← Back to Search

Nonsteroidal Anti-inflammatory Drug

Low Dose Aspirin for Preeclampsia

Phase < 1
Recruiting
Research Sponsored by Anna Stanhewicz, PhD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Women who had preeclampsia and did not use LDA during pregnancy
18 years or older
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at the study visit, an average of 4 hours
Awards & highlights

Study Summary

This trial seeks to determine whether taking low dose aspirin (LDA) can reduce long-term risk of cardiovascular disease in women who had preeclampsia during pregnancy.

Who is the study for?
This trial is for women aged 18 or older who are 12 weeks to 5 years postpartum. It's suitable for those with a history of normal pregnancy or preeclampsia, regardless of low dose aspirin use during pregnancy. Women currently on daily aspirin, with skin diseases, tobacco use, certain chronic diseases like reduced kidney function, using cholesterol medications or antihypertensives, prior hypertension or gestational diabetes, current pregnancy, underweight BMI (<18.5), or allergies to study materials and drugs cannot participate.Check my eligibility
What is being tested?
The study investigates how low dose aspirin therapy affects blood vessel function after childbirth in women who had preeclampsia. Researchers will examine the microvascular function in the skin using intradermal microdialysis to deliver Acetylcholine and Endothelin-1 locally and analyze inflammatory cells from drawn blood.See study design
What are the potential side effects?
While not explicitly listed in the provided information, common side effects associated with similar procedures may include minor pain at injection sites, potential bruising or bleeding where blood is drawn; allergic reactions could occur if sensitivity to applied substances exists.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I had preeclampsia and did not take low-dose aspirin during my pregnancy.
Select...
I am 18 years old or older.
Select...
I had preeclampsia and took low-dose aspirin during my pregnancy.
Select...
I had a normal pregnancy without taking low dose aspirin.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at the study visit, an average of 4 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and at the study visit, an average of 4 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
microvascular endothelial function
microvascular endothelin-1-mediated constriction

Trial Design

1Treatment groups
Experimental Treatment
Group I: assessment of microvascular functionExperimental Treatment2 Interventions
The investigators use intradermal microdialysis to deliver acetylcholine, acetylcholine + L-NAME, endothelin-1, endothelin-1 + BQ-788, and endothelin-1 + BQ-123 to the cutaneous microvasculature.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Acetylcholine
2013
Completed Phase 2
~220
Endothelin-1
2008
N/A
~20

Find a Location

Who is running the clinical trial?

Anna Stanhewicz, PhDLead Sponsor
9 Previous Clinical Trials
320 Total Patients Enrolled

Media Library

Aspirin (Nonsteroidal Anti-inflammatory Drug) Clinical Trial Eligibility Overview. Trial Name: NCT05653973 — Phase < 1
Prophylaxis of Preeclampsia Research Study Groups: assessment of microvascular function
Prophylaxis of Preeclampsia Clinical Trial 2023: Aspirin Highlights & Side Effects. Trial Name: NCT05653973 — Phase < 1
Aspirin (Nonsteroidal Anti-inflammatory Drug) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05653973 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is it permissible to join this investigation if one is of an advanced age?

"The eligibility criteria for this research mandates that patients must be between 18 years and 50 years of age."

Answered by AI

Is enrollment in this research endeavor still available?

"The current status of this medical trial, which was initially listed on March 1st 2023, is actively recruiting. As per the latest update from April 24th 2023, it can be found on clinicaltrials.gov."

Answered by AI

How many participants is this study enrolling at present?

"Affirmative. According to the information located on clinicaltrials.gov, this study has been recruiting participants since its initial post date of March 1st 2023 and is currently seeking 60 people from one site."

Answered by AI

Would I meet the criteria to take part in this investigation?

"This clinical trial is enrolling sixty persons aged 18 to 50 with a prior history of preeclampsia. In addition, individuals must meet the following criteria: being eighteen years or older; having had a normal gestation and abstaining from taking low-dose aspirin (LDA) during pregnancy; experiencing skin diseases; using tobacco products; suffering from hepatic or metabolic disorders such as chronic kidney disease (CKD), characterized by an eGFR lower than 60 mL/min/1.73m2s; and currently engaging in daily intake of aspirin within 12 weeks up to five years after delivering their baby."

Answered by AI
~28 spots leftby Mar 2025