Lescol Xl

Hardening of the Arteries, Primary Hypercholesterolemia, Coronary Heart Disease + 5 more
Treatment
20 Active Studies for Lescol Xl

What is Lescol Xl

FluvastatinThe Generic name of this drug
Treatment SummaryFluvastatin is a medication used to lower cholesterol levels and reduce the risk of cardiovascular disease. It works by blocking an enzyme in the liver necessary for the production of cholesterol. Fluvastatin is a type of statin that is made up of equal amounts of two chemicals. It was the first artificial statin created and is different from other statins derived from fungi.
Lescolis the brand name
image of different drug pills on a surface
Lescol Xl Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lescol
Fluvastatin
1994
20

Effectiveness

How Lescol Xl Affects PatientsFluvastatin is a drug used to lower cholesterol and triglyceride levels, slow the progression of coronary atherosclerosis, and reduce the risk of needing coronary revascularization in patients with CHD. It is similar to other cholesterol-lowering drugs like lovastatin, simvastatin, and pravastatin, but has a shorter time period before it needs to be taken again, binds to proteins in the body, and does not pass into the spinal fluid. Fluvastatin works in the liver and comes in two forms, the 3R,5S form being the one that works best.
How Lescol Xl works in the bodyFluvastatin works to reduce cholesterol levels in the body. It does this by blocking an enzyme, HMG-CoA reductase, that plays a key role in producing cholesterol. When this enzyme is blocked, the liver is stimulated to make more LDL receptors, which help to clear out low-density lipoprotein (LDL) cholesterol from the bloodstream. This leads to lower levels of total and LDL cholesterol in the blood.

When to interrupt dosage

The prescribed dosage of Lescol Xl is contingent upon the determined condition, including unsuccessful dietary alteration, Coronary Heart Disease and Arteriosclerosis. The measure of dosage fluctuates, as per the method of administration laid out in the table beneath.
Condition
Dosage
Administration
Coronary Heart Disease
, 80.0 mg, 20.0 mg, 40.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Interventional procedure
, 80.0 mg, 20.0 mg, 40.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Primary Hypercholesterolemia
, 80.0 mg, 20.0 mg, 40.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Hardening of the Arteries
, 80.0 mg, 20.0 mg, 40.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Dyslipidemias
, 80.0 mg, 20.0 mg, 40.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Hypercholesterolemia
, 80.0 mg, 20.0 mg, 40.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
1 year post-menarche
, 80.0 mg, 20.0 mg, 40.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
failed dietary modification
, 80.0 mg, 20.0 mg, 40.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral

Warnings

Lescol Xl Contraindications
Condition
Risk Level
Notes
Transaminases
Do Not Combine
active liver disease
Do Not Combine
There are 20 known major drug interactions with Lescol Xl.
Common Lescol Xl Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Fluvastatin.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Fluvastatin.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Fluvastatin.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Fluvastatin.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Fluvastatin.
Lescol Xl Toxicity & Overdose RiskThe drug is usually well tolerated, but may cause digestive issues (diarrhea, nausea, constipation, gas, stomach pain), muscle damage (weakness, inflammation, breakdown of muscle tissue), and liver damage.
image of a doctor in a lab doing drug, clinical research

Lescol Xl Novel Uses: Which Conditions Have a Clinical Trial Featuring Lescol Xl?

64 active clinical trials are currently in progress to assess the efficacy of Lescol Xl in cases of failed dietary modification, post-menarcheal 1 year period, and Primary Hypercholesterolemia.
Condition
Clinical Trials
Trial Phases
Primary Hypercholesterolemia
18 Actively Recruiting
Early Phase 1, Not Applicable, Phase 3, Phase 2
Dyslipidemias
1 Actively Recruiting
Phase 2
Hypercholesterolemia
2 Actively Recruiting
Phase 3, Not Applicable
failed dietary modification
0 Actively Recruiting
1 year post-menarche
0 Actively Recruiting
Interventional procedure
0 Actively Recruiting
Coronary Heart Disease
9 Actively Recruiting
Phase 3, Not Applicable, Phase 2
Hardening of the Arteries
40 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Phase 3, Early Phase 1

Lescol Xl Reviews: What are patients saying about Lescol Xl?

