Lescol Xl

Hardening of the Arteries, Primary Hypercholesterolemia, Coronary Heart Disease + 5 more
Treatment
20 Active Studies for Lescol Xl

What is Lescol Xl

FluvastatinThe Generic name of this drug
Treatment SummaryFluvastatin is a medication used to lower cholesterol levels and reduce the risk of cardiovascular disease. It works by blocking an enzyme in the liver necessary for the production of cholesterol. Fluvastatin is a type of statin that is made up of equal amounts of two chemicals. It was the first artificial statin created and is different from other statins derived from fungi.
Lescolis the brand name
image of different drug pills on a surface
Lescol Xl Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lescol
Fluvastatin
1994
20

Effectiveness

How Lescol Xl Affects PatientsFluvastatin is a drug used to lower cholesterol and triglyceride levels, slow the progression of coronary atherosclerosis, and reduce the risk of needing coronary revascularization in patients with CHD. It is similar to other cholesterol-lowering drugs like lovastatin, simvastatin, and pravastatin, but has a shorter time period before it needs to be taken again, binds to proteins in the body, and does not pass into the spinal fluid. Fluvastatin works in the liver and comes in two forms, the 3R,5S form being the one that works best.
How Lescol Xl works in the bodyFluvastatin works to reduce cholesterol levels in the body. It does this by blocking an enzyme, HMG-CoA reductase, that plays a key role in producing cholesterol. When this enzyme is blocked, the liver is stimulated to make more LDL receptors, which help to clear out low-density lipoprotein (LDL) cholesterol from the bloodstream. This leads to lower levels of total and LDL cholesterol in the blood.

When to interrupt dosage

The prescribed dosage of Lescol Xl is contingent upon the determined condition, including unsuccessful dietary alteration, Coronary Heart Disease and Arteriosclerosis. The measure of dosage fluctuates, as per the method of administration laid out in the table beneath.
Condition
Dosage
Administration
Primary Hypercholesterolemia
, 80.0 mg, 20.0 mg, 40.0 mg
Oral, Tablet, extended release, Tablet, extended release - Oral, , Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Coronary Heart Disease
, 80.0 mg, 20.0 mg, 40.0 mg
Oral, Tablet, extended release, Tablet, extended release - Oral, , Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Dyslipidemias
, 80.0 mg, 20.0 mg, 40.0 mg
Oral, Tablet, extended release, Tablet, extended release - Oral, , Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
failed dietary modification
, 80.0 mg, 20.0 mg, 40.0 mg
Oral, Tablet, extended release, Tablet, extended release - Oral, , Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Interventional procedure
, 80.0 mg, 20.0 mg, 40.0 mg
Oral, Tablet, extended release, Tablet, extended release - Oral, , Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Hardening of the Arteries
, 80.0 mg, 20.0 mg, 40.0 mg
Oral, Tablet, extended release, Tablet, extended release - Oral, , Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Hypercholesterolemia
, 80.0 mg, 20.0 mg, 40.0 mg
Oral, Tablet, extended release, Tablet, extended release - Oral, , Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
1 year post-menarche
, 80.0 mg, 20.0 mg, 40.0 mg
Oral, Tablet, extended release, Tablet, extended release - Oral, , Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral

Warnings

Lescol Xl Contraindications
Condition
Risk Level
Notes
Transaminases
Do Not Combine
Liver Diseases
Do Not Combine
There are 20 known major drug interactions with Lescol Xl.
Common Lescol Xl Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Fluvastatin.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Fluvastatin.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Fluvastatin.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Fluvastatin.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Fluvastatin.
Lescol Xl Toxicity & Overdose RiskThe drug is usually well tolerated, but may cause digestive issues (diarrhea, nausea, constipation, gas, stomach pain), muscle damage (weakness, inflammation, breakdown of muscle tissue), and liver damage.
image of a doctor in a lab doing drug, clinical research

Lescol Xl Novel Uses: Which Conditions Have a Clinical Trial Featuring Lescol Xl?

64 active clinical trials are currently in progress to assess the efficacy of Lescol Xl in cases of failed dietary modification, post-menarcheal 1 year period, and Primary Hypercholesterolemia.
Condition
Clinical Trials
Trial Phases
Hardening of the Arteries
18 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Phase 3
Coronary Heart Disease
6 Actively Recruiting
Not Applicable, Early Phase 1
Primary Hypercholesterolemia
8 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Hypercholesterolemia
4 Actively Recruiting
Phase 1, Phase 3
Dyslipidemias
1 Actively Recruiting
Phase 2
1 year post-menarche
0 Actively Recruiting
failed dietary modification
0 Actively Recruiting
Interventional procedure
0 Actively Recruiting

Lescol Xl Reviews: What are patients saying about Lescol Xl?

