Voriconazole

Histoplasmosis, Candidemia, Coccidioidomycosis + 24 more
Treatment
13 FDA approvals
20 Active Studies for Voriconazole

What is Voriconazole

VoriconazoleThe Generic name of this drug
Treatment SummaryVoriconazole is an antifungal medication used to treat serious fungal infections in immunocompromised people. It is used to treat invasive candidiasis, invasive aspergillosis, and other emerging fungal infections. Voriconazole is also effective against some fungi that are resistant to other antifungal medications. It was approved by the FDA in 2002 under the trade name Vfend.
Voriconazoleis the brand name
image of different drug pills on a surface
Voriconazole Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Voriconazole
Voriconazole
2002
85

Approved as Treatment by the FDA

Voriconazole, also known as Voriconazole, is approved by the FDA for 13 uses like Esophageal Candidiasis and Systemic candidiasis .
Esophageal Candidiasis
Systemic candidiasis
refractory Fungal Infections
Scedosporium Infection
Invasive Aspergillosis
Hematopoietic stem cells
Neutropenia
Neuroaspergillosis
Candida (fungus)
prophylaxis of moderate Pneumocystis pneumonia
Candidemia
Fusariosis
Mycoses

Effectiveness

How Voriconazole Affects PatientsVoriconazole is a medication used to stop fungus from growing. It can cause liver and sun sensitivity issues in some people.
How Voriconazole works in the bodyVoriconazole is a medication used to treat fungal infections caused by organisms such as _Aspergillus spp._ and _Candida spp_. Voriconazole works by blocking a key enzyme called 14-alpha sterol demethylase. This enzyme is necessary for fungi to produce a type of fat called ergosterol, which is essential for cell membrane function. By blocking the production of ergosterol, voriconazole limits fungal cell growth and allows the body's immune system to clear the infection.

When to interrupt dosage

The proposed dosage of Voriconazole is contingent upon the diagnosed condition, including Esophageal Candidiasis, Meningitis, Fungal and Immunosuppression. The degree of measure varies as per the procedure of delivery (e.g. Tablet or Oral) outlined in the table below.
Condition
Dosage
Administration
Aspergillosis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Meningitis, Fungal
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Peritonitis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
prophylaxis of moderate Pneumocystis pneumonia
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Aspergillosis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Penicillium marneffei infection
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Debridement
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Lung Transplant
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Hematopoietic stem cells
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Candidemia
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Fusariosis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Aspergillosis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Histoplasmosis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Coccidioidomycosis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Neutropenia
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Immunosuppression
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Esophageal Candidiasis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Yeast Infection
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Candida (fungus)
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
aspergillus endophthalmitis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal

Warnings

Voriconazole Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Voriconazole may interact with Pulse Frequency
There are 20 known major drug interactions with Voriconazole.
Common Voriconazole Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Voriconazole.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Voriconazole.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Voriconazole.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Voriconazole.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Voriconazole.
Voriconazole Toxicity & Overdose RiskOverdosing on Voriconazole can cause sensitivity to light and a lengthened QT interval. If someone overdoses, it is recommended to provide supportive care and monitor their heart activity. Activated charcoal can help remove unabsorbed drug from the body, and hemodialysis can be used to remove absorbed drug at a rate of 121 mL/min. Studies have found that taking high doses of Voriconazole can lead to liver cancer in rats and mice.
image of a doctor in a lab doing drug, clinical research

Voriconazole Novel Uses: Which Conditions Have a Clinical Trial Featuring Voriconazole?

31 active clinical trials are currently underway to investigate the potential of Voriconazole to address Aspergillosis, Aspergillosis and Penicillium marneffei infection.
Condition
Clinical Trials
Trial Phases
Penicillium marneffei infection
0 Actively Recruiting
Esophageal Candidiasis
0 Actively Recruiting
Osteomyelitis
0 Actively Recruiting
Fusariosis
0 Actively Recruiting
Neutropenia
6 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3
Immunosuppression
9 Actively Recruiting
Phase 2, Phase 4, Not Applicable, Phase 3, Early Phase 1
Aspergillosis
2 Actively Recruiting
Phase 3
Candida (fungus)
0 Actively Recruiting
Histoplasmosis
0 Actively Recruiting
Mycoses
0 Actively Recruiting
Aspergillosis
0 Actively Recruiting
Neuroaspergillosis
0 Actively Recruiting
refractory Oral Candidiasis
0 Actively Recruiting
Lung Transplant
18 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1
Candidemia
3 Actively Recruiting
Phase 3, Phase 2
Peritonitis
0 Actively Recruiting
Meningitis, Fungal
0 Actively Recruiting
Debridement
0 Actively Recruiting
Yeast Infection
0 Actively Recruiting
Valve Replacement
0 Actively Recruiting

Voriconazole Reviews: What are patients saying about Voriconazole?

5Patient Review
10/29/2014
Voriconazole for Aggressive Fungal Infection - Invasive Aspergillosis
I'm very photosensitive, so this summer I made sure to get a good tan. Even with that protection, I still can't seem to get my dosage high enough to where it's therapeutic. I'm also working on shrinking a fungal infection in my lungs.
5Patient Review
4/2/2019
Voriconazole for A Fungal Infection - Aspergillosis
Voriconazole has been a lifesaver for me. I'm 60 now and it's kept the fungal infection at bay for years. Recently, I've also started to get skin cancer on my face and ears. So, during the summer months, I have to make sure to wear a wide-brimmed hat when I go outside.
4.7Patient Review
12/20/2011
Voriconazole for Aggressive Fungal Infection - Invasive Aspergillosis
I saw significant improvements in my asthma symptoms after just one week of using this medication. I was struggling for two years before they found the root cause (fungus in my lungs) but now I feel like a normal person again.
3Patient Review
11/11/2022
Voriconazole for Fungal Infection of the Esophagus
I used this treatment for thirteen days to treat a stubborn candida infection. I lost half of my hair during that time, and I'm still losing it one month later. There were also some vision-related side effects, but they're gone now. The candida symptoms returned two days after stopping the treatment. Although the vaginal yeast feels a little bit better, it's still painful and tests positive.
2.7Patient Review
5/4/2012
Voriconazole for Aggressive Fungal Infection - Invasive Aspergillosis
V-fend has been successful in treating my ABPA, but I have developed more severe allergic reactions each time. This last reaction could have been fatal if I hadn't stopped taking the medication.
View All Reviews
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Patient Q&A Section about voriconazole

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is voriconazole an antibiotic?

"Voriconazole is used to treat fungal infections. It stops the growth of fungi."

Answered by AI

How long do you take voriconazole?

"The length of time that you will have to take Vfend (voriconazole) will vary depending on the severity of your infection. Some people may need to take this medication for several months."

Answered by AI

Which is better fluconazole or voriconazole?

"At the end of the study, the researchers found that voriconazole was just as good as fluconazole at treating esophageal candidiasis."

Answered by AI

What are the side effects of voriconazole?

"The most commonly reported side effects of voriconazole are blurred vision, changes in vision color, visual disturbance, and enhanced visual perception. Other side effects include fever, nausea, skin rash, vomiting, and chills."

Answered by AI

Clinical Trials for Voriconazole

Have you considered Voriconazole clinical trials? We made a collection of clinical trials featuring Voriconazole, we think they might fit your search criteria.
Have you considered Voriconazole clinical trials? We made a collection of clinical trials featuring Voriconazole, we think they might fit your search criteria.
Have you considered Voriconazole clinical trials? We made a collection of clinical trials featuring Voriconazole, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
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