Lioresal
Chronic Pain, Clonus, severe spinal cord origin Spasticity + 11 more
Treatment
20 Active Studies for Lioresal
Treatment for
Chronic Pain
What is Lioresal
Baclofen
The Generic name of this drug
Treatment Summary
Baclofen is a muscle relaxer that is used to relieve painful or uncomfortable muscle spasms caused by certain medical conditions. It is often prescribed to people with spinal cord injuries to reduce muscle spasticity. There is currently not enough evidence to determine whether baclofen is effective in treating alcohol withdrawal. This drug was approved by the FDA in 1992.
Lioresal
is the brand name
Lioresal Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lioresal
Baclofen
1977
325
Effectiveness
How Lioresal Affects Patients
Baclofen is a drug that helps with muscle relaxation. It works by decreasing the amount of excitatory signals sent from pre-synaptic neurons and increasing the amount of inhibitory signals sent from post-synaptic neurons. Most commonly, it is taken orally. In one study, it was found to be more effective at reducing spasticity when given directly into the spinal cord than when taken orally. Baclofen can cause drowsiness, poor balance, slow breathing, and a decrease in heart rate. It also can help reduce pain and increase stomach acid production. Additionally, baclofen has anti-inflammatory
How Lioresal works in the body
Baclofen works by blocking signals between the brain and muscles. It binds to GABA receptors, which are found on both pre- and post-synaptic neurons. This blocks the action potentials which would normally be sent to the muscles, leading to relaxation of spasticity. It also causes an influx of potassium into the neuron, which further helps to relax the muscles. Baclofen may also act on some voltage-gated calcium channels, but the clinical significance of this is still unclear.
When to interrupt dosage
The measure of Lioresal is contingent upon the identified affliction, including Spasticity, Multiple Sclerosis and Joint Pain. The dosage is subject to the method of delivery (e.g. Injection - Intrathecal or Tablet - Oral) referenced in the table below.
Condition
Dosage
Administration
Muscle Spasticity
10.0 mg, 20.0 mg, , 0.05 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 4.0 mg/mL, 10.0 mg/mL, 25.0 mg, 5.0 mg, 1.0 mg/mg, 3.0 mg/mg, 5.0 mg/mL
Tablet, Tablet - Oral, , Oral, Kit - Topical, Kit, Topical, Solution, Intrathecal, Solution - Intrathecal, Injection, Injection - Intrathecal, Injection, solution, Injection, solution - Intrathecal, Cream - Topical, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Solution - Oral, Granule - Oral, Granule, Suspension, Suspension - Oral
Spinal Cord Diseases
10.0 mg, 20.0 mg, , 0.05 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 4.0 mg/mL, 10.0 mg/mL, 25.0 mg, 5.0 mg, 1.0 mg/mg, 3.0 mg/mg, 5.0 mg/mL
Tablet, Tablet - Oral, , Oral, Kit - Topical, Kit, Topical, Solution, Intrathecal, Solution - Intrathecal, Injection, Injection - Intrathecal, Injection, solution, Injection, solution - Intrathecal, Cream - Topical, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Solution - Oral, Granule - Oral, Granule, Suspension, Suspension - Oral
Multiple Sclerosis
10.0 mg, 20.0 mg, , 0.05 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 4.0 mg/mL, 10.0 mg/mL, 25.0 mg, 5.0 mg, 1.0 mg/mg, 3.0 mg/mg, 5.0 mg/mL
Tablet, Tablet - Oral, , Oral, Kit - Topical, Kit, Topical, Solution, Intrathecal, Solution - Intrathecal, Injection, Injection - Intrathecal, Injection, solution, Injection, solution - Intrathecal, Cream - Topical, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Solution - Oral, Granule - Oral, Granule, Suspension, Suspension - Oral
Clonus
10.0 mg, 20.0 mg, , 0.05 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 4.0 mg/mL, 10.0 mg/mL, 25.0 mg, 5.0 mg, 1.0 mg/mg, 3.0 mg/mg, 5.0 mg/mL
Tablet, Tablet - Oral, , Oral, Kit - Topical, Kit, Topical, Solution, Intrathecal, Solution - Intrathecal, Injection, Injection - Intrathecal, Injection, solution, Injection, solution - Intrathecal, Cream - Topical, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Solution - Oral, Granule - Oral, Granule, Suspension, Suspension - Oral
severe spinal cord origin Spasticity
10.0 mg, 20.0 mg, , 0.05 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 4.0 mg/mL, 10.0 mg/mL, 25.0 mg, 5.0 mg, 1.0 mg/mg, 3.0 mg/mg, 5.0 mg/mL
Tablet, Tablet - Oral, , Oral, Kit - Topical, Kit, Topical, Solution, Intrathecal, Solution - Intrathecal, Injection, Injection - Intrathecal, Injection, solution, Injection, solution - Intrathecal, Cream - Topical, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Solution - Oral, Granule - Oral, Granule, Suspension, Suspension - Oral