5Patient Review
5/14/2008
Lescol Xl for High Cholesterol
After trying this medication for a few weeks, I ended up having really terrible reactions like muscle aches and pains. I also noticed that it caused other problems like organ damage. Overall, I would not recommend this drug because it did more harm than good.
5Patient Review
5/23/2009
Lescol Xl for High Cholesterol
I was on Lescol for a number of years with no side effects whatsoever. My cholesterol went from 300 to 168 in just one month. I had to be taken off Lipitor last week due to muscle weakness and high blood pressure, so hopefully Lescol will be covered again soon.
5Patient Review
2/21/2009
Lescol Xl for High Cholesterol
I took Lescol XL to lower my cholesterol. I started having the same problems as with Lipitor: severe muscle weakness, pain in joints and hair loss. I no longer take any form of statin.
5Patient Review
12/12/2008
Lescol Xl for High Cholesterol
I've been using this medication for years with no side effects. My numbers are all fine, but it is a bit of an expensive drug.
5Patient Review
11/6/2007
Lescol Xl for High Cholesterol
5Patient Review
4/23/2009
Lescol Xl for High Cholesterol
This treatment increased my appetite, which was a welcomed change.
4.7Patient Review
3/31/2008
Lescol Xl for High Cholesterol
Lescol XL was far more effective than other cholesterol medications I've tried, and it didn't come with any nasty side effects.
4.3Patient Review
4/9/2013
Lescol Xl for High Cholesterol
This medication was very effective in alleviating my muscle pain.
4Patient Review
3/23/2008
Lescol Xl for Combined High Blood Cholesterol and Triglyceride Level
While this medication has helped with my overall pain, I have found that it causes muscle weakness and fatigue.
3.3Patient Review
2/27/2011
Lescol Xl for Treatment to Prevent a Heart Attack
I experienced some really unpleasant headaches and muscle pain in my legs while taking this medication.
3Patient Review
1/26/2010
Lescol Xl for High Cholesterol
I appreciate that this statin uses a different binder than lacti acid, as I am intolerant to lactose.
2Patient Review
12/17/2007
Lescol Xl for High Cholesterol
I unfortunately experienced some intense muscle pain while using this treatment. It took a few weeks for the discomfort to dissipate even after I stopped using the medication.
2Patient Review
12/29/2007
Lescol Xl for Combined High Blood Cholesterol and Triglyceride Level
After developing muscle problems from Lipitor, I switched to Lescol. It's been much better for me-- no issues and my numbers look great.
2Patient Review
10/31/2007
Lescol Xl for Combined High Blood Cholesterol and Triglyceride Level
1.7Patient Review
10/11/2009
Lescol Xl for High Cholesterol
The cost of this medication is outrageous. I can't believe it's not generic yet.
1Patient Review
1/6/2008
Lescol Xl for High Cholesterol
After being on this medication for just four days, I've already experienced a long list of side effects: gas, diarrhea, itchiness and rash, sore sinuses, coughing, difficulty sleeping and some chest pain.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about lescol xl

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Lescol XL used for?

"Fluvastatin is used in conjunction with a proper diet to lower bad cholesterol and fats (such as LDL, triglycerides), and raise good cholesterol (HDL) in the blood. It's a drug in the statin class. It works by reducing the amount of cholesterol produced by the liver."

Answered by AI

When should I take Lescol XL?

"The recommended dose of fluvastatin for adults ranges from 20 to 80 milligrams (mg) per day. You can take up to 60 mg in a single dose in the evening or at bedtime. The 80-mg dose can be divided into two 40-mg capsules and taken twice a day with or after meals, or as a single 80-mg extended-release capsule taken once daily."

Answered by AI

Is Lescol XL still available?

"Is the generic version of fluvastatin still available? The brand name Lescol has been discontinued, but the extended-release version of fluvastatin is available in both generic and brand name (Lescol XL) form."

Answered by AI

What are the side effects of Lescol?

"Some potential side effects of taking ibuprofen include stomach pain, difficulty sleeping, headache, and diarrhea."

Answered by AI

Clinical Trials for Lescol Xl

Image of Metabolic & Atherosclerosis Research Center in Cincinnati, United States.

Lerodalcibep for High Cholesterol

6 - 17
All Sexes
Cincinnati, OH
The goal of this clinical trial is to assess the LDL-Cholesterol reductions at Week 12 and Week 24 with monthly dosing of lerodalcibep (Lerochol) 300 mg administered subcutaneously by auto-injector (AI)/pre-filled pen (PFP) compared to placebo (dummy), in male and female pediatric patients 6 to 17 years of age, with inherited high cholesterol (HeFH) on a stable diet and maximally tolerated oral LDL C lowering drug therapy such as statins. The main question\[s\] it aims to answer are: How effective is Lerochol in reducing LDL cholesterol? How well is it tolerated and are there any safety concerns? Researchers will compare Lerochol to placebo (inert or dummy injection solution). Participants will visit the clinic every month for months and be asked to fast overnight, but allowed to drink water, before clinic visits. Undergo physical exams, height and weight measurements, answer questions, have blood drawn from a vein in their arm, have blood pressure measurements, EKC heart tests, and receive monthly injections lasting about 5 seconds in their arms or abdomen with an autoinjector.
Phase 3
Waitlist Available
Metabolic & Atherosclerosis Research CenterDavid Kallend, MB BSLIB Therapeutics LLC
Image of Research Site in Chula Vista, United States.

