TAK-500 + Pembrolizumab for Advanced Solid Cancers
Trial Summary
What is the purpose of this trial?
This trial is testing a new drug called TAK-500, alone or with pembrolizumab, in adults with advanced or spreading solid tumors. The goal is to see if TAK-500 is safe and effective in shrinking these tumors.
Do I need to stop my current medications to join the trial?
The trial protocol does not specify if you need to stop your current medications. However, you cannot have had certain treatments like other STING agonists/antagonists, Toll-like receptor agonists, or CCR2 agonists/antagonists within the past 6 months. Also, you must not have received any investigational products or anticancer therapy within 14 days or 5 half-lives before starting the study drug. It's best to discuss your current medications with the study doctor.
What data supports the idea that TAK-500 + Pembrolizumab for Advanced Solid Cancers is an effective drug?
The available research shows that pembrolizumab, a part of the TAK-500 + Pembrolizumab combination, has been effective in treating certain types of cancer. For example, in patients with advanced non-small cell lung cancer, pembrolizumab improved survival rates compared to traditional chemotherapy. In one study, patients who received pembrolizumab lived longer and had a longer period before their cancer got worse compared to those who received chemotherapy. Additionally, pembrolizumab has shown benefits in treating advanced melanoma, where it improved survival and response rates compared to other treatments. These results suggest that pembrolizumab, when combined with TAK-500, could be an effective option for treating advanced solid cancers.12345
What safety data is available for TAK-500 and Pembrolizumab in treating advanced solid cancers?
Pembrolizumab, also known as KEYTRUDA or MK-3475, has been evaluated in various clinical trials for different cancers. Safety data from these trials indicate that common adverse reactions include fatigue, cough, nausea, pruritus, rash, decreased appetite, constipation, arthralgia, and diarrhea. Immune-mediated adverse reactions such as pneumonitis, colitis, hepatitis, hypophysitis, and thyroid disorders have also been reported. Pembrolizumab has shown clinical activity in solid tumors and is approved for certain cancers, but it can cause serious side effects like pneumonitis in 1%-5% of patients. There is no specific safety data provided for TAK-500 in the provided research.25678
Is the drug Pembrolizumab (also known as Keytruda or MK-3475) a promising treatment for advanced solid cancers?
Yes, Pembrolizumab is a promising drug for advanced solid cancers. It has been approved for treating various cancers, including endometrial carcinoma, non-small-cell lung cancer, melanoma, and esophageal cancer. It works by helping the immune system fight cancer cells, and studies have shown it can improve survival rates and response to treatment.245910
Research Team
Study Director
Principal Investigator
Takeda
Eligibility Criteria
Adults with certain advanced or metastatic solid tumors, including various cancers like lung, liver, breast, and stomach cancer. Participants must be in good physical condition (ECOG 0-1), have measurable disease per RECIST criteria, adequate organ function, and no severe side effects from previous treatments. They should not have heart issues or active hepatitis among other exclusions.Inclusion Criteria
Exclusion Criteria
Treatment Details
Interventions
- Pembrolizumab (Monoclonal Antibodies)
- TAK-500 (Other)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Takeda
Lead Sponsor