Tegavivint for Wilms Tumor

"There was no single or definitive therapy for fibroma. The only treatment that has a high probability (≥ 85%) and acceptable chance of success was an excision. However, even this approach would have a high likelihood of recurrence, especially when the underlying disease was not detected. For this reason, excision should not be attempted unless the patient's age is less than 5 years and is in an early age. When excision fails, and despite the risk, a second excision would be an acceptable next step. However, the probability of recurrence is not negligible in fibroma, which would be particularly prevalent in patients diagnosed later in life and who do not have medical insurance that can cover their medical expenses." - Anonymous Online Contributor

"Fibroma is a malignant tumor of the lung that may occur in isolation or be associated with other lung diseases. It is most commonly found in women in the 30-50 group of age, has a tendency to grow in a central location in the chest, and usually responds well to anti-cancer chemotherapy and radiation techniques." - Anonymous Online Contributor

"The most successful case was of an 85-year-old woman, who is now in remission by using the treatment she used originally for [fibroma of the vulva in her history]. However, even then, the success rate of fibroma cure was not the same as the cure rate for [fibroma of the vulva], whose cure rate is 10-15%. Therefore, even though in cases of fibroma of the vulva, if it can be found early, the success rate of [fibroma cure is] lower and if found late, fibroma cannot cure." - Anonymous Online Contributor

"Numbness/tingling and a burning sensation are usually present in fibroma of the testis, while skin lesions may take the form of scaly, red papules that form on the scrotum. Scars form from testicular surgery and are often painful in the affected individual." - Anonymous Online Contributor

"The development of fibroma seems to involve a complex interaction between genetic and environmental risk factors that result in abnormal cell proliferation and differentiation. Fibroma also occurs in individuals with end-stage manifestations of rheumatoid arthritis, including osteophytes, extraosseous lesions and bone erosions. Osteophytes are a reliable and clinically apparent marker of long-standing subclinical, generalized bone disease even in rheumatoid individuals. Results from a recent clinical trial contributes to the identification of multiple and unique risks for the development of fibroma." - Anonymous Online Contributor

"around 400,000–500,000 people a year in the United States will be diagnosed with fibroma (benign fibrous tumour of the breast). Most cases occur on the right breast in females. The number of women and males with fibroma may be roughly equal. In an annual interval of 20 years there are expected to be 0.9 male-fibromas and 0.6 female-fibromas per 10,000 women between 35 and 75 years old in USA women. This means that, in an area of 20,000,000 women of 35–75 years old, there are expected 0.99 male-fibromas per 10,000 males (0." - Anonymous Online Contributor

"Fibroma progresses in young to mid-age women over years, more often with increasing body weight, and tends to progress to the extremities, retroperitoneum, or scrotum." - Anonymous Online Contributor

"The tumor typically arises along a superficial muscle or over a deep tendon sheath. The usual site of the tumor is on the back, but it can occur in other areas. Fibromas are a rare benign tumor; most people who have it are unaware that they have the disease." - Anonymous Online Contributor

"Results from a recent paper demonstrates that the use of TIV is associated with improved quality of life without overt side effects in patients with fibroma." - Anonymous Online Contributor

"Fibroma's natural history is unknown. Although some physicians feel the age of 20 may be the preferred time for Fibroma diagnosis due to its tendency to be diagnosed early in life, others feel fibroma is diagnosed at a greater age and is not recommended to postpone Fibroma for its treatment until later, while also pointing to the increased incidence of fibroma in females. The natural history and cause of Fibroma are not entirely clear; however, Fibroma is known to occur more often and on more males than females, and fibroma of males is thought to be related to an increased amount of testosterone." - Anonymous Online Contributor

"There have been two clinical trials involving tegavvir, both on subjects coinfected with HIV who received them in the context of ART. The first study involved treatment of 49 HIV-infected patients for 6 months with or with PIs. The HIV status of participants was generally unknown, and there were no significant toxicities reported. The second study involved 15 HIV-positive patients for 12 months, during which they had no antiretroviral drug use restrictions or required adherence monitoring. There were four patients with mild to moderate fatigue, none with nausea or vomiting. There were no significant changes in patient or study data in either trial. The FDA approved tegavir as a treatment, regardless of HIV status and ART-free status." - Anonymous Online Contributor

"The combination of TEGAVIVINT with chemotherapy is highly effective. Results from a recent paper of this study can be considered in the context of the current situation of oncological specialists in Afghanistan: the number of advanced cancers is too high that it is difficult to allocate all resources for anticancer therapies. Thus adjunctive therapies are the only way forward." - Anonymous Online Contributor