Ibutilide Fumarate

Atrial Fibrillation
Treatment
3 FDA approvals
20 Active Studies for Ibutilide Fumarate

What is Ibutilide Fumarate

IbutilideThe Generic name of this drug
Treatment SummaryIbutilide is an intravenous medication used to treat abnormal heart rhythms, such as atrial flutter and atrial fibrillation. It works by restoring the normal rhythm of the heart, known as normal sinus rhythm (NSR).
Corvertis the brand name
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Ibutilide Fumarate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Corvert
Ibutilide
1995
4

Approved as Treatment by the FDA

Ibutilide, also known as Corvert, is approved by the FDA for 3 uses which include Atrial Fibrillation and Atrial Flutter .
Atrial Fibrillation
Helps manage Atrial Fibrillation
Atrial Flutter
Helps manage Atrial Flutter
Atrial Fibrillation
Helps manage Atrial Fibrillation

Effectiveness

How Ibutilide Fumarate Affects PatientsIbutilide affects the electrical activity of the heart, lengthening the time it takes for it to beat and making it harder for abnormal heart rhythms to start. It does this by activating a slow inward current (mostly sodium) at very low amounts, instead of blocking outward potassium currents which is the way most other heart rhythm drugs work.
How Ibutilide Fumarate works in the bodyIbutilide is an intravenous drug that helps treat heart rhythm problems. It works by changing the activity of certain types of potassium and calcium channels in your cells. Specifically, Ibutilide binds to and alters hERG, delayed inward rectifier potassium, and L-type calcium channels.

When to interrupt dosage

The amount of Ibutilide Fumarate is contingent upon the diagnosed condition. The dosage varies, as per the technique of delivery (e.g. Solution or Solution - Intravenous) noted in the table below.
Condition
Dosage
Administration
Atrial Fibrillation
, 0.1 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution, Solution - Intravenous

Warnings

There are 20 known major drug interactions with Ibutilide Fumarate.
Common Ibutilide Fumarate Drug Interactions
Drug Name
Risk Level
Description
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Asenapine.
Astemizole
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Astemizole.
Cisapride
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Cisapride.
Ibutilide Fumarate Toxicity & Overdose RiskAnimals who overdose on this drug may experience depression of the central nervous system, rapid breathing, and seizures. The lethal dose for rats is higher than 50mg/kg, which is at least 250 times the maximum recommended human dosage.
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Ibutilide Fumarate Novel Uses: Which Conditions Have a Clinical Trial Featuring Ibutilide Fumarate?

159 active studies are assessing the potential of Ibutilide Fumarate to ameliorate Atrial Fibrillation.
Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
96 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1

Patient Q&A Section about ibutilide fumarate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is ibutilide used for?

"Ibutilide is a medication used to treat atrial flutter and atrial fibrillation by converting them to normal sinus rhythm. It can also be used as a pretreatment for electro cardioversion, though this is not an officially approved use."

Answered by AI

What class of drug is ibutilide?

"Ibutilide is an antiarrhythmic drug that is only available for intravenous use. It is used to terminate atrial arrhythmias."

Answered by AI

What does ibutilide do to the heart?

"Ibutilide belongs to a class of antiarrhythmic drugs called class III agents. Ibutilide enhances the slow inward sodium current, while other class III agents work by blocking cardiac potassium channels. Ibutilide can be used as a one-time intravenous infusion to cardiovert atrial fibrillation or atrial flutter to sinus rhythm chemically."

Answered by AI

How is ibutilide administered?

"The recommended dose of ibutilide for intravenous administration in patients weighing ≥60 kg is 1 mg over a 10-minute period. If the arrhythmia has not terminated, a second 10-minute infusion of equal strength can be given 10 minutes after the end of the initial infusion."

Answered by AI

Clinical Trials for Ibutilide Fumarate

Have you considered Ibutilide Fumarate clinical trials? We made a collection of clinical trials featuring Ibutilide Fumarate, we think they might fit your search criteria.
Have you considered Ibutilide Fumarate clinical trials? We made a collection of clinical trials featuring Ibutilide Fumarate, we think they might fit your search criteria.
Have you considered Ibutilide Fumarate clinical trials? We made a collection of clinical trials featuring Ibutilide Fumarate, we think they might fit your search criteria.
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