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Procedure
PET/CT vs. Cardiac CT for Coronary Artery Disease (PET; CT Trial)
N/A
Recruiting
Led By Armin Zadeh, MD PhD MPH
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Referred for coronary CT angiography because of suspected coronary heart disease (CHD) with stable symptoms
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 60 days
Awards & highlights
PET; CT Trial Summary
This trial will assess coronary artery plaque in 33 patients with suspected CAD using 3 different imaging tests. Early detection facilitates prevention. #medicine #cardiology
Who is the study for?
This trial is for men and women over 18 who have stable symptoms suggesting coronary artery disease (CAD) and are referred for a coronary CT angiography. It's not suitable for pregnant individuals, those with severe obesity (BMI >40), a history of heart disease, atrial fibrillation, or any condition that could affect their participation as per the investigator.Check my eligibility
What is being tested?
The study compares two imaging methods to detect coronary atherosclerotic disease: PET/CT versus conventional and ultra-high-resolution cardiac CT. The goal is to determine which method better identifies CAD in patients showing symptoms suggestive of this condition.See study design
What are the potential side effects?
While the document does not specify side effects, generally PET/CT scans may cause discomfort from lying still during the test or reactions to contrast agents if used—like mild itching or rash. Cardiac CT scans carry minimal risks such as exposure to radiation.
PET; CT Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am referred for a heart scan due to stable heart disease symptoms.
PET; CT Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 60 days
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~60 days
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Correlation of atheroma volume [mm3]
Diagnostic accuracy of detecting coronary atherosclerosis
Side effects data
From 2020 Phase 1 & 2 trial • 88 Patients • NCT023389999%
White blood cell count decreased
9%
Upper respiratory tract infection
6%
Fatigue
6%
Alanine aminotransferase increased
5%
Nausea
5%
Pain in extremity
5%
Dizziness
4%
Viral upper respiratory tract infection
4%
Anaemia
4%
Cardiac murmur
4%
Weight increased
4%
Dysuria
4%
Abdominal distension
3%
Rhinitis allergic
3%
Gastritis
3%
Paraesthesia
3%
Headache
3%
Somnolence
3%
Dyspepsia
3%
Aspartate aminotransferase increased
3%
Micturition disorder
3%
Dyspnoea
3%
Wheezing
3%
Platelet count decreased
1%
Laryngeal inflammation
1%
Leukopenia
1%
Gastrooesophageal reflux disease
1%
Arthropod bite
1%
Lymphadenopathy
1%
Episcleritis
1%
Urinary tract infection
1%
Computerised tomogram coronary artery abnormal
1%
Pharyngitis
1%
Oedema peripheral
1%
Abdominal pain
1%
Fall
1%
Vaginal infection
1%
Gastritis viral
1%
Frequent bowel movements
1%
Numbness
1%
Blood bicarbonate decreased
1%
Myalgia
1%
Fluid retention
1%
Decreased appetite
1%
Weight decreased
1%
Memory impairment
1%
Computerised tomogram abnormal
1%
Anorexia nervosa
1%
Hypertriglyceridaemia
1%
Vomiting
1%
Biopsy lymph gland
1%
Muscle spasms
1%
Disturbance in attention
1%
Blood creatinine increased
1%
Insomnia
1%
Panic attack
1%
Hot flush
1%
Lacrimation increased
1%
Constipation
1%
Diarrhoea
1%
Dysphagia
1%
Influenza like illness
1%
Localised oedema
1%
Herpes zoster
1%
Sinusitis
1%
Increased appetite
1%
Chills
1%
Galactorrhoea
1%
Cough
1%
Pain of Skin
1%
Pruritus
1%
Thyroid mass
1%
Helicobacter test positive
1%
Lymphocyte count decreased
1%
Neutrophil count decreased
100%
80%
60%
40%
20%
0%
Study treatment Arm
Pioglitazone
Placebo
PET; CT Trial Design
1Treatment groups
Experimental Treatment
Group I: Main groupExperimental Treatment1 Intervention
All patients undergo both, experimental and standard, tests
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
PET/CT
2022
Completed Phase 3
~1240
Find a Location
Who is running the clinical trial?
Johns Hopkins UniversityLead Sponsor
2,266 Previous Clinical Trials
14,837,464 Total Patients Enrolled
27 Trials studying Coronary Artery Disease
56,546 Patients Enrolled for Coronary Artery Disease
Armin Zadeh, MD PhD MPHPrincipal InvestigatorJohns Hopkins School of Medicine
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am referred for a heart scan due to stable heart disease symptoms.I have had a heart attack or surgery to improve blood flow to my heart.I have atrial fibrillation.My BMI is over 40, indicating morbid obesity.I am 18 years old or older.
Research Study Groups:
This trial has the following groups:- Group 1: Main group
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How many participants are enrolled in this experiment?
"Affirmative. Clinicaltrials.gov reveals that this experiment is now recruiting patients, with the first post date being July 1st 2023 and most recent update on August 8th 2023. The trial requires 33 participants from a single research centre to complete it."
Answered by AI
Is recruitment for this research still open?
"Indeed, records hosted on clinicaltrials.gov demonstrate that this medical experiment is currently welcoming applicants. Originally posted on July 1st 2023 and last modified August 8th 2023 , 33 participants are needed from a single research location."
Answered by AI
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