Ketotifen Fumarate
Eye, Seasonal Allergic Conjunctivitis, Asthma, Allergic + 1 more
Treatment
4 Active Studies for Ketotifen Fumarate
Treatment for
Eye
What is Ketotifen Fumarate
Ketotifen
The Generic name of this drug
Treatment Summary
Ketotifen is a medication used to treat allergies. It works by blocking the action of histamines, which are responsible for triggering allergic reactions. It was first developed in 1970 and is now available in an over-the-counter version for itchy eyes in the US, and a prescription-only version in Canada for children with asthma. In addition, ketotifen is used around the world to treat symptoms of allergies such as hives, mastocytosis, and food allergies.
Allergy Eye Original Prescription Strength
is the brand name
Ketotifen Fumarate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Allergy Eye Original Prescription Strength
Ketotifen
1995
104
Effectiveness
How Ketotifen Fumarate Affects Patients
Ketotifen is a medication that stops the body from responding to substances that cause inflammation, such as histamine. It is mainly used to treat asthma, and can take up to two months to produce results. However, it has been shown to reduce the frequency, severity, and duration of asthma symptoms, which may allow for a decrease in the need for other asthma medications.
How Ketotifen Fumarate works in the body
Ketotifen works by blocking the action of histamine, which is released during allergic reactions. It also prevents cells from releasing other substances that can cause inflammation. In addition, it helps to stop airway hyperreactivity, eosinophil accumulation in the airways, and bronchoconstriction due to leukotrienes.
When to interrupt dosage
Condition
Dosage
Administration
Eye
, 0.35 mg/mL, 0.25 mg/mL, 0.345 mg/mL, 250.0 mg/mL, 1.0 mg, 0.5 mg/mL, 1.0 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Oral, Tablet - Oral, Syrup - Oral, Syrup, Solution / drops - Oral, Tablet
Seasonal Allergic Conjunctivitis
, 0.35 mg/mL, 0.25 mg/mL, 0.345 mg/mL, 250.0 mg/mL, 1.0 mg, 0.5 mg/mL, 1.0 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Oral, Tablet - Oral, Syrup - Oral, Syrup, Solution / drops - Oral, Tablet
Asthma, Allergic
, 0.35 mg/mL, 0.25 mg/mL, 0.345 mg/mL, 250.0 mg/mL, 1.0 mg, 0.5 mg/mL, 1.0 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Oral, Tablet - Oral, Syrup - Oral, Syrup, Solution / drops - Oral, Tablet
Allergic Conjunctivitis (AC)
, 0.35 mg/mL, 0.25 mg/mL, 0.345 mg/mL, 250.0 mg/mL, 1.0 mg, 0.5 mg/mL, 1.0 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Oral, Tablet - Oral, Syrup - Oral, Syrup, Solution / drops - Oral, Tablet
Warnings
Ketotifen Fumarate Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ketotifen may interact with Pulse Frequency
There are 13 known major drug interactions with Ketotifen Fumarate.
Common Ketotifen Fumarate Drug Interactions
Drug Name
Risk Level
Description
Pitolisant
Major
The therapeutic efficacy of Pitolisant can be decreased when used in combination with Ketotifen.
Benzylpenicilloyl polylysine
Moderate
Ketotifen may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent.
Betahistine
Moderate
The therapeutic efficacy of Betahistine can be decreased when used in combination with Ketotifen.
Deoxyepinephrine
Moderate
The therapeutic efficacy of Deoxyepinephrine can be increased when used in combination with Ketotifen.
Droxidopa
Moderate
The therapeutic efficacy of Droxidopa can be increased when used in combination with Ketotifen.
Ketotifen Fumarate Toxicity & Overdose Risk
Taking more than the recommended dose of ketotifen has been reported, but no deaths have been reported. Signs of an overdose may include drowsiness, confusion, rapid heart rate, low blood pressure, seizures, agitation (especially in children), and/or temporary loss of consciousness. If taken recently, doctors may suggest using a stomach pump or activated charcoal to reduce the effects. Other treatments can be given depending on the symptoms. Medications like physostigmine might be used to lessen anticholinergic effects, and drugs like barbiturates or benzodiazepines can be used if the patient is overly excited or having
Ketotifen Fumarate Novel Uses: Which Conditions Have a Clinical Trial Featuring Ketotifen Fumarate?
14 active studies are being conducted to assess Ketotifen Fumarate's potential for alleviating symptoms of Seasonal Allergic Conjunctivitis, Hay Fever and Allergic Asthma.
Condition
Clinical Trials
Trial Phases
Seasonal Allergic Conjunctivitis
0 Actively Recruiting
Allergic Conjunctivitis (AC)
1 Actively Recruiting
Phase 2
Eye
0 Actively Recruiting
Asthma, Allergic
3 Actively Recruiting
Early Phase 1, Phase 3, Phase 2
Patient Q&A Section about ketotifen fumarate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is ketotifen fumarate used for?
"Ketotifen is a daily asthma medication that can help reduce the frequency, severity, and duration of asthma symptoms or attacks in children. It may also lead to a reduction in daily requirements of other asthma medications."
Answered by AI
Is ketotifen fumarate safe?
"Additionally, in over 10 years on the market, there have been no reported adverse effects associated with Zaditor.
Is Zaditor (ketotifen fumarate) safe? According to the FDA, Zaditor (ketotifen fumarate) is safe for OTC use based on the long-term use of the drug as well as the controlled clinical studies that originally supported the prescription-strength formula. Additionally, there have been no reported adverse effects associated with Zaditor in the over 10 years it has been on the market."
Answered by AI
Is ketotifen fumarate an antihistamine?
"Ketotifen is a medication used to relieve the itching of allergic conjunctivitis, also known as pink eye. Ketotifen belongs to a class of medications called antihistamines. It works by blocking histamine, a substance in the body that causes allergic symptoms."
Answered by AI
Is ketotifen a steroid?
"Ketotifen is an antiallergic drug that is used as a prophylactic medicine. Some trials have suggested that ketotifen has similar efficacy to cromoglicate in asthma and also a small steroid-sparing effect. It is more effective than placebo in the treatment of atopic dermatitis."
Answered by AI