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Pomalidomide + Nivolumab for Viral Associated Cancers
Study Summary
This trial is testing a combination of two drugs to treat cancers caused by viruses. The drugs are pomalidomide and nivolumab, and the trial will test to see if they are safe and effective in treating these cancers.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2015 Phase 2 trial • 36 Patients • NCT02011113Trial Design
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Who is running the clinical trial?
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- I can take care of myself but might not be able to do heavy physical work.I do not have an autoimmune disease that needs strong immune system-suppressing drugs.My blood cancer can be measured or tracked.I have had immunotherapy before and did not experience severe side effects.I have had an organ or stem cell transplant from a donor.I haven't had cancer treatment in the last 2 weeks, or it was for a cancer that won't affect this trial.My cancer is caused by a virus, cannot be cured by surgery or other treatments, and has not responded to first treatments.I can take aspirin 81mg daily or a similar blood thinner.I still have side effects from previous cancer treatments.I am not pregnant or nursing, as the medication used in this study can be harmful.If you have a type of cancer that can be potentially cured with surgery, but you don't want to have the surgery because of how it might change your appearance or cause health issues, you may still be able to join the study if you understand and agree to the risks.My tumor type is eligible and has been tested for specific viral infections.I have another cancer type, but it won't affect this trial's treatment.My organs and bone marrow work well.I am not allergic to pomalidomide, nivolumab, or similar drugs.My liver disease is severe, with a Child-Pugh score of B or C.My brain cancer has not worsened after treatment.I am not on long-term steroids that can't be stopped, with some exceptions.Your pathology results need to be confirmed by the NCI Laboratory of Pathology for you to be eligible.I am 18 years old or older.My heart and lungs are healthy enough for treatment.My solid tumor can be measured by tests.
- Group 1: 1/Dose De-Escalation
- Group 2: 2/Dose Expansion
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What is the scope of enrolment for this clinical trial?
"Affirmative. The trial information hosted on clinicaltrials.gov affirms that this medical study, first introduced on December 10th 2021 is actively recruiting. 54 participants are required from a single site."
Has the Federal Drug Administration greenlighted Pomalidomide?
"The safety of Pomalidomide is graded at 1, as there exists limited data to support its efficacy and only preliminary studies have been conducted to understand its potential risks."
Is recruitment for this experiment still ongoing?
"Affirmative. Per the records on clinicaltrials.gov, enrollment for this medical trial is currently open. The experiment was first published online on December 10th 2021 and its most recent amendment took place on October 4th 2022. A total of 54 participants need to be recruited from 1 site in order to complete the study's aims."
Has Pomalidomide been previously explored in medical trials?
"Presently, there are 802 clinical trials that investigate the efficacy of Pomalidomide with 92 studies in its third phase. While Zürich, BE hosts many of these investigations, 43 042 sites worldwide have active research for this medication."
What indications is Pomalidomide traditionally employed to treat?
"Pomalidomide can be used to treat a variety of malignant tumours, including melanoma, squamous cell carcinoma, and metastatic esophageal adenocarcinoma."
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