AZD0780 for Hypercholesterolemia

18+
All Sexes
Chula Vista, CA
This is a study to evaluate the efficacy and safety of AZD0780 in adults with HeFH and elevated LDL-C, either with clinical ASCVD and LDL-C levels of 55 mg/dL or higher or without clinical ASCVD and LDL-C levels of 70 mg/dL or higher. AZD0780 is a small molecule that reduces the amount of LDL-C in the blood. Placebo will be used for comparison, and neither the participants nor the Investigators will know who is receiving the AZD0780 medication and who is receiving the placebo until the end of study. The total length of the study for an individual participant will be up to approximately 56 weeks, including a screening period of up to 14 days, treatment with AZD0780 or placebo for 52 weeks, and a safety follow-up period of 10 days.
Phase 3
Recruiting
Research Site (+28 Sites)AstraZeneca
Have you considered Lescol Xl clinical trials? We made a collection of clinical trials featuring Lescol Xl, we think they might fit your search criteria.Go to Trials
Image of University of Ottawa Heart Institute in Ottawa, Canada.

Exercise Training for Heart Disease

18+
Female
Ottawa, Canada
This study will compare the effects of two different types of training on exercise capacity in women with coronary heart disease (CHD). Participants will be randomized into either the virtual high-intensity interval training (HIIT) or the virtual moderate-to-vigorous intensity continuous training (MICT). After randomization, patients will exercise twice a week, for 12 weeks. The sessions will be conducted virtually. Patients will undergo a maximal exercise test, cardiometabolic indicators (height (cm), body mass (kg), body composition (%), waist circumference (cm) and, resting blood pressure) and complete questionnaires about quality of life, mental health, self-determined motivation, self-efficacy and enjoyment.
Waitlist Available
Has No Placebo
University of Ottawa Heart InstituteJennifer Reed, PhD
Image of Wake Forest University Health Sciences in Winston-Salem, United States.

Statins + Lifestyle Counseling for High Cholesterol

40 - 75
All Sexes
Winston-Salem, NC
Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders (EMERALD) is a protocolized intervention based on American College of Cardiology/American Heart Association and US Preventive Services Task Force guidelines designed to initiate preventive cardiovascular care for emergency department patients being evaluated for acute coronary syndrome. The overarching goals of this proposal are to (1) determine the efficacy of EMERALD at lowering low-density lipoprotein cholesterol (LDL-C) and non high-density lipoprotein cholesterol (non-HDL-C) among at-risk Emergency Department (ED) patients who are not already receiving guideline-directed outpatient preventive care and (2) inform our understanding of patient adherence and determinants of implementation for ED-based cardiovascular disease prevention strategies.
Phase 2
Recruiting
Wake Forest University Health SciencesNick Ashburn
Have you considered Lescol Xl clinical trials? We made a collection of clinical trials featuring Lescol Xl, we think they might fit your search criteria.Go to Trials
Image of West Virginia School of Osteopathic Medicine in Lewisburg, United States.

Lifestyle Interventions for Chronic Disease

18 - 64
All Sexes
Lewisburg, WV
Developed nations worldwide are currently enduring a health crisis, as chronic diseases continue to decrease quality of life and promote additional disease states or even death for much of the population. Rural populations are at a particular disadvantage, as they lack access to health clubs, wellness programs and similar resources that are more available in urban areas. Although pharmaceutical therapies have continued to show therapeutic advancements, the rates of disease onset and death from chronic disease has not seen similar improvements, and in fact continue to worsen. Excitingly, significant evidence has been published demonstrating an affordable, effective treatment to directly treat and prevent these chronic diseases, but few have demonstrated successful implementation of this therapy, which is improved lifestyle. Specifically, physical activity and healthy body composition are powerful therapeutics that have been demonstrated to effectively combat and prevent chronic diseases. Additionally, improving these lifestyle factors are often more effective than pharmaceutical interventions without the wide range of side effects. Unfortunately, barriers exist on multiple tiers in the practice of family medicine that demote the implementation of lifestyle medicine. To better serve patients at risk of, or suffering from chronic disease, the investigators are seeking to establish a lifestyle medicine prescription program for rural West Virginia. This program will provide patient education on the benefits of physical activity, body composition, and help patients identify strategies to implement healthy lifestyle choices that can be sustainable for the long-term. Patients will be advised on local opportunities to increase physical activity (yoga studio, martial arts, fitness facilities, aquatic center, etc.) and provided access to the facilities they are most likely to adhere to regularly. They will also be provided training on exercise techniques, equipment, and facilities to increase familiarity and comfort in these settings.
Recruiting
Has No Placebo
West Virginia School of Osteopathic MedicineChristopher L Pankey, Ph.D.
Have you considered Lescol Xl clinical trials? We made a collection of clinical trials featuring Lescol Xl, we think they might fit your search criteria.Go to Trials
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