressure somewhat inconsistently. So then my doctor increased the dosage to 500mg twice a day. Now I'm constantly tired and dizzy, but my blood pressure is more consistent. Trying to conceive has been difficult while on this medication.
3.3Patient Review
10/18/2009 I switched to this drug over a year ago in preparation for conceiving. However, I had to add Procardia eventually to get my blood pressure under control. By the end of most days, I'm extremely tired and my legs are swollen.
3.3Patient Review
5/20/2009 I took aldomet while pregnant and had no side effects or problems. It worked very well for me.
3Patient Review
5/30/2014 While this medication does help to lower my blood pressure, I have been having some issues with my bladder. It feels like I need to go every ten minutes, which is really disruptive. This also happened when I tried taking Micardis without the water tablets. The doctor didn't believe me when I said it might be the medication, but I'm convinced that's what it is.
2.7Patient Review
10/5/2010 I've been on this medication for a while now, and it's not my favorite. My doctors prescribed it to me during pregnancy, and I'm still taking it 3 months after delivery. I don't like taking it while nursing, but the doctor says I don't have a choice.
2.3Patient Review
7/16/2008 Since being diagnosed with chronic hypertension 4 months ago, my blood pressure has been under control thanks to Aldomet (methyldopa). I haven't had any problems controlling my blood pressure since starting this medication, and it has helped me tremendously.
2.3Patient Review
11/23/2013 This medication helped to lower my blood pressure; however, I started experiencing anxiety and depression about a week after taking it. As a result, I am weaning myself off the medication.
1Patient Review
2/3/2010 Trying to conceive and extremely worried about the potential side effects of this medication. If anyone has any insight, please share!
1Patient Review
3/4/2008Patient Q&A Section about aldomet
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of Aldomet?
"There are some side effects to this medication, including dizziness, lightheadedness, drowsiness, headache, and a stuffy nose. These effects are more likely to occur when starting the medication or when the dosage is increased."
Answered by AI
Why is Aldomet used in pregnancy?
"Methyldopa is a medication used to lower blood pressure in pregnancy."
Answered by AI
What is the best time to take Aldomet?
"To use Aldomet Tablet, take it orally with or without food as directed by your doctor, typically 2 to 4 times daily. Start taking this medication or any new dose increase in the evening to lower the risk of side effects. Also, if the doses of this medication are not equal, take the larger dose at bedtime."
Answered by AI
What is Aldomet drug used for?
"Aldomet contains methyldopa, an active substance that belongs to a group of medicines called 'antihypertensives.' Methyldopa is changed inside your body to a natural substance that lowers blood pressure. Your doctor has prescribed Aldomet to treat high blood pressure (hypertension)."
Answered by AI