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BMVP vs PRP for Meniscal Tears

Led By Aravind Athiviraham, MD
Research Sponsored by University of Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 16 or older
Loose body removal
Screening 3 weeks
Treatment Varies
Follow Up 1-year after meniscus tear operation.
Awards & highlights
No Placebo-Only Group

Study Summary

This trial will compare two methods of augmenting meniscal repairs to see which is more effective. The two methods are BMVP of the intercondylar notch and intra-articular PRP injections.

Who is the study for?
This trial is for individuals aged 16 or older with certain types of meniscal tears who haven't used cortisone, nicotine products, steroids, or immunosuppressants within specified time frames before surgery. It excludes those with ligament instability, immune compromise (like HIV), inflammatory diseases, undergoing certain knee procedures, non-English speakers, and those with a history of significant knee fractures.Check my eligibility
What is being tested?
The MVP Trial compares two biological treatments to enhance meniscal repair: Bone Marrow Venting Procedure (BMVP) and Platelet Rich Plasma (PRP) injections. The study aims to determine which method better prevents repair failure in patients with meniscal tears by tracking their recovery and need for reoperation.See study design
What are the potential side effects?
While the trial description does not specify side effects directly related to BMVP or PRP interventions being tested here, common risks may include pain at injection site, infection risk from the procedure itself, swelling or inflammation around the knee joint.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I am 16 years old or older.
I need surgery to remove loose fragments in my joint.
I am 16 years old or older.
I am only having minor knee procedures alongside my main treatment, or any other procedure has been approved.
I have a tear in my knee's cartilage.
I have had a synovectomy.
I have a tear in my knee's cartilage.
My tear type is mainly one that qualifies me for the study, as confirmed by a doctor.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1-year after meniscus tear operation.
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1-year after meniscus tear operation. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Promis Physical function CAT lower extremity score
Secondary outcome measures
Re-tear of repair meniscus

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Active Control
Group I: Platelet rich plasma (PRP)Active Control1 Intervention
Subjects randomized in the OR to undergo PRP surgical augmentation
Group II: Bone marrow venting procedure (BMVP)Active Control1 Intervention
Subjects randomized in the OR to undergo BMVP surgical augmentation

Find a Location

Who is running the clinical trial?

University of ChicagoLead Sponsor
988 Previous Clinical Trials
816,077 Total Patients Enrolled
American Orthopaedic Society for Sports MedicineOTHER
6 Previous Clinical Trials
1,111 Total Patients Enrolled
Aravind Athiviraham, MDPrincipal InvestigatorUniversity of Chicago

Media Library

Bone marrow venting procedure (BMVP) (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT04775004 — N/A
Meniscal Tear Research Study Groups: Platelet rich plasma (PRP), Bone marrow venting procedure (BMVP)
Meniscal Tear Clinical Trial 2023: Bone marrow venting procedure (BMVP) Highlights & Side Effects. Trial Name: NCT04775004 — N/A
Bone marrow venting procedure (BMVP) (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04775004 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies for participants in this trial?

"Affirmative, the clinicaltrials.gov page conveys that this research is actively enrolling participants. Firstly posted on July 19th 2021, and last updated a month ago - it seeks 146 individuals across 3 centres."

Answered by AI

How many participants are enrolling in this experimental program?

"Affirmative. According to the data hosted on clinicaltrials.gov, this trial which was initially posted on July 19th 2021 is still recruiting participants. A total of 146 patients are needed across 3 test sites."

Answered by AI

Who else is applying?

What state do they live in?
How old are they?
18 - 65
What site did they apply to?
University of Florida
What portion of applicants met pre-screening criteria?
Met criteria

How responsive is this trial?

Typically responds via
Most responsive sites:
  1. University of Florida: < 48 hours
Average response time
  • < 2 Days
~0 spots leftby Mar 2024