severe cerebral origin Spasticity
10.0 mg, 20.0 mg, , 0.05 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 4.0 mg/mL, 10.0 mg/mL, 25.0 mg, 5.0 mg, 1.0 mg/mg, 3.0 mg/mg, 5.0 mg/mL
Tablet, Tablet - Oral, , Oral, Kit - Topical, Kit, Topical, Solution, Intrathecal, Solution - Intrathecal, Injection, Injection - Intrathecal, Injection, solution, Injection, solution - Intrathecal, Cream - Topical, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Solution - Oral, Granule - Oral, Granule, Suspension, Suspension - Oral
Muscle Spasticity
10.0 mg, 20.0 mg, , 0.05 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 4.0 mg/mL, 10.0 mg/mL, 25.0 mg, 5.0 mg, 1.0 mg/mg, 3.0 mg/mg, 5.0 mg/mL
Tablet, Tablet - Oral, , Oral, Kit - Topical, Kit, Topical, Solution, Intrathecal, Solution - Intrathecal, Injection, Injection - Intrathecal, Injection, solution, Injection, solution - Intrathecal, Cream - Topical, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Solution - Oral, Granule - Oral, Granule, Suspension, Suspension - Oral
Spinal Cord Injury
10.0 mg, 20.0 mg, , 0.05 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 4.0 mg/mL, 10.0 mg/mL, 25.0 mg, 5.0 mg, 1.0 mg/mg, 3.0 mg/mg, 5.0 mg/mL
Tablet, Tablet - Oral, , Oral, Kit - Topical, Kit, Topical, Solution, Intrathecal, Solution - Intrathecal, Injection, Injection - Intrathecal, Injection, solution, Injection, solution - Intrathecal, Cream - Topical, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Solution - Oral, Granule - Oral, Granule, Suspension, Suspension - Oral
Cerebral Palsy
10.0 mg, 20.0 mg, , 0.05 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 4.0 mg/mL, 10.0 mg/mL, 25.0 mg, 5.0 mg, 1.0 mg/mg, 3.0 mg/mg, 5.0 mg/mL
Tablet, Tablet - Oral, , Oral, Kit - Topical, Kit, Topical, Solution, Intrathecal, Solution - Intrathecal, Injection, Injection - Intrathecal, Injection, solution, Injection, solution - Intrathecal, Cream - Topical, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Solution - Oral, Granule - Oral, Granule, Suspension, Suspension - Oral
Concussion
10.0 mg, 20.0 mg, , 0.05 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 4.0 mg/mL, 10.0 mg/mL, 25.0 mg, 5.0 mg, 1.0 mg/mg, 3.0 mg/mg, 5.0 mg/mL
Tablet, Tablet - Oral, , Oral, Kit - Topical, Kit, Topical, Solution, Intrathecal, Solution - Intrathecal, Injection, Injection - Intrathecal, Injection, solution, Injection, solution - Intrathecal, Cream - Topical, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Solution - Oral, Granule - Oral, Granule, Suspension, Suspension - Oral
Spasm
10.0 mg, 20.0 mg, , 0.05 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 4.0 mg/mL, 10.0 mg/mL, 25.0 mg, 5.0 mg, 1.0 mg/mg, 3.0 mg/mg, 5.0 mg/mL
Tablet, Tablet - Oral, , Oral, Kit - Topical, Kit, Topical, Solution, Intrathecal, Solution - Intrathecal, Injection, Injection - Intrathecal, Injection, solution, Injection, solution - Intrathecal, Cream - Topical, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Solution - Oral, Granule - Oral, Granule, Suspension, Suspension - Oral
Alcoholism
10.0 mg, 20.0 mg, , 0.05 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 4.0 mg/mL, 10.0 mg/mL, 25.0 mg, 5.0 mg, 1.0 mg/mg, 3.0 mg/mg, 5.0 mg/mL
Tablet, Tablet - Oral, , Oral, Kit - Topical, Kit, Topical, Solution, Intrathecal, Solution - Intrathecal, Injection, Injection - Intrathecal, Injection, solution, Injection, solution - Intrathecal, Cream - Topical, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Solution - Oral, Granule - Oral, Granule, Suspension, Suspension - Oral
Muscle Rigidity
10.0 mg, 20.0 mg, , 0.05 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 4.0 mg/mL, 10.0 mg/mL, 25.0 mg, 5.0 mg, 1.0 mg/mg, 3.0 mg/mg, 5.0 mg/mL
Tablet, Tablet - Oral, , Oral, Kit - Topical, Kit, Topical, Solution, Intrathecal, Solution - Intrathecal, Injection, Injection - Intrathecal, Injection, solution, Injection, solution - Intrathecal, Cream - Topical, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Solution - Oral, Granule - Oral, Granule, Suspension, Suspension - Oral
Chronic Pain
10.0 mg, 20.0 mg, , 0.05 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 4.0 mg/mL, 10.0 mg/mL, 25.0 mg, 5.0 mg, 1.0 mg/mg, 3.0 mg/mg, 5.0 mg/mL
Tablet, Tablet - Oral, , Oral, Kit - Topical, Kit, Topical, Solution, Intrathecal, Solution - Intrathecal, Injection, Injection - Intrathecal, Injection, solution, Injection, solution - Intrathecal, Cream - Topical, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Solution - Oral, Granule - Oral, Granule, Suspension, Suspension - Oral
Warnings
Lioresal Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Baclofen may interact with Pulse Frequency
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Lioresal.