5Patient Review
5/14/2008
Lescol Xl for High Cholesterol
After trying this medication for a few weeks, I ended up having really terrible reactions like muscle aches and pains. I also noticed that it caused other problems like organ damage. Overall, I would not recommend this drug because it did more harm than good.
5Patient Review
5/23/2009
Lescol Xl for High Cholesterol
I was on Lescol for a number of years with no side effects whatsoever. My cholesterol went from 300 to 168 in just one month. I had to be taken off Lipitor last week due to muscle weakness and high blood pressure, so hopefully Lescol will be covered again soon.
5Patient Review
2/21/2009
Lescol Xl for High Cholesterol
I took Lescol XL to lower my cholesterol. I started having the same problems as with Lipitor: severe muscle weakness, pain in joints and hair loss. I no longer take any form of statin.
5Patient Review
12/12/2008
Lescol Xl for High Cholesterol
I've been using this medication for years with no side effects. My numbers are all fine, but it is a bit of an expensive drug.
5Patient Review
11/6/2007
Lescol Xl for High Cholesterol
5Patient Review
4/23/2009
Lescol Xl for High Cholesterol
This treatment increased my appetite, which was a welcomed change.
4.7Patient Review
3/31/2008
Lescol Xl for High Cholesterol
Lescol XL was far more effective than other cholesterol medications I've tried, and it didn't come with any nasty side effects.
4.3Patient Review
4/9/2013
Lescol Xl for High Cholesterol
This medication was very effective in alleviating my muscle pain.
4Patient Review
3/23/2008
Lescol Xl for Combined High Blood Cholesterol and Triglyceride Level
While this medication has helped with my overall pain, I have found that it causes muscle weakness and fatigue.
3.3Patient Review
2/27/2011
Lescol Xl for Treatment to Prevent a Heart Attack
I experienced some really unpleasant headaches and muscle pain in my legs while taking this medication.
3Patient Review
1/26/2010
Lescol Xl for High Cholesterol
I appreciate that this statin uses a different binder than lacti acid, as I am intolerant to lactose.
2Patient Review
12/17/2007
Lescol Xl for High Cholesterol
I unfortunately experienced some intense muscle pain while using this treatment. It took a few weeks for the discomfort to dissipate even after I stopped using the medication.
2Patient Review
12/29/2007
Lescol Xl for Combined High Blood Cholesterol and Triglyceride Level
After developing muscle problems from Lipitor, I switched to Lescol. It's been much better for me-- no issues and my numbers look great.
2Patient Review
10/31/2007
Lescol Xl for Combined High Blood Cholesterol and Triglyceride Level
1.7Patient Review
10/11/2009
Lescol Xl for High Cholesterol
The cost of this medication is outrageous. I can't believe it's not generic yet.
1Patient Review
1/6/2008
Lescol Xl for High Cholesterol
After being on this medication for just four days, I've already experienced a long list of side effects: gas, diarrhea, itchiness and rash, sore sinuses, coughing, difficulty sleeping and some chest pain.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about lescol xl

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Lescol XL used for?

"Fluvastatin is used in conjunction with a proper diet to lower bad cholesterol and fats (such as LDL, triglycerides), and raise good cholesterol (HDL) in the blood. It's a drug in the statin class. It works by reducing the amount of cholesterol produced by the liver."

Answered by AI

When should I take Lescol XL?

"The recommended dose of fluvastatin for adults ranges from 20 to 80 milligrams (mg) per day. You can take up to 60 mg in a single dose in the evening or at bedtime. The 80-mg dose can be divided into two 40-mg capsules and taken twice a day with or after meals, or as a single 80-mg extended-release capsule taken once daily."

Answered by AI

Is Lescol XL still available?

"Is the generic version of fluvastatin still available? The brand name Lescol has been discontinued, but the extended-release version of fluvastatin is available in both generic and brand name (Lescol XL) form."

Answered by AI

What are the side effects of Lescol?

"Some potential side effects of taking ibuprofen include stomach pain, difficulty sleeping, headache, and diarrhea."

Answered by AI

Clinical Trials for Lescol Xl

Have you considered Lescol Xl clinical trials? We made a collection of clinical trials featuring Lescol Xl, we think they might fit your search criteria.
Have you considered Lescol Xl clinical trials? We made a collection of clinical trials featuring Lescol Xl, we think they might fit your search criteria.
Have you considered Lescol Xl clinical trials? We made a collection of clinical trials featuring Lescol Xl, we think they might fit your search criteria.