What is Voriconazole
VoriconazoleThe Generic name of this drug
Treatment SummaryVoriconazole is an antifungal medication used to treat serious fungal infections in immunocompromised people. It is used to treat invasive candidiasis, invasive aspergillosis, and other emerging fungal infections. Voriconazole is also effective against some fungi that are resistant to other antifungal medications. It was approved by the FDA in 2002 under the trade name Vfend.
Voriconazoleis the brand name
Voriconazole Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Voriconazole
Voriconazole
2002
85
Approved as Treatment by the FDA
Voriconazole, also known as Voriconazole, is approved by the FDA for 10 uses like prophylaxis of moderate Pneumocystis pneumonia and Neutropenia .prophylaxis of moderate Pneumocystis pneumonia
Neutropenia
Esophageal Candidiasis
Invasive Aspergillosis
Candida (fungus)
refractory Fungal Infections
Scedosporium Infection
Candidemia
Hematopoietic stem cells
Fusariosis
Effectiveness
How Voriconazole Affects PatientsVoriconazole is a medication used to stop fungus from growing. It can cause liver and sun sensitivity issues in some people.
How Voriconazole works in the bodyVoriconazole is a medication used to treat fungal infections caused by organisms such as _Aspergillus spp._ and _Candida spp_. Voriconazole works by blocking a key enzyme called 14-alpha sterol demethylase. This enzyme is necessary for fungi to produce a type of fat called ergosterol, which is essential for cell membrane function. By blocking the production of ergosterol, voriconazole limits fungal cell growth and allows the body's immune system to clear the infection.
When to interrupt dosage
The proposed dosage of Voriconazole is contingent upon the diagnosed condition, including Esophageal Candidiasis, Meningitis, Fungal and Immunosuppression. The degree of measure varies as per the procedure of delivery (e.g. Tablet or Oral) outlined in the table below.Condition
Dosage
Administration
Histoplasmosis
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
Fusariosis
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
Candida (fungus)
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
Aspergillosis
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
Penicillium marneffei infection
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
Valve Replacement
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
Lung Transplant
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
Meningitis, Fungal
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
Invasive Aspergillosis
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
refractory Fungal Infections
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
Infections, Fungal
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
Peritonitis
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
refractory Oral Candidiasis
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
Coccidioidomycosis
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
Immunosuppression
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
prophylaxis of moderate Pneumocystis pneumonia
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
Hematopoietic stem cells
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
Debridement
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
Scedosporium Infection
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
Esophageal Candidiasis
, 50.0 mg, 200.0 mg, 200.0 mg/mL, 10.0 mg/mL, 10.0 mg, 40.0 mg/mL
Tablet, Oral, , Suspension, Powder, for solution, Tablet, film coated, Tablet - Oral, Powder, for suspension, Injection, powder, for solution, Powder, Tablet, film coated - Nasal, Tablet, film coated - Oral, Tablet, coated, Injection, powder, lyophilized, for solution, Injection, powder, for solution - Intravenous, Intravenous, Suspension - Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Powder, for suspension - Oral, Powder - Intravenous, Tablet, coated - Oral, Nasal
Warnings
Voriconazole ContraindicationsCondition
Risk Level
Notes
Anus Diseases
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Voriconazole may interact with Toxoplasma Infections
Common Voriconazole Drug Interactions
Drug Name
Risk Level
Description
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Voriconazole.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Voriconazole.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be decreased when combined with Voriconazole.
7-ethyl-10-hydroxycamptothecin
Major
The metabolism of 7-ethyl-10-hydroxycamptothecin can be decreased when combined with Voriconazole.
9-aminocamptothecin
Major
The metabolism of 9-aminocamptothecin can be decreased when combined with Voriconazole.
Voriconazole Toxicity & Overdose RiskOverdosing on Voriconazole can cause sensitivity to light and a lengthened QT interval. If someone overdoses, it is recommended to provide supportive care and monitor their heart activity. Activated charcoal can help remove unabsorbed drug from the body, and hemodialysis can be used to remove absorbed drug at a rate of 121 mL/min. Studies have found that taking high doses of Voriconazole can lead to liver cancer in rats and mice.
