Gemfibrozil

Hyperlipidemia, Hyperlipidemia, Hyperlipidemia + 1 more

Treatment

7 FDA approvals

8 Active Studies for Gemfibrozil

Treatment for

Hyperlipidemia

What is Gemfibrozil

GemfibrozilThe Generic name of this drug

Treatment SummaryGemfibrozil is a type of medication that helps lower levels of fats in the blood. It is usually prescribed to people who have not seen improvements with diet, exercise and weight loss, as well as those with certain types of hyperlipidemias. Gemfibrozil was approved by the FDA in 1981.

Gemfibrozilis the brand name

image of different drug pills on a surface

Gemfibrozil Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Gemfibrozil

1993

128

Approved as Treatment by the FDA

Gemfibrozil, also known as Gemfibrozil, is approved by the FDA for 7 uses including Coronary Heart Disease (CHD) and Fredrickson classification type V Hyperlipidemia .

Coronary Heart Disease (CHD)

Fredrickson classification type V Hyperlipidemia

Helps manage Fredrickson classification type V Hyperlipidemia

Fredrickson classification type IV Hyperlipidemia

Helps manage Fredrickson classification type IV Hyperlipidemia

Coronary Heart Disease

Hyperlipidemia

Helps manage Fredrickson classification type V Hyperlipidemia

Hyperlipidemia

Helps manage Fredrickson classification type IV Hyperlipidemia

Effectiveness

How Gemfibrozil Affects PatientsGemfibrozil helps to control cholesterol levels in those with high cholesterol. It needs to be taken twice daily as it only lasts 9.6 hours in patients with kidney problems. It is generally considered safe, as trials with double the standard dose did not lead to serious side effects. However, there is a risk of gallstones or gallbladder inflammation for patients taking this drug, similar to those taking clofibrate.

How Gemfibrozil works in the bodyGemfibrozil works by activating a protein called PPARα, which affects how the body processes fats. This activation increases the amount of HDL (the good cholesterol), and decreases the amount of VLDL (the bad cholesterol). It also increases lipoprotein lipase, which helps to break down triglycerides in the blood. Gemfibrozil's metabolite also blocks an enzyme called CYP2C8, which helps further lower triglyceride levels.

When to interrupt dosage

The advised dose of Gemfibrozil is contingent upon the determined condition, including Hyperlipidemia, Hyperlipidemia and Coronary Heart Disease. The amount of dosage fluctuates, according to the technique of administration outlined in the table underneath.

Condition

Dosage

Administration

Hyperlipidemia

, 600.0 mg, 300.0 mg

, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral

Coronary Heart Disease

, 600.0 mg, 300.0 mg

, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral

Hyperlipidemia

, 600.0 mg, 300.0 mg

, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral

Hyperlipidemia

, 600.0 mg, 300.0 mg

, Oral, Tablet, coated, Tablet, coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral

Warnings

Gemfibrozil has nine contraindications, meaning it should not be taken while suffering from any of the conditions found in the following table.Gemfibrozil Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Liver Dysfunction

Do Not Combine

Pulse Frequency

Do Not Combine

Disease

Do Not Combine

Renal Insufficiency

Do Not Combine

Pulse Frequency

Do Not Combine

Liver Cirrhosis, Biliary

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Gemfibrozil may interact with Pulse Frequency

There are 20 known major drug interactions with Gemfibrozil.

Common Gemfibrozil Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Major

The metabolism of (R)-warfarin can be decreased when combined with Gemfibrozil.

(S)-Warfarin

Major

The metabolism of (S)-Warfarin can be decreased when combined with Gemfibrozil.

Abrocitinib

Major

The metabolism of Abrocitinib can be decreased when combined with Gemfibrozil.

Acenocoumarol

Major

The metabolism of Acenocoumarol can be decreased when combined with Gemfibrozil.

Acetohexamide

Major

The metabolism of Acetohexamide can be decreased when combined with Gemfibrozil.

Gemfibrozil Toxicity & Overdose RiskThe toxic dose of gemfibrozil for humans is 18gm/kg. The toxic dose in mice is 2218mg/kg and in rats is 1414mg/kg. If a person overdoses on gemfibrozil, they may experience abdominal cramps, abnormal liver function, diarrhea, increased CPK, joint and muscle pain, nausea, and vomiting. Treatment should involve supportive measures and symptom relief.

image of a doctor in a lab doing drug, clinical research

Gemfibrozil Novel Uses: Which Conditions Have a Clinical Trial Featuring Gemfibrozil?

Six active trials are presently being conducted to assess the potential of Gemfibrozil for mitigating Hyperlipidemia, Hyperlipidemia, and Hyperlipidemia-related conditions.

Condition

Clinical Trials

Trial Phases

Hyperlipidemia

0 Actively Recruiting

Hyperlipidemia

0 Actively Recruiting

Coronary Heart Disease

8 Actively Recruiting

Not Applicable, Early Phase 1

Hyperlipidemia

0 Actively Recruiting