Verelan Pm
Cluster Headache, prophylaxis of Cluster headaches, Angina, Unstable + 7 more
Treatment
3 FDA approvals
20 Active Studies for Verelan Pm
Treatment for
Cluster Headache
What is Verelan Pm
Verapamil
The Generic name of this drug
Treatment Summary
Verapamil is a type of medication used to treat high blood pressure, irregular heartbeats, and chest pain. It was the first medication of its kind to be introduced in the 1960s and belongs to a group of medications called calcium channel blockers, which includes drugs like diltiazem and flunarizine. Verapamil comes in two forms: the S-enantiomer and the R-enantiomer, with the S-enantiomer being more powerful but also metabolized faster.
Calan
is the brand name
Verelan Pm Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Calan
Verapamil
1984
357
Approved as Treatment by the FDA
Verapamil, also called Calan, is approved by the FDA for 3 uses which include Atrial Fibrillation or Flutter and Hypertensive disease .
Atrial Fibrillation or Flutter
Used to treat Atrial Fibrillation or Flutter in combination with Digitoxin
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Trandolapril
Heart Rate
Used to treat Heart Rate in combination with Digitoxin
Effectiveness
How Verelan Pm Affects Patients
Verapamil is a drug used to treat heart rhythm problems, chest pain, and high blood pressure. It blocks a certain type of calcium channel in the body, which helps to regulate these conditions. Immediate-release versions must be taken 3 or 4 times a day, but there are extended-release forms that can be taken once a day. Those with severe heart problems should not take verapamil, as it can make these conditions worse.
How Verelan Pm works in the body
Verapamil works by blocking L-type calcium channels. These channels are found in the muscle tissue that makes up the heart and blood vessels, and they help control how much calcium flows into the cells. By blocking these channels, verapamil reduces the amount of calcium that can enter the cells. This causes the blood vessels to relax, which lowers blood pressure and reduces the force the heart needs to pump blood. It also slows down electrical activity in the heart, which is helpful for people with arrhythmias. Verapamil may also affect other calcium channels, potassium channels, and adrenergic receptors to help treat cluster
When to interrupt dosage
The recommended dose of Verelan Pm is contingent upon the diagnosed affliction, including Tachycardia, Ventricular, Unstable Angina Pectoris and Vasospastic Angina. The amount of dosage depends on the method of delivery as depicted in the table below.
Condition
Dosage
Administration
Angina, Stable
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous
Vasospastic Angina
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous
Heart Rate
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous
prophylaxis of Cluster headaches
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous
Angina, Unstable
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous
Cluster Headache
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous
Hypertensive disease
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous
Tachycardia, Ventricular
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous
Tachycardia, Supraventricular
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous
Atrial Fibrillation or Flutter
180.0 mg, 240.0 mg, , 120.0 mg, 360.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 80.0 mg, 2.4 mg, 2.5 mg/mL, 40.0 mg, 160.0 mg, 5.0 mg/mL, 10.0 mg/mL
Oral, , Tablet, extended release, Tablet, extended release - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Injection, Liquid, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous
Warnings
Verelan Pm has eleven contraindications and should not be utilized in tandem with the conditions given in the following table.
Verelan Pm Contraindications
Condition
Risk Level
Notes
Atrioventricular Block
Do Not Combine
Ventricular Tachycardia
Do Not Combine
Atrial Fibrillation
Do Not Combine
Shock, Cardiogenic
Do Not Combine
accessory bypass tract
Do Not Combine
Heart Failure
Do Not Combine
Pulse Frequency
Do Not Combine
Sick Sinus Syndrome
Do Not Combine
Bradycardia
Do Not Combine
Hypotension
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Verapamil may interact with Pulse Frequency
There are 20 known major drug interactions with Verelan Pm.
Common Verelan Pm Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Verapamil.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Verapamil.
Acepromazine
Major
Verapamil may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Verapamil.
Alfuzosin
Major
Verapamil may increase the hypotensive activities of Alfuzosin.
Verelan Pm Toxicity & Overdose Risk
The lowest toxic dose of verapamil in women is 14.4mg/kg and in men is 3.429mg/kg. The toxic dose in rats is 150mg/kg and in mice is 163mg/kg. If someone has overdosed on verapamil, treatment is generally supportive. Symptoms of overdose may include low blood pressure, slow heart rate, irregular heartbeat or non-cardiogenic pulmonary edema. In acute cases, doctors may use gastrointestinal decontamination with cathartics or bowel irrigation. Patients with severe heart depression may require intravenous calcium, atropine, or other treatments. If
Verelan Pm Novel Uses: Which Conditions Have a Clinical Trial Featuring Verelan Pm?
34 active clinical trials are assessing the capability of Verelan PM in managing Chronic Stable Angina Pectoris, Tachycardia, Ventricular and Paroxysmal Supraventricular Tachycardia (PSVT).
Condition
Clinical Trials
Trial Phases
Cluster Headache
2 Actively Recruiting
Phase 1, Phase 2
Heart Rate
0 Actively Recruiting
Tachycardia, Supraventricular
2 Actively Recruiting
Phase 3, Phase 2
Angina, Unstable
2 Actively Recruiting
Not Applicable
prophylaxis of Cluster headaches
0 Actively Recruiting
Vasospastic Angina
1 Actively Recruiting
Phase 2, Phase 3
Angina, Stable
0 Actively Recruiting
Atrial Fibrillation or Flutter
0 Actively Recruiting
Tachycardia, Ventricular
0 Actively Recruiting
Hypertensive disease
27 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Verelan Pm Reviews: What are patients saying about Verelan Pm?
5
Patient Review
10/6/2007
Verelan Pm for High Blood Pressure
5
Patient Review
4/5/2011
Verelan Pm for High Blood Pressure
5
Patient Review
6/11/2009
Verelan Pm for High Blood Pressure
5
Patient Review
10/23/2007
Verelan Pm for High Blood Pressure
5
Patient Review
11/24/2008
Verelan Pm for Migraine Prevention
5
Patient Review
9/20/2009
Verelan Pm for Prevention of Paroxysmal Supraventricular Tachycardia
2
Patient Review
5/8/2009
Verelan Pm for Migraine Prevention
Patient Q&A Section about verelan pm
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is verelan used to treat?
"Verapamil is a drug used to lower high blood pressure in order to prevent strokes, heart attacks, and kidney problems. Verapamil works by relaxing blood vessels so that blood can flow more easily and belongs to a class of drugs known as calcium channel blockers."
Answered by AI
Is verelan a calcium channel blocker?
"Verelan's active ingredient is a calcium channel blocker, which lowers blood pressure by reducing the force of the heart's contractions and relaxing the arteries."
Answered by AI
What form is verelan?
"The drug Verelan is used to treat irregular heart rhythms and belongs to a class of drugs known as antidysrhythmics, calcium channel blockers, and non-dihydropyridine calcium channel blockers."
Answered by AI
Can I take verapamil at night?
"You should take verapamil at around the same time(s) every day. Some verapamil products should be taken in the morning, and others should be taken at bedtime."
Answered by AI