Voriconazole Novel Uses: Which Conditions Have a Clinical Trial Featuring Voriconazole?
31 active clinical trials are currently underway to investigate the potential of Voriconazole to address Aspergillosis, Aspergillosis and Penicillium marneffei infection.Condition
Clinical Trials
Trial Phases
Meningitis, Fungal
0 Actively Recruiting
Scedosporium Infection
0 Actively Recruiting
Aspergillosis
0 Actively Recruiting
Lung Transplant
15 Actively Recruiting
Not Applicable, Early Phase 1, Phase 2
Penicillium marneffei infection
0 Actively Recruiting
aspergillus endophthalmitis
0 Actively Recruiting
Candidemia
4 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Hematopoietic stem cells
3 Actively Recruiting
Early Phase 1, Phase 1, Phase 2
Immunosuppression
9 Actively Recruiting
Phase 2, Phase 3, Phase 1, Not Applicable
prophylaxis of moderate Pneumocystis pneumonia
0 Actively Recruiting
Infections, Fungal
1 Actively Recruiting
Phase 3
Neutropenia
14 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4
Valve Replacement
0 Actively Recruiting
Candida (fungus)
0 Actively Recruiting
Histoplasmosis
1 Actively Recruiting
Phase 1, Phase 2
refractory Oral Candidiasis
0 Actively Recruiting
Peritonitis
0 Actively Recruiting
refractory Fungal Infections
0 Actively Recruiting
Debridement
0 Actively Recruiting
Esophageal Candidiasis
0 Actively Recruiting
Voriconazole Reviews: What are patients saying about Voriconazole?
5Patient Review
10/29/2014 I'm very photosensitive, so this summer I made sure to get a good tan. Even with that protection, I still can't seem to get my dosage high enough to where it's therapeutic. I'm also working on shrinking a fungal infection in my lungs.
5Patient Review
4/2/2019 Voriconazole has been a lifesaver for me. I'm 60 now and it's kept the fungal infection at bay for years. Recently, I've also started to get skin cancer on my face and ears. So, during the summer months, I have to make sure to wear a wide-brimmed hat when I go outside.
4.7Patient Review
12/20/2011 I saw significant improvements in my asthma symptoms after just one week of using this medication. I was struggling for two years before they found the root cause (fungus in my lungs) but now I feel like a normal person again.
3Patient Review
11/11/2022 I used this treatment for thirteen days to treat a stubborn candida infection. I lost half of my hair during that time, and I'm still losing it one month later. There were also some vision-related side effects, but they're gone now. The candida symptoms returned two days after stopping the treatment. Although the vaginal yeast feels a little bit better, it's still painful and tests positive.
2.7Patient Review
5/4/2012 V-fend has been successful in treating my ABPA, but I have developed more severe allergic reactions each time. This last reaction could have been fatal if I hadn't stopped taking the medication.
2.3Patient Review
9/18/2010 I had some really intense hallucinations while on this medication. I was also extremely irritable and saw things that weren't actually there. It was a scary experience for both me and the people around me.
2.3Patient Review
2/5/2012 I have been having severe gastrointestinal issues since taking this medication. My joints and muscles hurt, and now my face, throat, and stomach are swelling severely . I look like I've gained a lot of weight in a short amount of time.
Patient Q&A Section about voriconazole
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is voriconazole an antibiotic?
"Voriconazole is used to treat fungal infections. It stops the growth of fungi."
Answered by AI
How long do you take voriconazole?
"The length of time that you will have to take Vfend (voriconazole) will vary depending on the severity of your infection. Some people may need to take this medication for several months."
Answered by AI
Which is better fluconazole or voriconazole?
"At the end of the study, the researchers found that voriconazole was just as good as fluconazole at treating esophageal candidiasis."
Answered by AI
What are the side effects of voriconazole?
"The most commonly reported side effects of voriconazole are blurred vision, changes in vision color, visual disturbance, and enhanced visual perception. Other side effects include fever, nausea, skin rash, vomiting, and chills."
Answered by AI