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Procedure

Pulsatile blood flow for Acute Kidney Injury

N/A

Waitlist Available

Led By Nathan J Clendenen, MD, MS

Research Sponsored by University of Colorado, Denver

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up from intensive care unit admission after surgery to hospital discharge, up to 30 days

Awards & highlights

Study Summary

This trial aims to see if using a specific type of blood flow during heart surgery can help reduce the risk of kidney damage. Researchers will also look at how safe and effective this method is compared to the

Who is the study for?

This trial is for patients undergoing cardiac surgery who will be on cardiopulmonary bypass. It's not clear what specific conditions or characteristics make someone eligible or ineligible to participate.Check my eligibility

What is being tested?

The study is testing if pulsatile blood flow (mimicking natural heartbeat rhythms) during cardiopulmonary bypass can reduce kidney damage after heart surgery, compared to non-pulsatile flow (steady stream).See study design

What are the potential side effects?

Potential side effects are not specified, but may include complications related to changes in blood flow during surgery such as increased risk of bleeding, clotting issues, or other impacts on organ function.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ from intensive care unit admission after surgery to hospital discharge, up to 30 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~from intensive care unit admission after surgery to hospital discharge, up to 30 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and from intensive care unit admission after surgery to hospital discharge, up to 30 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Acute kidney injury

Secondary outcome measures

30-day mortality

Acute kidney injury risk score

Discontinuation rate of cardiopulmonary bypass mode

+2 more

Other outcome measures

Duration of mechanical ventilation

Intra-operative cryoprecipitate transfusion in units

Intra-operative plasma transfusion in units

+18 more

Trial Design

2Treatment groups

Active Control

Group I: Pulsatile blood flowActive Control1 Intervention

Pulsatile blood flow during cardiopulmonary bypass

Group II: Non-pulsatile blood flowActive Control1 Intervention

Non-pulsatile blood flow during cardiopulmonary bypass

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of Colorado, DenverLead Sponsor

1,739 Previous Clinical Trials

2,149,045 Total Patients Enrolled

7 Trials studying Acute Kidney Injury

439 Patients Enrolled for Acute Kidney Injury

National Heart, Lung, and Blood Institute (NHLBI)NIH

3,841 Previous Clinical Trials

47,813,005 Total Patients Enrolled

9 Trials studying Acute Kidney Injury

3,446 Patients Enrolled for Acute Kidney Injury

Nathan J Clendenen, MD, MSPrincipal InvestigatorUniversity of Colorado, Denver

1 Previous Clinical Trials

66 Total Patients Enrolled

1 Trials studying Acute Kidney Injury

66 Patients Enrolled for Acute Kidney Injury

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Do individuals aged 55 and above meet the criteria for participation in this medical study?

"Enrollment for this research study is open to individuals over 18 years old and under the age of 85."

Answered by AI

Are there any available openings for patients to participate in this medical study?

"Per the details on clinicaltrials.gov, this specific study is not presently accepting applicants. It was initially listed on 4/1/2024 and last revised on 4/4/2024. Despite its current inactivity, it's worth noting that there are currently 1302 other trials actively seeking participants."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury

2024. "Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06349577.

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