Common Lioresal Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Baclofen may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Baclofen may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Baclofen is combined with Oliceridine.
Thalidomide
Major
Baclofen may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
1,2-Benzodiazepine
Minor
Baclofen may increase the central nervous system depressant (CNS depressant) activities of 1,2-Benzodiazepine.
Lioresal Toxicity & Overdose Risk
The lowest toxic dose of baclofen in rats is 145 mg/kg. Symptoms of a baclofen overdose may include confusion, sleepiness, low body temperature, shallow or slow breathing, coma, and seizures. Other rare symptoms can include changes in blood pressure, a slow or fast heartbeat, and vomiting. If someone has overdosed on baclofen, immediate medical attention should be sought. If the patient is awake, vomiting should be induced and their stomach contents should be removed. Unconscious patients should not be encouraged to vomit.
Lioresal Novel Uses: Which Conditions Have a Clinical Trial Featuring Lioresal?
451 active studies are currently investigating Lioresal's potential to reduce Clonus, Spasm and severe Spasticity of cerebral origin.
Condition
Clinical Trials
Trial Phases
Spinal Cord Injury
67 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Early Phase 1, Phase 1
Spinal Cord Diseases
10 Actively Recruiting
Not Applicable, Phase 2
Muscle Spasticity
0 Actively Recruiting
Alcoholism
7 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Concussion
92 Actively Recruiting
Not Applicable, Phase 2, Early Phase 1, Phase 3, Phase 1, Phase 4
Multiple Sclerosis
114 Actively Recruiting
Phase 3, Not Applicable, Phase 4, Phase 2, Phase 1, Early Phase 1
Cerebral Palsy
0 Actively Recruiting
Chronic Pain
122 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 3, Early Phase 1, Phase 1
severe spinal cord origin Spasticity
0 Actively Recruiting
severe cerebral origin Spasticity
0 Actively Recruiting
Muscle Spasticity
0 Actively Recruiting
Clonus
0 Actively Recruiting
Spasm
0 Actively Recruiting
Muscle Rigidity
0 Actively Recruiting
Lioresal Reviews: What are patients saying about Lioresal?
4.3
Patient Review
4/21/2009
Lioresal for Muscle Spasms caused by a Spinal Disease
4
Patient Review
9/23/2008
Lioresal for Muscle Spasms caused by a Spinal Disease
2.3
Patient Review
4/13/2010
Lioresal for Muscle Spasms caused by a Spinal Disease
2
Patient Review
1/1/2011
Lioresal for Abnormal Movements of Face Muscles and Tongue
1.3
Patient Review
10/19/2012
Lioresal for Muscle Spasms caused by a Spinal Disease
1
Patient Review
11/4/2012
Lioresal for Muscle Spasms caused by a Spinal Disease
Patient Q&A Section about lioresal
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Does Lioresal make you sleepy?
"This medicine can cause symptoms like dizziness, drowsiness, vision problems, or clumsiness in some people. Be sure to know how you'll react before doing anything that could be dangerous if you're not alert, coordinated, and able to see well."
Answered by AI
What class of drug is Lioresal?
"Baclofen is a drug that is used to relax muscles and reduce spasms. It is often prescribed for people who have multiple sclerosis or spinal cord injuries. Baclofen can help to relieve muscle pain, stiffness, and spasms."
Answered by AI
Are baclofen pain killers?
"No, Baclofen is not a pain killer. It is a muscle relaxer that can help with pain caused by muscle spasms, but will not help with other types of pain."
Answered by AI
What is Lioresal used to treat?
"Lioresal is a medication that helps to relieve spasticity of voluntary muscle that is a result of disorders such as multiple sclerosis, other spinal lesions, motor neurone disease, transverse myelitis, andtraumatic partial section of the cord."
Answered by AI