Ibutilide Fumarate

Atrial Fibrillation
Treatment
3 FDA approvals
20 Active Studies for Ibutilide Fumarate

What is Ibutilide Fumarate

IbutilideThe Generic name of this drug
Treatment SummaryIbutilide is an intravenous medication used to treat abnormal heart rhythms, such as atrial flutter and atrial fibrillation. It works by restoring the normal rhythm of the heart, known as normal sinus rhythm (NSR).
Corvertis the brand name
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Ibutilide Fumarate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Corvert
Ibutilide
1995
4

Approved as Treatment by the FDA

Ibutilide, also known as Corvert, is approved by the FDA for 3 uses which include Atrial Fibrillation and Atrial Fibrillation .
Atrial Fibrillation
Helps manage Atrial Fibrillation
Atrial Fibrillation
Helps manage Atrial Fibrillation
Atrial Flutter
Helps manage Atrial Flutter

Effectiveness

How Ibutilide Fumarate Affects PatientsIbutilide affects the electrical activity of the heart, lengthening the time it takes for it to beat and making it harder for abnormal heart rhythms to start. It does this by activating a slow inward current (mostly sodium) at very low amounts, instead of blocking outward potassium currents which is the way most other heart rhythm drugs work.
How Ibutilide Fumarate works in the bodyIbutilide is an intravenous drug that helps treat heart rhythm problems. It works by changing the activity of certain types of potassium and calcium channels in your cells. Specifically, Ibutilide binds to and alters hERG, delayed inward rectifier potassium, and L-type calcium channels.

When to interrupt dosage

The amount of Ibutilide Fumarate is contingent upon the diagnosed condition. The dosage varies, as per the technique of delivery (e.g. Solution or Solution - Intravenous) noted in the table below.
Condition
Dosage
Administration
Atrial Fibrillation
, 0.1 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Solution - Intravenous, Solution

Warnings

There are 20 known major drug interactions with Ibutilide Fumarate.
Common Ibutilide Fumarate Drug Interactions
Drug Name
Risk Level
Description
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Asenapine.
Astemizole
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Astemizole.
Cisapride
Major
The risk or severity of QTc prolongation can be increased when Ibutilide is combined with Cisapride.
Ibutilide Fumarate Toxicity & Overdose RiskAnimals who overdose on this drug may experience depression of the central nervous system, rapid breathing, and seizures. The lethal dose for rats is higher than 50mg/kg, which is at least 250 times the maximum recommended human dosage.
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Ibutilide Fumarate Novel Uses: Which Conditions Have a Clinical Trial Featuring Ibutilide Fumarate?

159 active studies are assessing the potential of Ibutilide Fumarate to ameliorate Atrial Fibrillation.
Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
95 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1

Patient Q&A Section about ibutilide fumarate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is ibutilide used for?

"Ibutilide is a medication used to treat atrial flutter and atrial fibrillation by converting them to normal sinus rhythm. It can also be used as a pretreatment for electro cardioversion, though this is not an officially approved use."

Answered by AI

What class of drug is ibutilide?

"Ibutilide is an antiarrhythmic drug that is only available for intravenous use. It is used to terminate atrial arrhythmias."

Answered by AI

What does ibutilide do to the heart?

"Ibutilide belongs to a class of antiarrhythmic drugs called class III agents. Ibutilide enhances the slow inward sodium current, while other class III agents work by blocking cardiac potassium channels. Ibutilide can be used as a one-time intravenous infusion to cardiovert atrial fibrillation or atrial flutter to sinus rhythm chemically."

Answered by AI

How is ibutilide administered?

"The recommended dose of ibutilide for intravenous administration in patients weighing ≥60 kg is 1 mg over a 10-minute period. If the arrhythmia has not terminated, a second 10-minute infusion of equal strength can be given 10 minutes after the end of the initial infusion."

Answered by AI

Clinical Trials for Ibutilide Fumarate

Image of Inova Alexandria Hospital in Alexandria, United States.

