Cholesterol Clinical Trials 2023
Browse 54 Cholesterol Medical Studies Across 274 Cities
12 Phase 3 Trial · 443 Cholesterol Clinics
What Are Cholesterol Clinical Trials?
The liver produces cholesterol, a waxy, fatty substance in the bloodstream and the body's cells. In addition to being necessary for forming tissues, hormones, bile acid, cell walls, and vitamin D, cholesterol is vital for staying healthy.
The two primary sources of cholesterol are the liver, and the remaining cholesterol in your body is obtained from animal-based diets, including lamb, poultry, and dairy products with dietary cholesterol. It is critical to study this entity, given the multitude of conditions connected to high cholesterol.
Therefore, researchers from prestigious academic institutions have been researching it through cholesterol clinical trials to raise diagnostic accuracy, aid in the diagnosis, and potentially provide treatments.
Why Is Cholesterol Being Studied Through Clinical Trials?
The total cholesterol levels in American adults 20 years of age and older are above 200 mg/dL (normal cholesterol levels are lower than 200mg/dl) in about 94 million people.
In the US, 28 million individuals report having overall cholesterol levels of more than 240 mg/dL. Almost 7% of American adolescents to teenagers between 6 and 19 have high cholesterol levels.
Even though cholesterol is required by the body to create healthy cells, high cholesterol levels significantly raise a person's risk of developing cardiovascular disease. An individual with high cholesterol faces the risk of accumulating fat in the coronary vascular system.
Over time, these fat deposits thicken and restrict the blood that can pass through the arteries. Therefore, it is crucial to conduct cholesterol clinical trials to aid in early detection, diagnosis, prevention, and treatment.
What Are The Types of Treatments Available For Cholesterol?
Cholesterol Absorption Inhibitors
The cholesterol consumed by an individual is absorbed by the small intestine and released into circulation. The medication Ezetimibe lowers blood cholesterol levels by preventing dietary cholesterol from being absorbed. Doctors often prescribe statins in conjunction with Ezetimibe.
Statins
Statins impede the production of the substance that is in charge of producing cholesterol in the liver. When one consumes statins, the liver begins to remove the cholesterol from the blood. There is a multitude of statins on the market, such as Pravachol (Zocor), Atorvastatin (Lipitor), Lovastatin (Altoprev), Rosuvastatin (Crestor), etc.
What Are Some Recent Breakthrough Clinical Trials For Cholesterol?
2021: Efficiency of Leqvio in lowering cholesterol- This study is based on Leqvio, a novel medication, which underwent three recent investigations evaluating its efficacy in treating high cholesterol. For some high-risk patients using statins, the research trials revealed a decrease of around 40% to 51% in LDL levels when Leqvio was administered to them.
2023: Efficiency of dietary supplements compared to statins- This study demonstrates that frequently utilized dietary supplements claimed to enhance heart health did not decrease bad cholesterol compared with a low dose of a cholesterol-lowering drug called a statin.
Who Are Some Of The Key Opinion Leaders / Researchers In Cholesterol Clinical Trial Research?
Dr. Paul Clift
Dr. Paul Clift is known for his role as the national specialty lead in cardiovascular disease for the NIHR. He specializes in cardiovascular disease, arrhythmias, and pulmonary arterial hypertension and has contributed to cholesterol clinical trials and conducted several studies on congenital cardiac disease.
Dr Endre Kiss Toth
Dr Endre Kiss Toth is a prominent postdoctoral lead_ _researcher at the University of Sheffield. He and other researchers at the University researched new methods of lowering cholesterol levels in the blood to prevent arteries from getting blocked due to fat buildup.
About The Author
Michael Gill - B. Sc.
First Published: October 13th, 2021
Last Reviewed: August 7th, 2023