Heparin Dosing for Blood Clots and Heart Conditions

18+
All Sexes
Alexandria, VA
The goal of this clinical trial study is to test whether a mathematical calculation, using the patient's gender, weight and kidney function, can better predict a patient's heparin goal dose than a flat number of units per patient weight can. Participants will have the first dose of heparin infusion calculated, after which if adjustments are needed, the Hospital's prebuilt table for results driven dosing for this purpose is used. The researchers will compare the time it takes for the participants to get to the desired goal using the patient's information for calculation versus patients in the past who received the medication using the flat rate. The hypothesis is that the patients with enhanced personal data, gender, weight and kidney function, included for the initial dose, will get to their goal lab value sooner and with less chance of delay or overshooting the goal. A quicker time to goal lab value is beneficial to patients in many ways, including earlier treatment of the clot or coronary issue that the patient is experiencing.
Phase 4
Waitlist Available
Inova Alexandria Hospital
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Image of Mission Cardiovascular Research Institute in Fremont, United States.

REGN7508 + REGN9933 for Atrial Fibrillation

18+
All Sexes
Fremont, CA
This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly. REGN7508 and REGN9933 are designed to help stop blood clots forming in patients with atrial fibrillation. The aim of the study is to see how well REGN7508 and REGN9933 work in patients that get medicine for their atrial fibrillation. The bleeding effects of REGN7508 and REGN9933 will be compared to another medicine (apixaban), which is available on the market to treat and prevent formation of blood clots. The study is looking at several other research questions, including: * What side effects may happen from taking REGN7508 or REGN9933 * How well do the study drugs reduce the risk of having a stroke * How much of REGN7508 or REGN9933 is in the blood at different times * Whether the body makes antibodies against REGN7508 or REGN9933 (which could make the drugs less effective or could lead to side effects)
Phase 2
Recruiting
Mission Cardiovascular Research Institute (+4 Sites)Clinical Trial ManagementRegeneron Pharmaceuticals
Have you considered Ibutilide Fumarate clinical trials? We made a collection of clinical trials featuring Ibutilide Fumarate, we think they might fit your search criteria.Go to Trials
Image of The Ottawa Hospital Civic Campus in Ottawa, Canada.

Cardiac CT Angiography for Atrial Fibrillation and Flutter

18+
All Sexes
Ottawa, Canada
The goal of this randomized clinical trial is to learn whether patients with symptomatic atrial fibrillation or atrial flutter (AF) who require heart imaging to rule out a blood clot before cardioversion would benefit from cardiac computed tomography angiography (CCT) in the emergency department (ED) compared to current standard of care management. This will be a multicenter trial evaluating whether CCT-facilitated cardioversion in the ED reduces hospital admission, reduces repeat presentations to hospital and improves patient quality of life compared to the current standard of care. Participants will undergo CCT-facilitated cardioversion or be treated according to current standard of care while in the ED and complete quality of life questionnaires in the ED and follow-up at 30 days.
Waitlist Available
Has No Placebo
The Ottawa Hospital Civic CampusBenjamin Chow, MD PhD FRCPC FACC FESC FA
Image of UCSF Medical Center at Parnassus in San Francisco, United States.

Alcohol Abstinence for Atrial Fibrillation

18+
All Sexes
San Francisco, CA
Per the 2021 National Survey on Drug Use and Health administered by the U.S. Department of Health and Human Services, 85% of all American adults consume alcohol. Atrial fibrillation (AF) is the most common arrhythmia, affecting more than 10 million individuals in U.S., comprising 4.5% of the adult population. Although alcohol abstinence clearly reduces AF in heavy drinkers, observational data comparing the health effects of limited consumption versus abstention are conflicting. The Mediterranean diet is one of the few that has demonstrated clear cardiovascular benefits in a randomized study-this diet allows for the consumption of red wine (or high polyphenol/ low alcohol alcohol), generally not more than one drink in 24 hours, with meals, avoiding spirits and binge drinking. The effect of the "Mediterranean drinking pattern" on AF risk compared to alcohol abstinence remains unknown. This single center, randomized, controlled trial aims to compare the effects of a digital health intervention to encourage durable alcohol abstinence versus allowing guideline-adherent moderate alcohol consumption on AF severity. The knowledge gained from this study may be used to determine optimal thresholds for alcohol use among AF patients.
Recruiting
Has No Placebo
UCSF Medical Center at ParnassusGregory M Marcus, MD, MAS
Have you considered Ibutilide Fumarate clinical trials? We made a collection of clinical trials featuring Ibutilide Fumarate, we think they might fit your search criteria.Go to Trials
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